Doxapram to improve diaphragm movement during spontaneous breathing trials in ventilated COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center observational protocol in which intravenous doxapram is administered during spontaneous breathing trials in mechanically ventilated patients with moderate to severe COPD. Diaphragmatic excursion will be measured by an expert using respiratory muscle ultrasound before and after doxapram administration. Patients with doxapram allergy, neuromuscular disorders, or inability to visualize the diaphragm will be excluded. The study is conducted at Cairo University and collects physiologic ultrasound endpoints rather than clinical outcomes like weaning success.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with moderate to severe chronic obstructive pulmonary disease undergoing spontaneous breathing trial

Exclusion Criteria:

* Refusal Allergy to doxapram neuromuscular disorders inability to evaluate the diaphragm

Where it's running

• Cairo University
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Mina Helmy, MD
• Email: dr_mina20002010@yahoo.com
• Phone: +201007174836

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.