Understanding reverse trigger in patients on mechanical ventilation
Incidence of Reverse Trigger Phenotypes and Response to Ventilatory Adjustments in Patients With ARDS
Hospital Civil de Guadalajara · NCT06148467
This study looks at how often patients with severe lung problems on mechanical ventilation experience a condition called reverse trigger, to see how it affects their treatment and recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 130 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Hospital Civil de Guadalajara (other) |
| Locations | 1 site (Guadalajara) |
| Trial ID | NCT06148467 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine the incidence of reverse trigger (RT) in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation. Participants will be monitored continuously using esophageal manometry to detect RT and assess their response to ventilatory adjustments. Data will be collected on various clinical parameters, including ventilator settings and patient outcomes, to better understand the dynamics of RT in this population. The study will involve trained investigators who will analyze ventilator waveforms and other metrics to characterize RT events.
Who should consider this trial
Good fit: Ideal candidates for this study are adults diagnosed with ARDS who are currently on mechanical ventilation.
Not a fit: Patients under 18 years old, those with tracheostomy status, pneumothorax, or tube thoracostomy with air leaks may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of mechanically ventilated patients with ARDS by identifying and addressing reverse trigger events.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have explored mechanical ventilation dynamics and their impact on patient outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of ARDS according to the Berlin criteria and added New Global Definition 2023 * Mechanical ventilation Exclusion Criteria: * \<18 years * Tracheostomy status * Pneumothorax * Tube thoracostomy with air leaks
Where this trial is running
Guadalajara
- Hospital Civil Fray Antonio Alcalde — Guadalajara, Mexico (RECRUITING)
Study contacts
- Principal investigator: Miguel Ibarra Estrada, MD — Hospital Civil Fray Antonio Alcalde
- Study coordinator: Miguel Ibarra-Estrada, MD
- Email: drmiguelibarra@hotmail.com
- Phone: +523317593502
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Reverse Trigger, Acute Respiratory Distress Syndrome, Mechanical Ventilation, Reverse trigger, Dyssynchony