Observing physiological changes in ARDS patients in the prone position
The Respiratory Physiologic Efficacy of Prone Position and Its Association With Outcomes in ARDS: A Prospective Observational Cohort Study
West China Hospital · NCT06586736
This study looks at how lying on the stomach affects breathing and oxygen levels in patients with Acute Respiratory Distress Syndrome to see if it can help improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | West China Hospital (other) |
| Locations | 1 site (Chengdu, Sichuan) |
| Trial ID | NCT06586736 on ClinicalTrials.gov |
What this trial studies
This observational study aims to monitor physiological indicators such as ventilation and oxygenation in patients with Acute Respiratory Distress Syndrome (ARDS) who are placed in the prone position. It seeks to identify trends in these indicators to determine their predictive value for patient prognosis. The study will focus on the relationship between ventilation/perfusion ratios and patient outcomes, particularly in the context of mechanical ventilation. By analyzing these changes, the research hopes to provide insights into which patients may benefit from prone positioning.
Who should consider this trial
Good fit: Ideal candidates for this study are intubated patients aged 18 and older with moderate to severe ARDS who are undergoing mechanical ventilation and prone positioning.
Not a fit: Patients who may not benefit from this study include those with cardiac structural shunts, pulmonary embolism, or those undergoing extracorporeal membrane oxygenation.
Why it matters
Potential benefit: If successful, this study could help identify which ARDS patients are most likely to benefit from prone positioning, potentially improving their outcomes.
How similar studies have performed: Previous studies have shown that prone positioning can improve outcomes in severe ARDS, but this study aims to refine the understanding of which patients benefit most, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Intubated patients 2. Undergoing mechanical ventilation 3. Moderate to severe ARDS 4. Undergoing prone positioning 5. Age≥18 years old Exclusion Criteria: 1. Pregnant 2. Cardiac structural shunt 3. Extracorporeal membrane oxygenation performed 4. Undergo extracorporeal CO2 removal 5. Pulmonary embolism 6. Other situation that may affect the accuracy of PetCO2 monitoring 7. Prone positioning session less than 10 hours
Where this trial is running
Chengdu, Sichuan
- Department of Critical care medicine of West China Hospital — Chengdu, Sichuan, China (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Respiratory Distress Syndrome, Mechanical Ventilation, Prone Positioning, Prone positioning, ARDS, Dead space ratio, Ventilatory ratio, Ventilation/perfusion