Investigating neuromuscular blockers in mechanically ventilated patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to evaluate the effects of different neuromuscular blockers on patients who are mechanically ventilated in emergency departments. It will involve screening and enrolling eligible patients across five medical centers over three years, using a stepped wedge cluster randomized design. Initially, all sites will provide usual care, followed by a transition to using succinylcholine as the default neuromuscular blocker in a staggered manner. The study will assess the impact of these interventions on patient outcomes, particularly focusing on awareness and complications related to intubation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Mechanical ventilation via an endotracheal tube
2. Age ≥ 18 years
3. Treatment with a neuromuscular blocker (for endotracheal intubation or during the post-intubation phase of care)

Exclusion Criteria:

1. Acute or chronic neurologic injury with deficit that prevents assessment of AWP (i.e. stroke, intracranial hemorrhage, traumatic brain injury, cardiac arrest, severe dementia)
2. Death before extubation
3. Transfer to another hospital from the ED

Where it's running

• Roy J. and Lucille A. Carver College of Medicine
  Iowa City, Iowa, United States Recruiting
• Hennepin Healthcare
  Minneapolis, Minnesota, United States Recruiting
• Cooper University Hospital/Cooper Medical School of Rowan University
  Camden, New Jersey, United States Recruiting
• University of Washington School of Medicine
  Seattle, Washington, United States Recruiting

Study contacts

• Principal investigator: Brian Fuller, MD — Washington University School of Medicine
• Study coordinator: Brian Fuller, MD
• Email: fullerb@wustl.edu
• Phone: 314-747*5368

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.