Using electrical impedance tomography to guide PEEP settings in patients with moderate to severe ARDS
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
This study is testing if using a special imaging technique to set breathing support can help patients with severe lung issues breathe better and recover faster while on a ventilator.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 76 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Vietnam Military Medical University Academic / other |
| Locations | 1 site (Hanoi) |
| Trial ID | NCT06733168 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effects of PEEP settings guided by electrical impedance tomography (EIT) on patients with moderate to severe acute respiratory distress syndrome (ARDS) undergoing mechanical ventilation. It is a prospective, single-center, randomized controlled trial where participants will be divided into two groups: one receiving EIT-guided PEEP titration and the other following a conventional low FiO2-PEEP table. The primary outcomes focus on blood oxygenation and pulmonary mechanics, while secondary outcomes include mortality rates, length of ICU stay, and other respiratory variables. The study aims to optimize PEEP settings to improve patient outcomes and reduce the risk of ventilator-induced lung injury.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients aged 18 and older who are intubated and diagnosed with moderate to severe ARDS.
Not a fit: Patients with unstable hemodynamics, recent chest trauma, or severe neuromuscular diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve oxygenation and pulmonary mechanics in patients with ARDS, potentially reducing mortality rates.
How similar studies have performed: While the use of EIT in guiding PEEP settings is a novel approach, similar studies have shown promising results in optimizing mechanical ventilation strategies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Intubated moderate and severe ARDS according to the New Global Definition (PaO2/FiO2 ≤200 mmHg). * Used continuous sedation with or without paralysis. Exclusion Criteria: * Presence of pneumothorax that is either undrained or newly occurred. * Unstable hemodynamics with a mean arterial pressure \< 60 mmHg and unresponsive to resuscitation measures, and/or heart rate \< 60 bpm. * Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application). * Pregnancy. * Severe neuromuscular disease.
Where this trial is running
Hanoi
- Intensive Care Center, Bach Mai Hospital — Hanoi, Vietnam (Recruiting)
Study contacts
- Study coordinator: Trung Van Dinh, MD
- Email: dinhvantrung.ptgh@gmail.com
- Phone: (+84) 988519190
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.