Personalized diaphragm pacing to improve outcomes in ventilated patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of personalized external diaphragm pacing (EDP) guided by real-time diaphragm ultrasound in improving outcomes for patients on invasive mechanical ventilation. By assessing diaphragm function and adjusting pacing parameters for each patient, the study aims to prevent diaphragm muscle weakening and enhance the chances of successful weaning from the ventilator. Key metrics such as diaphragm thickening fraction and rapid shallow breathing index will be utilized to optimize treatment. The trial will compare personalized EDP with standard weaning protocols in critically ill patients requiring long-term respiratory support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults ≥18 years of age undergoing invasive mechanical ventilation.
2. Expected duration of mechanical ventilation ≥48 hours.

Exclusion Criteria:

1. ICU expected length of stay less than 48 hours
2. severe phrenic nerve or diaphragmatic injury that is unable to respond to diaphragmatic pacing.
3. Patients who have received or are scheduled to receive other respiratory assistance or diaphragmatic pacing interventions.
4. Patients with end-stage disease with an expected survival of \<6 months.
5. Patients who are unable to be weaned from mechanical ventilation, such as patients with severe brain injury or paraplegia.

Where it's running

• Affiliated Hospital of Nantong University
  Nantong, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Daishan Jiang
• Email: jiangdaishan@ntu.edu.cn
• Phone: +8613773627637

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.