Optimizing Time-Limited Trials of Ventilation in Acute Respiration Failure
Official title: Optimizing Time-Limited Trials of Mechanical Ventilation in Acute Respiratory Failure: A Mixed Methods Observational Study
Funded at University of Wisconsin-Madison · NIH-11348199 · Data updated 2026-11-12
Aimed at patients with acute respiratory failure, this project looks at how short-term trials of life-support in the ICU can be better planned and communicated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $650,540 |
| NIH project number | 5R01HL168474-04 |
| Project ID | NIH-11348199 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with acute respiratory failure who may require life-sustaining treatment in the ICU and their surrogate decision makers.
✕Less likely to help
Patients not experiencing a time-limited trial scenario or those without a surrogate decision-maker involved in care decisions.
What this research studies
This study partners with patients, families, and ICU teams to refine how time-limited trials of life-sustaining ventilation are conducted. It uses mixed methods to understand current practices, barriers, and facilitators, then tests practical approaches to improve decision-making and alignment with patient goals. The goal is to create clearer processes that support patients, families, and clinicians during critical care decisions.
Why it matters
Potential benefit: If successful, it could make end-of-life ICU care more aligned with patient wishes and reduce uncertainty for families and care teams.
How similar studies have gone: Previous work shows promise in guiding end-of-life ICU care, but formalized, evidence-based practices for time-limited trials are still evolving.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Kruser, Jacqueline Marie — University of Wisconsin-Madison
- Study coordinator: Kruser, Jacqueline Marie
Related research
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This research looks at how a person's own breathing effort affects lung and diaphragm injury for adults on ventilators for acute respiratory failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.