Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares two electrical impedance tomography (EIT) methods—pulse wave EIT and saline bolus EIT—for assessing pulmonary perfusion in adults with ARDS who are mechanically ventilated. It also explores how different positive end-expiratory pressure (PEEP) levels affect perfusion imaging accuracy. Real-time, bedside imaging aims to enhance understanding of ventilation-perfusion status to support individualized, precision care. The trial leverages noninvasive EIT signals to monitor dynamic cardiopulmonary physiology during critical illness. Participants meet criteria typical for severe ARDS requiring intubation and venous access, with exclusions to minimize risk and confounding conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age: 18-80 years;
2. Endotracheal intubation and mechanical ventilation;
3. Presence of a subclavian or internal jugular venous catheter in place;
4. Diagnosis of ARDS according to the 2023 global ARDS definition.

Exclusion Criteria:

1. Age \<18 or \>80 years;
2. Severe obesity (BMI ≥35 kg/m²);
3. Pregnant or lactating women;
4. Pulmonary diseases: acute asthma exacerbation, COPD, pulmonary fibrosis, pleural effusion, pneumothorax, or pulmonary embolism;
5. Cardiac diseases: arrhythmias, significant valvular regurgitation, or cardiac dysfunction (LVEF \<50% or right ventricular dysfunction);
6. Hypernatremia;
7. Receiving ECMO therapy;
8. Failure to provide informed consent.

Where it's running

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Xue Tian, MD
• Email: m202376326@hust.edu.cn
• Phone: 027-85351606

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.