How different ventilator settings affect lung energy during gallbladder surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In adults scheduled for elective laparoscopic cholecystectomy, researchers compare two ventilation modes—volume-controlled ventilation (VCV) and pressure-regulated volume control (PRVC)—to see how much mechanical power is delivered to the lungs. The comparison is done in a randomized, cross-over design during the same surgery to assess energy transfer despite differences in peak airway pressure. Mechanical power, a surrogate for potential lung stress, is calculated from ventilator data to determine if PRVC’s lower peak pressure translates to lower overall lung energy. The trial is observationally focused on ventilation parameters and does not involve experimental drugs or therapies. Results could inform safer ventilation strategies for patients without significant lung disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing elective laparoscopic cholecystectomy surgery.
* Patients between 18 and 75 years of age.
* American Society of Anesthesiologists (ASA) physical status I, II or III.
* Body Mass Index (BMI) between 18.5 and 35 kg/m².
* Voluntary written informed consent for participation.

Exclusion Criteria:

* History of significant chronic obstructive pulmonary disease (COPD) or asthma.
* Previous lung resection or major thoracic surgery.
* Heavy smokers (more than 20 cigarettes per day).
* Presence of spontaneous breathing effort during mechanical ventilation.
* Conversion from laparoscopic surgery to open surgery during the procedure.
* Emergency surgery cases.
* Known pregnancy.

Where it's running

• Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital
  Yenimahalle, Ankara, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: arif timuroglu, MD
• Email: ariftimuroglu@yahoo.com
• Phone: +905072601980

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.