Inspiratory Effort and Dyspnea During Assisted Mechanical Ventilation in Critically Ill Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this observational study, researchers explore how a patient’s inspiratory effort interacts with ventilator support during assisted mechanical ventilation. They aim to identify acceptable ranges of effort and how measurements like P0.1, Pes, and PTP relate to dyspnea and weaning outcomes. The study focuses on adults in the ICU who require prolonged or difficult weaning and are on pressure-support or similar assisted modes. Measurement of respiratory effort will be done with esophageal balloon catheters and standard ventilator outputs, while dyspnea assessments capture patient experience. The goal is to improve individualized pressure-support titration to balance prevention of fatigue with avoidance of over-assistance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient admitted to the ICU.
* Receiving invasive assisted mechanical ventilation in a pressure-support mode or another assisted mode permitting measurement of the prespecified variables.
* Prolonged or difficult weaning.
* Receiving pressure support of at least 5 cmH2O at screening.
* Written informed consent from the participant or legally authorized representative, in accordance with local ethics requirements.
* Ability to undergo the planned physiological monitoring and dyspnea assessment.

Exclusion Criteria:

* Contraindication to nasogastric placement or to placement/use of an esophageal-gastric balloon catheter for Pes and Pgas measurement.
* Refusal of consent by the participant or legally authorized representative.
* Any clinical condition in which the treating physician considers study measurements or pressure-support titration unsafe (unstable hemodynamics, uncontrolled arrhythmia, severe hypoxemia, active myocardial ischemia etc.)

Where it's running

• University Hospital of Heraklion
  Heraklion, Greece Recruiting

Study contacts

• Study coordinator: Katerina Vaporidi, MD, PhD
• Email: vaporidi@uoc.gr
• Phone: +30 2810 392718 / 2810 394729

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Measuring breathing drive and effort at different pressure support levels after major abdominal surgery

  This project will test whether changing pressure support levels can reveal under- or over-assistance of breathing in adults on ventilators after major abdominal surgery.

  Recruiting Mahidol University · Bangkok, Bangkoknoi · NCT07199881

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation

  This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.

  Recruiting Capital Medical University · Beijing · NCT07886918

• Noninvasive estimate of inspiratory effort to monitor pressure support ventilation

  This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.

  Recruiting Capital Medical University · Beijing · NCT07886892

• Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery

  In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.

  Recruiting Hopital Charles Nicolle · Tunis · NCT07885124

• FCV vs VC—Obese Adults Undergoing Laparoscopic Surgery

  In obese adults having laparoscopic surgery, researchers will see if flow-controlled ventilation (FCV) works better than volume-controlled ventilation with autoflow (VC-AF) at keeping airway pressures and lung energy lower.

  Recruiting Kocaeli University · Kocaeli, Izmit · NCT07875530

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.