Bedside bronchoscopy to clear airways in adults on ventilation with atelectasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized study, adults on invasive mechanical ventilation with atelectasis and high airway secretions receive either standard airway care plus bedside flexible bronchoscopy-guided airway clearance or standard airway care alone. The team will assess changes in the amount of nonaerated lung tissue by day 5 and look at respiratory mechanics, blood gases, infection scores, ventilator-free days, ICU stay, and safety. Participants are randomly assigned after meeting criteria and providing consent. The intervention uses flexible bronchoscopy to assist airway clearance at the bedside. The trial is conducted at Zhongda Hospital, Southeast University, with Southeast University as the lead sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18 years or older
2. Receiving invasive mechanical ventilation for at least 48 hours
3. Presence of atelectasis confirmed by chest computed tomography, chest X-ray, or lung ultrasound
4. High airway secretion burden, defined as requiring airway suctioning at least twice per hour during the previous 8 hours
5. Written informed consent obtained from the participant or legally authorized representative

Exclusion Criteria:

1. Expected duration of artificial airway maintenance less than 5 days
2. Untreated tension pneumothorax
3. Large pleural effusions requiring thoracentesis.
4. Known or suspected aspiration
5. Active intrapulmonary hemorrhage
6. Severe dysfunction of other organs with expected short-term mortality within 7 days or need for palliative care
7. Any other condition judged by the medical team to make the participant unsuitable for the study
8. Informed consent not obtained

Where it's running

• Zhongda Hospital, Southeast University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Ling Liu, PHD — Zhongda Hospital, School of Medicine, Southeast University
• Study coordinator: Mengyuan Shen, MD
• Email: Smy0116tu@163.com
• Phone: +8615996997839

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.