Understanding long-term outcomes for children on mechanical ventilation
Official title: Functional Outcomes after Prolonged Mechanical Ventilation in Children
Funded at University of Colorado Denver · NIH-10663936 · Data updated 2026-11-12
This study looks at how kids who needed long-term breathing support due to serious lung issues are doing over time, focusing on their recovery and quality of life after they leave the hospital.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $160,664 |
| NIH project number | 5K23HD096018-05 |
| Project ID | NIH-10663936 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 21 years old who have experienced prolonged mechanical ventilation due to critical respiratory conditions.
✕Less likely to help
Patients who have not undergone mechanical ventilation or who are over 21 years old may not benefit from this research.
What this research studies
This research investigates the long-term functional outcomes of children who have required prolonged mechanical ventilation due to severe respiratory conditions. By analyzing data from both hospital records and outpatient claims, the study aims to identify patterns in recovery and the factors that influence these outcomes. Additionally, a new group of critically ill children will be monitored to assess their quality of life and physical functioning after discharge. This comprehensive approach seeks to fill the knowledge gap regarding the effects of mechanical ventilation on children's health over time.
Why it matters
Potential benefit: If successful, this research could lead to improved care strategies and support for children recovering from severe respiratory illnesses.
How similar studies have gone: Previous research on adult survivors of mechanical ventilation has shown significant long-term impairments, suggesting that similar findings may be expected in children, though this specific focus on pediatric outcomes is less explored.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Maddux, Aline Bernard — University of Colorado Denver
- Study coordinator: Maddux, Aline Bernard
Related research
Other NIH-funded projects on the same topics.
-
Advancing Acute Respiratory Infection Care for Kids on Home Ventilators
This grant aims to improve how doctors and families manage acute respiratory infections in children who rely on invasive long-term home ventilation.
-
A Tablet-Based Emotion Regulation Program for Surrogate Decision-Makers of ICU Patients on Ventilation
A randomized trial tests a brief tablet program to help people who decide for ICU patients on ventilation feel less anxious and make better decisions.
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Optimizing pain relief for children on mechanical ventilation
A large, multi-site trial tests whether adding non-opioid pain medicines to standard opioid care can reduce pain and lower opioid use in children on breathing machines in PICUs.
-
Role of titin in diaphragm weakness during mechanical ventilation
This grant studies how the diaphragm’s core proteins work together, especially titin and myosin, to understand why diaphragm weakness happens during mechanical ventilation.
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Time-limited trials to guide invasive ventilation decisions
A scientific team is testing how short, structured trials of life-support in ICU patients with acute respiratory failure can help patients and families choose the best path.
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How breathing machines can harm the kidneys
Doctors will look at how ventilators change kidney filtering and salt handling in people who are critically ill to help prevent kidney damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.