Right heart function after cardiac surgery: does respiratory acidosis matter?
Official title: Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery
Run by Laval University · NCT07619274 · Data updated 2026-11-12
This study looks at whether respiratory acidosis after heart surgery affects how well the right side of the heart works in ICU patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | Laval University Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Status | Recruiting |
| Started | July 20, 2026 |
| Main results expected | December 2026 |
| Study ends | June 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07619274 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Patients who were previously enrolled in and completed either NCT05886413 or NCT06826794 and have complete hemodynamic data and an arterial blood gas on ICU arrival.
✕Probably not a fit
Patients lacking the required hemodynamic measurements or arterial blood gas data on ICU arrival may not benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational analysis uses post hoc data from two previously approved studies to examine the association between early respiratory acidosis and right ventricular function after cardiac surgery. It stratifies patients by pH < 7.35 and PaCO2 > 45 mmHg on the first arterial blood gas in the ICU. Key hemodynamic measurements are required, including mean pulmonary pressures, central venous pressure, and cardiac output. No interventions are performed; the study observes existing data to identify potential links between acidosis and right heart performance.
Why it matters
Potential benefit: If associations are found, clinicians may better identify patients at risk for right heart dysfunction after surgery and tailor monitoring or management accordingly.
How similar studies have gone: There is precedent for post hoc analyses using existing datasets to explore cardio-pulmonary interactions after surgery, though the specific link with respiratory acidosis and RV function has limited prior direct evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Previously included and complete study NCT05886413 or NCT06826794 Exclusion Criteria: * Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output * Absence of arterial blood gas on arrival to the intensive care unit
Where it's running
-
Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval
Québec, Quebec, Canada Recruiting
Study contacts
- Study coordinator: Etienne Couture
- Email: etienne.couture.3@ulaval.ca
- Phone: 1-418-656-8711
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.