Investigating how mechanical ventilation affects children with severe lung injury
Official title: Mechanical Ventilation Management, New or Progressive MODS, and Post-ICU Morbidity in Pediatric ARDS
Funded at Children's Hospital of Los Angeles · NIH-11064085 · Data updated 2026-11-12
This study is looking at how different ways of using breathing machines affect children with serious lung problems, hoping to find better ways to help them recover and avoid complications after their time in intensive care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $127,440 |
| NIH project number | 5K23HL153756-05 |
| Project ID | NIH-11064085 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who are experiencing pediatric acute respiratory distress syndrome and require mechanical ventilation.
✕Less likely to help
Patients who are not experiencing acute respiratory distress or are older than 11 years may not benefit from this research.
What this research studies
This research focuses on understanding the impact of mechanical ventilation practices on children suffering from pediatric acute respiratory distress syndrome (PARDS). The study aims to explore the relationship between injurious ventilation techniques and the development of new or progressive multiple organ dysfunction syndrome (NPMODS), which may lead to complications after intensive care. By analyzing data from a larger trial involving 276 children, the research seeks to identify how these factors contribute to post-ICU morbidity, ultimately aiming to improve care strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved mechanical ventilation practices that reduce complications and enhance recovery for children with severe lung injuries.
How similar studies have gone: Previous research in adult populations has shown that harmful mechanical ventilation practices can lead to increased mortality, suggesting that similar investigations in pediatric populations could yield valuable insights.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Bhalla, Anoopindar — Children's Hospital of Los Angeles
- Study coordinator: Bhalla, Anoopindar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.