Driving-pressure guided ventilation versus lung-protective ventilation during elective laparoscopic surgery
Official title: A Comparison of Driving Pressure Guided Mechanical Ventilation With Lung Protective Ventilation Among Patients Presenting for Elective Surgeries at a Tertiary Care Hospital; A Randomized Control Trial
Run by Rawalpindi Medical College · NCT07092943 · Data updated 2026-11-12
We will test if adjusting the ventilator to keep the driving pressure under 15 cm H2O helps adults having elective laparoscopic surgery breathe better while under general anesthesia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years to 80 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Rawalpindi Medical College Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | July 20, 2025 |
| Main results expected | October 20, 2025 |
| Study ends | October 20, 2025 |
| Registry record updated | July 30, 2025 |
| Trial ID | NCT07092943 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults classified ASA I–II having elective laparoscopic surgery under general anesthesia with neuromuscular blockade who will need mechanical ventilation for at least one hour and have BMI ≤35 kg/m2.
✕Probably not a fit
Patients unlikely to benefit include pregnant people, those with BMI >35 kg/m2, active smokers, ASA class III or higher, recent invasive mechanical ventilation within two weeks, or those undergoing thoracic or cardiac surgery.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing elective laparoscopic surgery under general anesthesia and neuromuscular blockade are assigned to receive either standard lung-protective ventilation (tidal volumes 6–8 ml/kg ideal body weight, PEEP ~5 cm H2O, plateau pressure <30 cm H2O) or a driving-pressure guided strategy where PEEP is adjusted to keep the difference between plateau pressure and PEEP (driving pressure) ≤15 cm H2O. Ventilation is continued for the duration of the operation when mechanical ventilation is required for at least one hour. The protocol focuses on intraoperative ventilator settings and monitors airway pressures and standard respiratory parameters. Outcomes include intraoperative lung mechanics and markers of postoperative pulmonary complications and safety events.
Why it matters
Potential benefit: If successful, this approach could reduce ventilator-related stress on the lungs during surgery and lower the risk of postoperative breathing problems.
How similar studies have gone: Some critical care studies have linked lower driving pressure with better outcomes, but using driving-pressure guidance specifically during routine elective surgery is not yet well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) class: I and II. * Elective laparoscopic surgeries requiring General Anesthesia and Mechanical ventilation * Patients receiving neuromuscular blockade during surgery. * Receiving Mechanical ventilation for at least 1h. Exclusion Criteria: * Pregnancy * Patients who had received mechanical ventilation of more than 1h in the previous 2 weeks. * Body mass index \>35 kg/m2 * Smokers and ASA class III and above. * Thoracic and Cardiac surgery
Where it's running
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Benazir Bhutto Hospital
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Huda Tariq, MBBS
- Email: Huda8829@gmail.com
- Phone: +92-321-8829413
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.