Advancing Acute Respiratory Infection Care for Kids on Home Ventilators
Official title: Advancing Acute Respiratory Infection Treatment in Pediatric Invasive Home Mechanical Ventilation
Funded at Lurie Children's Hospital of Chicago · NIH-11446490 · Data updated 2026-11-12
This grant aims to improve how doctors and families manage acute respiratory infections in children who rely on invasive long-term home ventilation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $876,614 |
| NIH project number | 1R01HL183395-01A1 |
| Project ID | NIH-11446490 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children using invasive long-term home mechanical ventilation who experience acute respiratory infections.
✕Less likely to help
Children without invasive home ventilation or those not experiencing acute respiratory infections may not benefit from this specific research.
What this research studies
Parents and clinicians care for children who depend on home ventilators, and this project seeks to understand which factors influence when to treat at home, in the ED, or in the hospital during respiratory infections. By studying real-world patterns and responses to care, the team hopes to standardize decision-making and improve safety for these high-risk kids. The research would use home monitoring data and clinical records to identify modifiable factors that affect outcomes, with the goal of guiding better treatment choices. The work is led by Carolyn C. Foster at Lurie Children’s Hospital of Chicago and will occur over several years at a pediatric care center.
Why it matters
Potential benefit: If successful, the project could reduce hospitalizations and improve survival and quality of life for children on home mechanical ventilation during respiratory infections.
How similar studies have gone: Previous work in other respiratory or cardiac conditions suggests that home monitoring and standardized care can improve outcomes, but there is little empirical evidence in pediatric LTMV patients.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Foster, Carolyn C. — Lurie Children's Hospital of Chicago
- Study coordinator: Foster, Carolyn C.
Related research
Other NIH-funded projects on the same topics.
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A Tablet-Based Emotion Regulation Program for Surrogate Decision-Makers of ICU Patients on Ventilation
A randomized trial tests a brief tablet program to help people who decide for ICU patients on ventilation feel less anxious and make better decisions.
-
Optimizing pain relief for children on mechanical ventilation
A large, multi-site trial tests whether adding non-opioid pain medicines to standard opioid care can reduce pain and lower opioid use in children on breathing machines in PICUs.
-
Role of titin in diaphragm weakness during mechanical ventilation
This grant studies how the diaphragm’s core proteins work together, especially titin and myosin, to understand why diaphragm weakness happens during mechanical ventilation.
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Time-limited trials to guide invasive ventilation decisions
A scientific team is testing how short, structured trials of life-support in ICU patients with acute respiratory failure can help patients and families choose the best path.
-
How breathing machines can harm the kidneys
Doctors will look at how ventilators change kidney filtering and salt handling in people who are critically ill to help prevent kidney damage.
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Optimizing Time-Limited Trials of Ventilation in Acute Respiration Failure
Aimed at patients with acute respiratory failure, this project looks at how short-term trials of life-support in the ICU can be better planned and communicated.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.