Impact of low phosphate levels on weaning off mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between hypophosphatemia and the efficiency of weaning patients off mechanical ventilation. It aims to understand how low phosphate levels may affect neural conduction and muscle contraction, particularly in the diaphragm, which is crucial for respiratory function. The study will evaluate patients who have been on invasive ventilation for at least 48 hours and are transitioning to auxiliary ventilation. By administering sodium glycerophosphate, the researchers hope to determine if correcting hypophosphatemia can enhance respiratory muscle strength and facilitate successful weaning.

Why it matters

Who can join: the full rules

Inclusion criteria:

age ≥18 years old; Acute respiratory failure, tracheal intubation patients; Invasive ventilator use time ≥48 hours; Clinically determined remission of primary disease, has switched to auxiliary ventilation mode and plans to go offline in the near future.

Exclusion criteria:

patients with severe neuromuscular disease; Patients with central system diseases; Patients using muscle relaxants for more than 48 hours; Patients who have been or are about to be discontinued from life support; Patients with contraindications for gastric tube insertion after esophagogastric fundus varices, digestive tract perforation, and upper digestive tract surgery; Pregnant patients; Ultrasonic window is poor.

Where it's running

• Peking Union Medical College Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Shitong Diao, MD
• Email: diaost@foxmail.com
• Phone: 86-13833117878

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.