Flow-controlled versus volume-controlled ventilation during bariatric surgery
Official title: Comparison of Flow-Controlled and Volume-Controlled Ventilation During Bariatric Surgery: A Prospective Randomized Trial
Run by Ankara Etlik City Hospital · NCT07430111 · Data updated 2026-11-12
This trial will see if flow-controlled ventilation or volume-controlled ventilation gives better oxygen levels and lower airway pressures during bariatric surgery in adults with obesity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Ankara Etlik City Hospital Government |
| Locations | 1 site (Ankara) |
| Status | Recruiting |
| Started | February 24, 2026 |
| Main results expected | February 5, 2027 |
| Study ends | February 18, 2027 |
| Registry record updated | February 25, 2026 |
| Trial ID | NCT07430111 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 years old with BMI ≥30 kg/m², ASA physical status II–III, no significant preexisting pulmonary disease, and scheduled for bariatric surgery are ideal candidates.
✕Probably not a fit
Patients outside the age or ASA ranges, those with known significant pulmonary disease or severe preoperative respiratory impairment, and those requiring chronic supplemental oxygen are unlikely to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 18–65 with a BMI of 30 kg/m² or higher and ASA physical status II–III who are undergoing bariatric surgery will be assigned to receive either flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) during general anesthesia. Ventilatory parameters including peak and plateau airway pressures, pulmonary compliance, and arterial oxygen tension (PaO2) will be recorded at predefined intraoperative time points. The primary endpoint is PaO2 measured at the 20th minute while on an FiO2 of 0.8–1.0. The study compares intraoperative oxygenation and airway mechanics to identify whether one ventilation mode offers better physiologic outcomes in obese surgical patients.
Why it matters
Potential benefit: If successful, this could improve intraoperative oxygenation and reduce airway pressures during bariatric surgery, which may lower the risk of perioperative pulmonary complications.
How similar studies have gone: Physiological studies and small clinical series have suggested FCV can lower airway pressures and improve compliance versus conventional modes, but its benefit specifically in obese bariatric patients is not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 65 years * Body mass index (BMI) ≥ 30 kg/m² * ASA physical status II-III Exclusion Criteria: * ASA physical status I or IV and above * Known or previously diagnosed pulmonary disease * Patients with severe preoperative pulmonary function impairment (e.g., FEV₁ \< 50% predicted, severe restrictive or obstructive pathology) * Patients with markedly altered lung anatomy or function due to prior major thoracic surgery * Patients who were dependent on supplemental oxygen therapy in the preoperative period * Refusal to participate in the study or inability to comply with study procedures
Where it's running
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Ankara Etlik City Hospital
Ankara, Turkey (Türkiye) Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.