Impact of low phosphate levels on weaning off mechanical ventilation
Hypophosphatemia in Wean
This study is testing if giving a phosphate supplement can help patients with low phosphate levels breathe better and get off mechanical ventilation more easily.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Peking Union Medical College Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT06754670 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between hypophosphatemia and the efficiency of weaning patients off mechanical ventilation. It aims to understand how low phosphate levels may affect neural conduction and muscle contraction, particularly in the diaphragm, which is crucial for respiratory function. The study will evaluate patients who have been on invasive ventilation for at least 48 hours and are transitioning to auxiliary ventilation. By administering sodium glycerophosphate, the researchers hope to determine if correcting hypophosphatemia can enhance respiratory muscle strength and facilitate successful weaning.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are experiencing acute respiratory failure and have been on invasive ventilation for at least 48 hours.
Not a fit: Patients with severe neuromuscular diseases or central nervous system disorders are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved weaning protocols for patients on mechanical ventilation, potentially reducing the duration of ventilation and associated complications.
How similar studies have performed: While previous studies have indicated a link between hypophosphatemia and prolonged mechanical ventilation, this specific approach to correcting phosphate levels in the context of weaning has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: age ≥18 years old; Acute respiratory failure, tracheal intubation patients; Invasive ventilator use time ≥48 hours; Clinically determined remission of primary disease, has switched to auxiliary ventilation mode and plans to go offline in the near future. Exclusion criteria: patients with severe neuromuscular disease; Patients with central system diseases; Patients using muscle relaxants for more than 48 hours; Patients who have been or are about to be discontinued from life support; Patients with contraindications for gastric tube insertion after esophagogastric fundus varices, digestive tract perforation, and upper digestive tract surgery; Pregnant patients; Ultrasonic window is poor.
Where this trial is running
Beijing
- Peking Union Medical College Hospital — Beijing, China (Recruiting)
Study contacts
- Study coordinator: Shitong Diao, MD
- Email: diaost@foxmail.com
- Phone: 86-13833117878
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.