Clinical trial Recruiting at 1 site Observational Ages 18 to 90

Observing physiological changes in ARDS patients in the prone position

Official title: The Respiratory Physiologic Efficacy of Prone Position and Its Association With Outcomes in ARDS: A Prospective Observational Cohort Study

Run by West China Hospital · NCT06586736 · Data updated 2026-11-12

This study looks at how lying on the stomach affects breathing and oxygen levels in patients with Acute Respiratory Distress Syndrome to see if it can help improve their recovery.

Quick facts

Study typeObservational
Ages18 Years to 90 Years
SexAll
Enrollment100 (estimated)
SponsorWest China Hospital
Academic / other
Locations1 site (Chengdu, Sichuan)
StatusRecruiting
StartedSeptember 1, 2023
Main results expectedJune 2025
Study endsJune 2025
Registry record updatedMarch 3, 2025
Trial IDNCT06586736 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are intubated patients aged 18 and older with moderate to severe ARDS who are undergoing mechanical ventilation and prone positioning.

Probably not a fit

Patients who may not benefit from this study include those with cardiac structural shunts, pulmonary embolism, or those undergoing extracorporeal membrane oxygenation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to monitor physiological indicators such as ventilation and oxygenation in patients with Acute Respiratory Distress Syndrome (ARDS) who are placed in the prone position. It seeks to identify trends in these indicators to determine their predictive value for patient prognosis. The study will focus on the relationship between ventilation/perfusion ratios and patient outcomes, particularly in the context of mechanical ventilation. By analyzing these changes, the research hopes to provide insights into which patients may benefit from prone positioning.

Why it matters

Potential benefit: If successful, this study could help identify which ARDS patients are most likely to benefit from prone positioning, potentially improving their outcomes.

How similar studies have gone: Previous studies have shown that prone positioning can improve outcomes in severe ARDS, but this study aims to refine the understanding of which patients benefit most, making it a novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Intubated patients
2. Undergoing mechanical ventilation
3. Moderate to severe ARDS
4. Undergoing prone positioning
5. Age≥18 years old

Exclusion Criteria:

1. Pregnant
2. Cardiac structural shunt
3. Extracorporeal membrane oxygenation performed
4. Undergo extracorporeal CO2 removal
5. Pulmonary embolism
6. Other situation that may affect the accuracy of PetCO2 monitoring
7. Prone positioning session less than 10 hours

Where it's running

  • Department of Critical care medicine of West China Hospital
    Chengdu, Sichuan, China
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.