Using electrical impedance tomography to guide PEEP settings in patients with moderate to severe ARDS
Official title: The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
Run by Vietnam Military Medical University · NCT06733168 · Data updated 2026-11-12
This study is testing if using a special imaging technique to set breathing support can help patients with severe lung issues breathe better and recover faster while on a ventilator.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 76 (estimated) |
| Sponsor | Vietnam Military Medical University Academic / other |
| Locations | 1 site (Hanoi) |
| Status | Recruiting |
| Started | August 15, 2024 |
| Main results expected | December 15, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | December 13, 2024 |
| Trial ID | NCT06733168 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult patients aged 18 and older who are intubated and diagnosed with moderate to severe ARDS.
✕Probably not a fit
Patients with unstable hemodynamics, recent chest trauma, or severe neuromuscular diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effects of PEEP settings guided by electrical impedance tomography (EIT) on patients with moderate to severe acute respiratory distress syndrome (ARDS) undergoing mechanical ventilation. It is a prospective, single-center, randomized controlled trial where participants will be divided into two groups: one receiving EIT-guided PEEP titration and the other following a conventional low FiO2-PEEP table. The primary outcomes focus on blood oxygenation and pulmonary mechanics, while secondary outcomes include mortality rates, length of ICU stay, and other respiratory variables. The study aims to optimize PEEP settings to improve patient outcomes and reduce the risk of ventilator-induced lung injury.
Why it matters
Potential benefit: If successful, this approach could significantly improve oxygenation and pulmonary mechanics in patients with ARDS, potentially reducing mortality rates.
How similar studies have gone: While the use of EIT in guiding PEEP settings is a novel approach, similar studies have shown promising results in optimizing mechanical ventilation strategies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Intubated moderate and severe ARDS according to the New Global Definition (PaO2/FiO2 ≤200 mmHg). * Used continuous sedation with or without paralysis. Exclusion Criteria: * Presence of pneumothorax that is either undrained or newly occurred. * Unstable hemodynamics with a mean arterial pressure \< 60 mmHg and unresponsive to resuscitation measures, and/or heart rate \< 60 bpm. * Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application). * Pregnancy. * Severe neuromuscular disease.
Where it's running
-
Intensive Care Center, Bach Mai Hospital
Hanoi, Vietnam Recruiting
Study contacts
- Study coordinator: Trung Van Dinh, MD
- Email: dinhvantrung.ptgh@gmail.com
- Phone: (+84) 988519190
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS
This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.
-
EIT-guided PEEP personalization for trauma- and postoperative ARDS
This trial tests whether using bedside electrical impedance tomography (EIT) to set PEEP helps adults with moderate to severe ARDS after trauma or major surgery breathe and oxygenate better.
-
Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation
This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.
-
Noninvasive estimate of inspiratory effort to monitor pressure support ventilation
This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.
-
Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery
In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.
-
Inspiratory Effort and Dyspnea During Assisted Mechanical Ventilation in Critically Ill Adults
This study tests how different patient breathing efforts relate to breathlessness in adults on assisted mechanical ventilation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.