Respiratory acidosis during one-lung ventilation and how clinician settings compare with the VentilO app
Official title: Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application
Run by Laval University · NCT07099963 · Data updated 2026-11-12
This project will try to see if ventilator settings chosen by clinicians or settings suggested by the VentilO smartphone app better prevent respiratory acidosis in adults having one-lung ventilation for thoracic surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Laval University Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | March 1, 2026 |
| Study ends | June 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07099963 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) intubated for thoracic surgery who received one-lung, volume-controlled ventilation and have arterial blood gas and basic demographic data available.
✕Probably not a fit
Patients who are not intubated, who receive two-lung ventilation, who lack arterial blood gas measurements or key demographic data, or who were managed with non–volume-controlled ventilation are not included and are unlikely to benefit directly.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This retrospective pilot uses intraoperative records from adults who had one-lung, volume-controlled ventilation during thoracic surgery to measure how often and how severe respiratory acidosis occurred with initial ventilator settings. It compares the tidal volume and respiratory rate chosen by clinicians to the settings proposed by the VentilO application and links those settings to arterial blood gas results. Patients without arterial blood gas data or missing key demographic information are excluded. The analysis aims to determine whether individualized settings suggested by the app would have reduced hypercapnia and acidosis compared with routine clinician choices.
Why it matters
Potential benefit: If successful, the findings could help clinicians choose ventilator settings that reduce respiratory acidosis and lower the risk of postoperative respiratory complications.
How similar studies have gone: Protective low tidal volume strategies during one-lung ventilation have shown benefit in reducing lung injury, but using a smartphone app like VentilO to recommend individualized respiratory rates is relatively novel and not widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥ 18 years old) * Patients intubated and undergoing one-lung ventilation during thoracic surgery * Volume-controlled ventilation mode used intraoperatively Exclusion Criteria: * Arterial blood gas data unavailable during one-lung ventilation * Missing demographic data (sex, height, actual weight)
Where it's running
-
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec, Canada Recruiting
Study contacts
- Study coordinator: Francois Lellouche
- Email: francois.lellouche@criucpq.ulaval.ca
- Phone: 1-418-656-8711
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.