Understanding reverse trigger in patients on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine the incidence of reverse trigger (RT) in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation. Participants will be monitored continuously using esophageal manometry to detect RT and assess their response to ventilatory adjustments. Data will be collected on various clinical parameters, including ventilator settings and patient outcomes, to better understand the dynamics of RT in this population. The study will involve trained investigators who will analyze ventilator waveforms and other metrics to characterize RT events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of ARDS according to the Berlin criteria and added New Global Definition 2023
* Mechanical ventilation

Exclusion Criteria:

* \<18 years
* Tracheostomy status
* Pneumothorax
* Tube thoracostomy with air leaks

Where it's running

• Hospital Civil Fray Antonio Alcalde
  Guadalajara, Mexico Recruiting

Study contacts

• Principal investigator: Miguel Ibarra Estrada, MD — Hospital Civil Fray Antonio Alcalde
• Study coordinator: Miguel Ibarra-Estrada, MD
• Email: drmiguelibarra@hotmail.com
• Phone: +523317593502

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effect of expiratory time constant (RCexp) on lung ventilation and blood flow in ventilated ARDS patients

  This tests whether the expiratory time constant (RCexp) changes how air and blood are distributed in the lungs of adults with ARDS who are on mechanical ventilation.

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• Observing physiological changes in ARDS patients in the prone position

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• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation

  This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.

  Recruiting Capital Medical University · Beijing · NCT07886918

• Noninvasive estimate of inspiratory effort to monitor pressure support ventilation

  This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.

  Recruiting Capital Medical University · Beijing · NCT07886892

• Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery

  In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.

  Recruiting Hopital Charles Nicolle · Tunis · NCT07885124

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.