Investigating how a protein affects lung function during mechanical ventilation
Official title: Post-Translational Modification of Annexin A2 Mediates Surfactant Dysfunction During Injurious Mechanical Ventilation
Funded at Ohio State University · NIH-10998167 · Data updated 2026-11-12
This study is looking at how a protein changes when patients with acute respiratory distress syndrome (ARDS) are on mechanical ventilation, and how these changes might affect lung function, with the hope of finding better treatments to help ARDS patients breathe easier.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $86,932 |
| NIH project number | 1F32HL176082-01 |
| Project ID | NIH-10998167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute respiratory distress syndrome who require mechanical ventilation.
✕Less likely to help
Patients with chronic respiratory conditions or those not requiring mechanical ventilation may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, annexin A2, is modified during mechanical ventilation, which is often necessary for patients with acute respiratory distress syndrome (ARDS). The study aims to explore how these modifications lead to dysfunction in pulmonary surfactant, a substance crucial for proper lung function. Using both animal models and innovative human-based technology, the research will examine the mechanisms behind this dysfunction and seek to identify potential new treatment targets. The ultimate goal is to improve outcomes for patients suffering from ARDS by mitigating the harmful effects of mechanical ventilation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and survival rates for patients with ARDS.
How similar studies have gone: Previous research has shown promising results in understanding surfactant dysfunction in ARDS, but this specific approach using annexin A2 is novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Bentley, Ian — Ohio State University
- Study coordinator: Bentley, Ian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.