Pain management approach for trauma patients on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of an analgesia-first sedation strategy compared to traditional continuous sedation in trauma patients requiring mechanical ventilation. It will assess the impact of these different sedation approaches on the duration of mechanical ventilation and overall patient comfort. The study will involve patients aged 18 and older who are expected to be on mechanical ventilation for at least 48 hours and will utilize protocol-directed sedation with daily interruptions. The goal is to determine which method leads to better outcomes in terms of ventilation duration and ICU stay.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ≥ 18 years of age
2. Mechanically ventilated with an expected duration of MV ≥ 48h
3. Initiated continuous sedative/analgesic infusions by the ICU team
4. Patient is a candidate for MV weaning

Exclusion Criteria:

1. Admission after resuscitation from cardiac arrest
2. Significant neurological deficit due to a chronic disorder
3. History of alcohol dependence and/or other illicit drug abuse
4. Prior administration of continuous sedative/analgesic from a transferring institution
5. Patient receiving neuromuscular blocking agents
6. Allergy to midazolam, lorazepam, and/or propofol

Where it's running

• Long Beach Memorial Medical Center
  Long Beach, California, United States Recruiting

Study contacts

• Principal investigator: Maged Tanios, MD, MPH — Long Beach Memorial Medical Center
• Study coordinator: Maged Tanios, MD, MPH
• Email: tanios@memorialcare.org
• Phone: 562-424-800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.