Respiratory acidosis during one-lung ventilation and how clinician settings compare with the VentilO app
Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application
This project will try to see if ventilator settings chosen by clinicians or settings suggested by the VentilO smartphone app better prevent respiratory acidosis in adults having one-lung ventilation for thoracic surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Laval University Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Trial ID | NCT07099963 on ClinicalTrials.gov |
What this trial studies
This retrospective pilot uses intraoperative records from adults who had one-lung, volume-controlled ventilation during thoracic surgery to measure how often and how severe respiratory acidosis occurred with initial ventilator settings. It compares the tidal volume and respiratory rate chosen by clinicians to the settings proposed by the VentilO application and links those settings to arterial blood gas results. Patients without arterial blood gas data or missing key demographic information are excluded. The analysis aims to determine whether individualized settings suggested by the app would have reduced hypercapnia and acidosis compared with routine clinician choices.
Who should consider this trial
Good fit: Adults (≥18 years) intubated for thoracic surgery who received one-lung, volume-controlled ventilation and have arterial blood gas and basic demographic data available.
Not a fit: Patients who are not intubated, who receive two-lung ventilation, who lack arterial blood gas measurements or key demographic data, or who were managed with non–volume-controlled ventilation are not included and are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, the findings could help clinicians choose ventilator settings that reduce respiratory acidosis and lower the risk of postoperative respiratory complications.
How similar studies have performed: Protective low tidal volume strategies during one-lung ventilation have shown benefit in reducing lung injury, but using a smartphone app like VentilO to recommend individualized respiratory rates is relatively novel and not widely validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥ 18 years old) * Patients intubated and undergoing one-lung ventilation during thoracic surgery * Volume-controlled ventilation mode used intraoperatively Exclusion Criteria: * Arterial blood gas data unavailable during one-lung ventilation * Missing demographic data (sex, height, actual weight)
Where this trial is running
Québec, Quebec
- Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval — Québec, Quebec, Canada (Recruiting)
Study contacts
- Study coordinator: Francois Lellouche
- Email: francois.lellouche@criucpq.ulaval.ca
- Phone: 1-418-656-8711
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.