Condition

Metabolic Syndrome clinical trials and research

• 113Clinical trials
• 58NIH research projects
• 2New in 30 days
• 37Countries

Newest Metabolic Syndrome clinical trials

All recruiting trials (113)

• Fulvic acid supplements for metabolic syndrome

  This study tests whether 50 mg or 100 mg of fulvic acid daily for 12 weeks can help people with metabolic syndrome or prediabetes.

  Recruiting Arizona State University · Phoenix, Arizona · NCT07927283

• Asprosin and miRNA Profiles in Young Women with Metabolic Syndrome

  This study tests whether certain blood biomarkers, including asprosin and six microRNAs, differ between young women with metabolic syndrome and healthy peers.

  Recruiting University of Applied Sciences in Nowy Targ · Nowy Targ, Lesser Poland Voivodeship · NCT07917364

• Using Multimodal Ultrasound to Check Muscle Mass in Metabolic Disease Patients

  This study tests whether a multimodal ultrasound approach can accurately measure muscle mass in people with metabolic syndrome, obesity, sarcopenia, or type 2 diabetes.

  Recruiting Zhangzhou Municipal Hospital · Zhangzhou, Fujian · NCT07836088

• Low-Calorie Diet in adolescents with Familial Mediterranean Fever and metabolic syndrome

  A group of adolescents with both FMF and metabolic syndrome will try a low-calorie diet for 3 months to see if it helps manage metabolic symptoms.

  Recruiting Cairo University · Giza, Dokki · NCT07833007

• Exercise for Metabolic Syndrome and Fatty Liver in Adolescent Girls with Celiac Disease

  This study tests whether a 3-month walking program helps improve metabolic syndrome and fatty liver in adolescent females with celiac disease.

  Recruiting Cairo University · Giza, Dokki · NCT07832994

• Longevity Metrics AI/ML Development Study

  Researchers are testing AI models that score health screening tests and predict outcomes like life expectancy for adults, using ongoing follow-up data.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07808619

• Cardiorespiratory and muscular fitness in children with obesity and autism

  This study tests whether cardiorespiratory fitness and handgrip strength differ between children with obesity who have autism and those who do not, and how these fitness measures relate to body size, composition, and cardiometabolic health.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07804680

• Lifestyle changes to improve erectile function in men with metabolic syndrome

  A six-month lifestyle program is being tried to see if it improves erectile function and penile blood flow in men who have erectile dysfunction linked to metabolic syndrome.

  Recruiting at 2 sites Al-Azhar University · Cairo and 1 other locations · NCT07758842

• Digital dietary help for people on GLP-1 therapy to reach better blood sugar and weight

  This trial tests whether adding a digital dietary program (NutriSteppe) to usual care helps adults on GLP-1 medications see better blood sugar control and weight results.

  Recruiting Kazakh Academy of Nutrition · Almaty · NCT07728669

• Kodo Millet Porridge and Gut Health in Overweight and Obese Adults

  This study tests whether daily intake of Kodo millet porridge for 12 weeks can improve gut bacteria and metabolic health in adults who are overweight or obese.

  Recruiting Jss Medical College, Jss Academy of Higher Education and Research · Mysore, Karnataka · NCT07703371

• Physical activity program for women with metabolic syndrome and Behçet disease

  This study tests whether a structured treadmill walking program helps women with metabolic syndrome and Behçet disease compared with a waitlist group.

  Recruiting Cairo University · Giza, Dokki · NCT07702123

• Health Ahead: Comparing AI vs. Humans for Preventive Health Screening

  This study tests AI-assisted screening interpretation against human-only reads to see if automated screening can match or improve current practice for adults, especially in underserved areas.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07669168

• Personality Traits and Biochemical Risk Markers in Routine Health Assessments

  This study tests whether personality traits relate to the number of abnormal lab results found during a standard health checkup in adults.

  Recruiting Medical Center TOPMED · Târgu Mureş, Mureș County · NCT07653048

• How environment and biology together predict health, aging, and death

  Researchers are following adults to see how living conditions and biology together relate to aging and life expectancy, by linking personal health data with environmental and social information over time.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07646782

• Galantamine treatment for metabolic syndrome in people with spinal cord injury

  This study tests whether galantamine can help reduce metabolic syndrome and inflammation in adults with chronic spinal cord injury.

  Recruiting at 2 sites Phase 2/3 Northwell Health · West Orange, New Jersey and 2 other locations · NCT07625332

• Metabolic Health Trajectories in Overweight Chinese Adults

  This observational study follows overweight and obese Chinese adults to see how metabolic health changes over five years and whether people stay healthy, develop diabetes, or have complications.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT07584330

• Short versus long intermittent hypoxic-hyperoxic training for people with type 2 diabetes, including older adults

  This study will see if short (3-day) or longer (10-day) sessions of intermittent low-oxygen/high-oxygen breathing improve blood sugar control in people aged 50–74 with type 2 diabetes.

  Recruiting National Medical Research Center for Therapy and Preventive Medicine · Moscow · NCT07574333

• 100-Year Human Aging and Longevity Tracking Program

  This project will follow adults over their lifetimes to see if repeated health tests can predict lifespan, causes of death, serious disease, and loss of function.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07563777

• Low-energy shock wave treatment for overactive bladder in women with metabolic syndrome

  This trial tests whether low-energy extracorporeal shock wave therapy (LiESWT) can reduce urgency, daytime frequency, and nighttime urination in women who have metabolic syndrome.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung, Taiwan · NCT07563764

• Rise & Thrive: a community-engagement program to help youth manage stress and depressive symptoms

  A group-based program tests whether community engagement activities can help Black and/or Hispanic/Latine youth aged 15-20 see reductions in depressive symptoms.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT07554326

• Rutazyme lemon fermented capsules for metabolic health in adults with obesity

  This will test whether taking a Rutazyme lemon fermented capsule each night can help improve metabolic health in adults with obesity.

  Recruiting National Taiwan Sport University · Taoyuan · NCT07540949

• Functional foods with antioxidants, prebiotic fiber, oat beta‑glucan and omega‑3 for people at risk of metabolic syndrome

  This trial will test whether daily functional foods containing antioxidants, prebiotic fiber, oat beta‑glucan, and omega‑3s can lower post-meal blood sugar and improve weight, lipids, and oxidative markers in adults at risk for metabolic syndrome.

  Recruiting Dr. Schär AG / SPA · Bolzano, Bolzano · NCT07505277

• H. pylori and insulin resistance in people with metabolic syndrome

  This project will test whether people with metabolic syndrome who still have H. pylori infection have worse insulin resistance (measured by HOMA-IR) than similar patients without the infection.

  Recruiting Center of New Medical Technologies · Novosibirsk, Novosibirsk Oblast · NCT07501858

• Cranberry for gut and metabolic health in adults with overweight or obesity

  This study will test whether drinking a cranberry beverage can improve blood sugar control, insulin sensitivity, blood lipids, and gut microbiota in adults with overweight or obesity who have metabolic risk factors.

  Recruiting Laval University · Québec, Quebec · NCT07460856

• Blood-count inflammation scores (SII and SIRI) to predict metabolic complications in adults with overweight or obesity

  This project will test whether two blood-count-based scores (SII and SIRI) can help predict metabolic complications and treatment response in adults with overweight or obesity.

  Recruiting University of Rijeka · Varaždin · NCT07431593

• Exercise effects on carotid artery function in young adults with metabolic syndrome

  This study will test if a single 30-minute bout of moderate exercise can quickly improve internal carotid artery endothelial function in young adults with metabolic syndrome and whether effects differ by sex.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07430839

• Emotional Eating, Sleep Quality, Mental State, and Metabolic Syndrome in Psychiatric Patients

  This study tests how mood, sleep, and emotional eating relate to metabolic syndrome in people with schizophrenia or bipolar disorder.

  Recruiting Abant Izzet Baysal University · Bolu, Bolu · NCT07411222

• Community health coach plus AI app program to help people with metabolic syndrome manage diet and heart risk

  This program will test whether a community health coach working with an AI-powered app can help adults with metabolic syndrome improve their eating habits, self-control, and cardiovascular risk.

  Recruiting National University Health System, Singapore · Singapore · NCT07410325

• How whole-fat versus low-fat milk affects adults with metabolic syndrome

  This trial will test whether drinking whole-fat milk compared with low-fat milk changes heart and metabolic risk factors and blood vessel function in adults with metabolic syndrome.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07401888

• Time-restricted eating plus psychochrononutrition for people with metabolic syndrome

  This trial will test whether adding a psychochrononutritional program to time‑restricted eating helps adults with metabolic syndrome stick to the eating schedule and improve waist size, blood pressure, lipids, and blood sugar.

  Recruiting University of Guadalajara · Ciudad Guzmán, Jalisco · NCT07389603

• Electrical stimulation plus isometric exercise to improve blood flow in resistant high blood pressure

  This will try whether adding upper‑thoracic electrical stimulation (TENS) and isometric exercise to usual blood pressure medications can lower blood pressure and improve peripheral blood flow in men and women aged 50–60 with resistant hypertension.

  Recruiting Cairo University · Port Said, Port Said Governorate · NCT07383220

• Faster versus controlled weight training after a kidney transplant

  This trial will test whether doing resistance exercises quickly versus more slowly for 12 weeks improves kidney health, metabolic markers, and strength in adults who have had a kidney transplant.

  Recruiting Fundación Universitaria del Area Andina · Bogotá, Bogota D.C. · NCT07370727

• How moderate wine drinking affects healthy aging through post-meal extracellular vesicles

  This test will see if a single serving of red or white wine changes circulating extracellular vesicles in healthy adults aged 35–65.

  Recruiting University of Seville · Seville, Sevilla · NCT07361887

• Empagliflozin for metabolic health in adults with HIV on dolutegravir

  This trial tests whether the diabetes medicine empagliflozin can help reduce obesity-related metabolic problems in adults living with HIV who are taking dolutegravir-based antiretroviral therapy.

  Recruiting Phase 2 Cairo University · Cairo · NCT07336797

• Breath mass spectrometry test to distinguish metabolic syndrome and metabolically healthy obesity

  This project will test whether a breath mass spectrometry test can tell apart adults with metabolic syndrome, adults with metabolically healthy obesity, and healthy-weight adults.

  Recruiting I.M. Sechenov First Moscow State Medical University · Moscow · NCT07330297

• Photoacoustic and ultrasound imaging of brown fat activity

  This project will test a radiation-free photoacoustic and ultrasound scan to see if it can measure brown fat activity in healthy adults and people with metabolic syndrome.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT07327684

• Treating H. pylori infection to help metabolic syndrome by changing gut bacteria.

  This study will see if adding a probiotic or berberine to standard H. pylori treatment helps adults with H. pylori infection and newly diagnosed metabolic syndrome improve blood sugar, cholesterol, weight, and other metabolic measures.

  Recruiting Phase 4 Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT07306988

• Using virtual reality to trigger exercise-like responses in sedentary adults

  This study will test whether repeated short VR sessions that mimic exercise can produce exercise-like protein changes and improved endurance in sedentary adults with prediabetes.

  Recruiting Wayne State University · Detroit, Michigan · NCT07296991

• Adding aerobic exercise to cognitive behavioural therapy for men with heavy drinking, metabolic syndrome, and impotence

  This study will test whether adding regular supervised aerobic exercise to cognitive behavioural therapy helps men who drink heavily and have metabolic syndrome and impotence.

  Recruiting Cairo University · Giza, Dokki · NCT07277673

• Long-term follow-up for adults with metabolic syndrome and prediabetes

  This project will follow adults with metabolic syndrome or prediabetes over time to see which lifestyle, metabolic, and nutritional factors predict progression to diabetes and related complications.

  Recruiting National Taiwan University Hospital · Taipei, Zhongzheng Dist · NCT07243821

• ERCG (clip-and-loop endoscopic gastric reduction) versus optimized lifestyle for weight loss

  This trial will test whether ERCG, a sutureless endoscopic clip-and-loop procedure that reduces stomach volume, helps Chinese adults with BMI 24.0–37.4 kg/m² lose more weight than an optimized lifestyle program.

  Recruiting Beijing 302 Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07237750

• Nattokinase for cardiovascular risk, gut bacteria, sleep, and thinking in people with metabolic syndrome and sleep apnea

  This trial will test whether taking nattokinase daily helps lower heart disease risk markers, change gut bacteria, improve sleep, and support thinking in adults with metabolic syndrome risk and mild-to-moderate sleep apnea.

  Recruiting Taipei Medical University · Taipei · NCT07229521

• Our Voices Matter: racial-justice activism program to reduce depression in Black and Latinx youth

  This program tests whether participating in racial-justice activism can reduce depressive symptoms and stress-related physical risk in Black and Latinx youth ages 15-20.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT07216326

• Long-term effects of time-restricted eating on cardiometabolic health

  This 54-week study will test if limiting daily eating to an 8–12 hour window helps adults with metabolic syndrome and pre-diabetes improve blood sugar, cholesterol, blood pressure, and body composition.

  Recruiting Phase 2 University of California, San Diego · La Jolla, California · NCT07189234

• Neonatal BNP and metabolic syndrome risk in adolescents

  This project will see if newborn BNP levels and early heart ultrasound measurements are linked to metabolic syndrome in adolescents who had those tests as infants.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, pavia · NCT07181733

• Intermittent fasting with calorie restriction and exercise for adults with metabolic syndrome

  This program will test whether combining intermittent fasting, reduced calories, and increased physical activity helps adults with metabolic syndrome improve blood sugar, blood pressure, cholesterol, and weight.

  Recruiting Universiti Putra Malaysia · Serdang, Selangor · NCT07181655

• Metabolic health and liver disease in Polish twins

  This project will follow Polish twins aged 15–44 for five years to see if family history, prior COVID-19, or other factors predict new fatty liver (MASLD), liver fibrosis/cirrhosis, or other metabolic syndrome complications.

  Recruiting Poznan University of Medical Sciences · Poznan, Wielkopolska · NCT07181018

• Ambient air and noise effects on heart and metabolic health with green-space exercise and Mediterranean diet (METSGREEN)

  This project will test whether exposure to ultrafine air pollution and urban noise raises heart and metabolic risk and whether daily green-space exercise or a Mediterranean diet can lower that risk in 45–64-year-old Kaunas residents with early metabolic problems.

  Recruiting Vytautas Magnus University · Kaunas, Kaunas County and 1 other locations · NCT07111208

• Pre-screening to identify adults who may be eligible for future metabolic and mental health opportunities.

  This prescreening will see if adults with metabolic conditions or mental health disorders qualify for upcoming clinical opportunities by collecting health history, basic tests, and a doctor interview.

  Recruiting Clindove Research LLC · Brooklyn, New York · NCT07106879

• Supplemental inulin fiber for gut and vascular health in adults with obesity

  This will try 9 weeks of inulin fiber to see if it improves gut health and blood vessel function in adults with obesity who are either metabolically healthy or metabolically abnormal.

  Recruiting Ball State University · Muncie, Indiana · NCT07095426

• Heart, kidney, and metabolic health in Shanghai community residents

  This follow-up will track people from the STONE cohort to see if changes in metabolic risk factors over time relate to heart and kidney outcomes.

  Recruiting Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT07043166

• Immersive virtual reality training to improve thinking and memory in adults with metabolic syndrome

  This project will try immersive virtual reality sessions that combine cognitive exercises and physical activity to see if they improve thinking and memory in middle-aged adults with metabolic syndrome who report cognitive complaints.

  Recruiting Consorci Sanitari de Terrassa · Terrassa · NCT07040748

• DTG/3TC versus BIC/TAF/FTC as first-line HIV treatment for people new to antiretrovirals

  This trial will test whether DTG/3TC gives similar viral control but less weight gain and metabolic side effects than BIC/TAF/FTC in adults newly starting HIV treatment.

  Recruiting Phase 4 Instituto Mexicano del Seguro Social · Mexico City, Azcapotzalco · NCT07031063

• Lifestyle changes and CPAP for men with sleep apnea and metabolic issues

  This study is testing if combining lifestyle changes like diet and exercise with CPAP therapy can help men with sleep apnea and metabolic issues feel better.

  Recruiting Cairo University · Giza, Dokki · NCT06960746

• Daily intake of short-chain fatty acids and its effects on metabolic health

  This study is testing whether drinking a daily beverage with short-chain fatty acids can help people at risk for metabolic syndrome improve their heart and metabolic health over 12 weeks.

  Recruiting KU Leuven · Leuven, Vlaams-Brabant · NCT06951386

• Investigating cardiovascular markers in women with PCOS during glucose testing

  This study is testing how glucose testing affects heart health markers in women with PCOS and whether different treatments can improve those markers over six months.

  Recruiting Attikon Hospital · Chaïdári · NCT06889454

• Effects of intermittent fasting and exercise on inflammation and metabolism in metabolic syndrome

  This study is testing if intermittent fasting alone or with high-intensity exercise can reduce inflammation and improve metabolism in people with obesity and metabolic syndrome.

  Recruiting University of Erlangen-Nürnberg Medical School · Erlangen, Bavaria · NCT06885255

• Calorie-reduced Mediterranean diet plus activity program to lower chronic disease risk in 30–50-year-olds

  This program will try a 25% calorie-reduced Mediterranean diet combined with increased physical activity to help 30–50-year-olds with metabolic syndrome lose weight and improve cardiometabolic health.

  Recruiting IMDEA Food · Madrid, Madrid · NCT06857929

• Low‑dose oral contraceptives plus resistant starch for metabolic health in PCOS

  This study will test whether adding resistant starch to standard low‑dose oral contraceptives improves cardiometabolic markers and the gut microbiome in overweight women aged 18–40 with PCOS.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06852365

• Program to promote lifestyle changes in people with metabolic syndrome

  This study tests a personalized program to help Chinese adults with metabolic syndrome make lifestyle changes and see if it improves their health over 12 weeks.

  Recruiting The University of Hong Kong · Hong Kong · NCT06793930

• Endoscopic conversion of sleeve gastrectomy to a new bypass method for reflux and obesity

  This study is testing a new, less invasive procedure to help people who haven't lost enough weight or have gained weight back after sleeve gastrectomy by converting it to a different type of bypass surgery.

  Recruiting at 3 sites Singapore Health Services · Singapore and 2 other locations · NCT06757296

• Investigating inflammation's role in heart disease and diabetes

  This study is testing how inflammation affects heart disease and diabetes in people who are healthy compared to those who are severely obese, to see if it can help identify who might benefit from new treatments.

  Recruiting University of Aarhus · Aarhus · NCT06752018

• Outreach program to improve engagement in a wellness initiative for metabolic syndrome

  This study is testing if a new way of inviting people to join a wellness program can help those with metabolic syndrome get better support for weight management and diabetes prevention.

  Recruiting Massachusetts Institute of Technology · Secaucus, New Jersey · NCT06725511

• HAPA-based health behavior program for adults with metabolic syndrome and chronic kidney disease

  A two-arm study will test a theory-based behavior-change program to see if it improves waist size, kidney function, and related health behaviors in adults with metabolic syndrome and chronic kidney disease.

  Recruiting Chinese University of Hong Kong · Chengdu, Sichuan · NCT06715735

• Integrated Traditional Chinese Medicine Program for Metabolic Syndrome

  This study is testing a combined approach of Chinese herbal medicine and laser acupuncture to see if it can help people with metabolic syndrome improve their health over six months.

  Recruiting Phase 1/2 Chang Gung Memorial Hospital · Taoyuan · NCT06703788

• Investigating body fat distribution and its impact on metabolic diseases in Japanese adults

  This study looks at how the way body fat is distributed affects the risk of metabolic and heart diseases in Japanese adults.

  Recruiting Osaka Metropolitan University · Sakai, Osaka · NCT06694012

• Effects of Lactate on Nutrient Absorption in Pre-Diabetes

  This study is testing if taking lactate can help people with pre-diabetes absorb nutrients better and manage fat after meals.

  Recruiting University of Aarhus · Aarhus · NCT06668714

• Effect of a nutritional supplement on women with Polycystic Ovary Syndrome

  This study is testing whether a nutritional supplement can help women with Polycystic Ovary Syndrome feel better and improve their health.

  Recruiting Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · Valencia, Valencia · NCT06551285

• Health behavior change plan for adults with metabolic syndrome and kidney disease

  A 40-person study will test a theory-based behavior-change program to see if it can reduce waist size and protect kidney function over three months in Chinese adults with metabolic syndrome and chronic kidney disease.

  Recruiting Chinese University of Hong Kong · Chengdu, Sichuan · NCT06527768

• MetAGE: deep phenotyping of how metabolism affects aging and disease

  This project will test blood-based aging biomarkers in adults of different ages and weights to see if metabolic differences relate to aging and cardiometabolic disease.

  Recruiting at 2 sites Medical University of Vienna · Vienna, State of Vienna and 1 other locations · NCT06511297

• Survey to determine eligibility for cardiovascular and obesity clinical trials

  This study is trying to see if people with heart issues or obesity can join new clinical trials by having them fill out a survey and undergo some health checks.

  Recruiting Brooklyn Clinical Research · Brooklyn, New York · NCT06412536

• Effect of weight loss methods on lifespan in metabolic syndrome patients

  This study is testing different weight loss methods to see how they affect the health and lifespan of adults with metabolic syndrome, type 2 diabetes, and high blood pressure.

  Recruiting Phase 4 University Medical Center, Kazakhstan · Astana, Astana · NCT06410352

• Investigating Choroid Plexus Dysfunction in Neurological Diseases

  This study is testing how problems with a part of the brain called the choroid plexus might be causing a rare neurological condition called LHIPFOLD in some patients and looking for possible treatments.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT06403189

• Effects of changing physical activity levels on health in middle-aged adults

  This study tests how changing physical activity levels—either cutting back or increasing exercise—affects health in middle-aged adults, especially looking at issues like metabolic syndrome and cognitive decline.

  Recruiting University of Nottingham · Nottingham, Notts · NCT06377254

• Understanding the human metagenome's role in metabolic diseases

  This study is trying to see how the bacteria and substances in our bodies relate to health and conditions like obesity and muscle loss by looking at samples from different people.

  Recruiting Sengkang General Hospital · Singapore · NCT06363253

• Assessing muscle metabolism and insulin resistance in dialysis patients through exercise

  This study is testing how exercise affects muscle metabolism and insulin resistance in dialysis patients compared to those with metabolic syndrome and healthy people to help improve treatment strategies.

  Recruiting at 2 sites University Hospital, Montpellier · Montpellier and 1 other locations · NCT06360302

• Lifestyle changes for managing metabolic syndrome

  This study is testing whether a new lifestyle program that includes intermittent fasting, exercise, and diet changes can help people with metabolic syndrome improve their health compared to those who stick to their usual habits.

  Recruiting National Health Research Institutes, Taiwan · Zhunan, Miaoli County · NCT06271200

• Understanding genetic factors that affect weight loss after bariatric surgery

  This study is trying to find out if certain genes can help predict how well people with severe obesity will lose weight after having bariatric surgery.

  Recruiting Institut de Recerca Biomèdica de Lleida · Lleida, Leida · NCT06226194

• Investigating immune and metabolic factors in early cardiovascular disease

  This study is testing if using digital wearables and AI-driven lifestyle changes can help people with early cardiovascular disease improve their heart health.

  Recruiting National University Hospital, Singapore · Singapore · NCT06211868

• Effects of Cetoleic Acid on Atherosclerosis

  This study is testing if taking cetoleic acid-rich oil can help improve heart health and lower risks for people with metabolic syndrome.

  Recruiting Oslo University Hospital · Oslo · NCT06172335

• Evaluating the effects of AM3 and probiotics on metabolic syndrome

  This study is testing whether a nutritional supplement with AM3 and probiotics can improve health markers and quality of life for adults with metabolic syndrome.

  Recruiting at 2 sites Industrial Farmacéutica Cantabria, S.A. · Madrid and 1 other locations · NCT06158152

• Effects of GLP-1 Agonists After Bariatric Surgery

  This study is testing whether continuing or stopping a specific diabetes medication after weight loss surgery helps improve health for people who have had gastric bypass or sleeve gastrectomy.

  Recruiting Phase 4 University of Missouri-Columbia · Columbia, Missouri · NCT06132477

• Comparing two care strategies for preventing cardiovascular events in at-risk patients

  This study tests if a new care strategy based on a detailed look at coronary artery disease can better prevent heart problems in people at risk but without symptoms, compared to the usual approach.

  Recruiting at 122 sites Cleerly, Inc. · Chandler, Arizona and 124 other locations · NCT06112418

• Combination therapy for cognitive impairment and metabolic syndrome

  This study is testing a new treatment using a nasal insulin spray and a diabetes medication to see if it can help older adults with mild cognitive impairment and metabolic syndrome improve their thinking and overall health.

  Recruiting Phase 2 Rutgers, The State University of New Jersey · Ramat Gan · NCT06072963

• Lifestyle medicine program to help rural adults with multiple chronic conditions

  This program will try supervised exercise and lifestyle coaching for rural adults aged 18–64 who have two or more chronic conditions to see if access to a wellness facility improves their health.

  Recruiting West Virginia School of Osteopathic Medicine · Lewisburg, West Virginia · NCT06049420

• Effects of a diabetes medication on inflammation and heart health in obese patients

  This study tests if a diabetes medication called empagliflozin can help reduce inflammation and improve heart health in obese patients with metabolic syndrome.

  Recruiting Phase 1/2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05972564

• Investigating fasting insulin and insulin resistance across different demographics

  This study looks at how fasting insulin levels and insulin resistance vary among different groups of people based on age, sex, race, weight, and conditions like PCOS to better understand metabolic health.

  Recruiting Lilli Health · Houston, Texas · NCT05950282

• Reducing blood pressure through air pollution intervention in Qatar

  This study is testing whether using portable air cleaners at home can help people with metabolic syndrome in Qatar lower their blood pressure by reducing air pollution exposure.

  Recruiting Weill Cornell Medical College in Qatar · Doha · NCT05903950

• App plus smart body fat scale program to help overweight people with schizophrenia or bipolar disorder lose weight

  See if using the Huawei Health app together with a smart body fat scale helps overweight people with schizophrenia or bipolar disorder lose weight and stay involved in their care.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT05866107

• Aggressive cholesterol-lowering treatment for asymptomatic patients with coronary calcification

  This study is testing whether a strong cholesterol-lowering treatment can help people over 40 with heart calcification avoid heart problems, even if they don't have any symptoms.

  Recruiting Phase 4 Samsung Medical Center · Seoul · NCT05845424

• Effects of weight loss with and without exercise on metabolic health

  This study is testing whether losing weight with exercise helps improve metabolic health more than just losing weight through dieting alone for people with obesity.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05806801

• Raising gut Akkermansia muciniphila with oral acetate (apple cider vinegar) during androgen deprivation therapy

  This tests whether taking oral acetate (apple cider vinegar) can raise Akkermansia muciniphila levels in the gut and help metabolic and bone health in men starting androgen deprivation therapy for metastatic castration‑sensitive prostate cancer.

  Recruiting Early Phase 1 Western University · London, Ontario · NCT05802121

• Characterizing patients treated at internal medicine clinics

  This study looks at patients with serious health issues treated in internal medicine clinics to see how their different conditions affect their care and to find better ways to diagnose and treat them.

  Recruiting at 2 sites IRCCS San Raffaele · Milan and 1 other locations · NCT05780099

• ANKASCIN 568-P red yeast rice for lowering HbA1c and blood sugar

  This study will test whether taking ANKASCIN 568-P red yeast rice capsules daily can lower HbA1c and help control blood sugar in adults with high blood sugar or metabolic syndrome.

  Recruiting SunWay Biotech Co., LTD. · Taipei · NCT05737342

• Using blood samples to identify heart failure risks in diabetes patients

  This study is trying to see if blood tests can help find out which people with type 2 diabetes are at risk for heart failure.

  Recruiting Hospices Civils de Lyon · Bron · NCT05651919

• Screening patients at risk for liver disease in Europe

  This study is trying to find out if screening high-risk patients in Europe for liver disease using simple tests can help doctors identify and better understand conditions like metabolic dysfunction-associated steatotic liver disease.

  Recruiting at 6 sites Julius Clinical · Brussels, Vlaams-brabant and 12 other locations · NCT05651724

• Using sit-stand desks to improve health in sedentary workers

  This study is testing if using sit-stand desks can help people with prediabetes, obesity, and metabolic syndrome who have desk jobs improve their health.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05585190

• Using a new form of Tacrolimus after liver transplantation

  This study is testing a new version of a medication called Envarsus to see if it can help liver transplant patients avoid side effects while still keeping their immune system in check.

  Recruiting Phase 4 University of Alberta · Edmonton, Alberta · NCT05242315

• Time-restricted eating for postmenopausal women with metabolic issues

  This study is testing if eating all meals within a 10-hour window can improve metabolic health in postmenopausal women who have metabolic issues.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT04893226

• Effects of exercise on fat tissue in obese individuals

  This study tests how exercise affects fat tissue in people with obesity to see if it can help improve their metabolism and manage weight better.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT04812314

• Observational study on bariatric surgery outcomes

  This study looks at how bariatric surgery affects weight loss and related health issues like diabetes in patients over two years after their surgery.

  Recruiting Medical University of Bialystok · Bialystok, Podlaskie Voivodeship · NCT04634591

• Examining how fat tissue expands during overeating

  This study is testing how fat tissue in the body changes when people overeat for a short time to see how it affects their overall health, especially regarding obesity and metabolic issues.

  Recruiting Pennington Biomedical Research Center · Baton Rouge, Louisiana · NCT04583514

• Effects of exercise and medication on blood flow and insulin action in adults with metabolic syndrome

  This study is testing whether exercise, a diabetes medication called liraglutide, or a mix of both can improve blood flow and insulin function in adults with metabolic syndrome.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT04575844

• Registry for patients referred to cardio-oncology

  This study is collecting information from cancer patients who are referred for heart health checks to see how cancer treatments might affect their hearts.

  Recruiting European Georges Pompidou Hospital · Paris · NCT04407780

• Observational cohort for non-alcoholic fatty liver disease and related conditions

  This study is trying to learn more about non-alcoholic fatty liver disease and its related conditions by looking at patients with different stages of the disease and comparing them to people with diabetes and obesity who don't have it.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, Rome/lazio/italy · NCT04371042

• Registry for cardiometabolic risk factors

  This study is testing how different heart and metabolic health factors affect people to help prevent future heart problems.

  Recruiting Austral University, Argentina · Pilar, Buenos Aires · NCT04040777

• Effects of animal and plant proteins on glucose metabolism

  This study is testing whether eating more animal or plant proteins can help people improve their blood sugar control and overall metabolic health.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT03994367

• Understanding health trends in Puerto Rico

  This study is trying to understand health trends in Puerto Rico by looking at diet, mental health, and heart health in adults aged 30-75 over time.

  Recruiting Harvard School of Public Health (HSPH) · San Juan · NCT03794531

• Investigating nutritional and environmental factors in elderly health

  This study is trying to find out how nutrition and the environment affect the health of older people living in Nanshan to help prevent diseases like high blood pressure and diabetes.

  Recruiting Sun Yat-sen University · Shenzhen, Guangdong and 1 other locations · NCT03569735

• Effects of probiotics on gut health in people with metabolic syndrome

  This study is testing if eating yogurt with probiotics can improve gut health and reduce inflammation in people with metabolic syndrome.

  Recruiting Phase 1/2 Penn State University · University Park, Pennsylvania · NCT03418857

• Investigating the effects of obesity and metabolic syndrome on asthma and airway health

  This study is testing how obesity and metabolic syndrome affect asthma and lung health in different groups of people with and without asthma.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT03215836

• Examining how the body responds to endotoxin exposure

  This study is testing how healthy people's immune systems react to a substance called endotoxin by looking at their blood samples to see if it helps us understand links to conditions like asthma and cancer.

  Recruiting National Institutes of Health Clinical Center (CC) · Research Triangle Park, North Carolina · NCT01143480

• Exploring genetic factors of obesity in young Chinese individuals

  This study is trying to see how genetics might play a role in obesity among young people in China by comparing those who are obese with those who are not.

  Recruiting Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT01084967

NIH-funded research (newest 40 of 58)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrated biomarker study of metabolic syndrome in pregnant women with HIV on DTG-based ART

  Researchers will look for biological signs in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems happen and how these affect pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593952

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based ART

  This project looks at why some pregnant women living with HIV on a common DTG-based therapy gain weight or develop metabolic problems, by studying their proteins and metabolites across four sites in the US and Nigeria.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593951

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based therapy

  This project looks at markers in pregnant women living with HIV who are on a DTG-containing regimen to understand why some develop metabolic problems during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11572352

• Metabolic syndrome and brain support cells: how it may lead to Alzheimer’s disease

  A researcher is studying how midlife metabolic problems like diabetes and obesity may disrupt brain cells that support neurons, potentially leading to Alzheimer's disease and related dementia in later life.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11520494

• GLP-1 medicines to improve heart, kidney, and metabolic health for people with HIV and type 2 diabetes

  A real-world study will look at how GLP-1 receptor agonists affect heart and kidney health and lifetime costs for people living with HIV and type 2 diabetes.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11470780

• A new metabolic risk score to predict heart disease in Yup’ik Alaska Native adults

  A new, questions-free way to measure heart-disease risk in Yup’ik Alaska Native adults by combining everyday health clues with home-life factors.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11438029

• Liver health, metabolic syndrome, and heart disease risk in Black World Trade Center responders

  A short, patient-friendly study explores how liver-related factors and social conditions contribute to heart disease risk in non-Hispanic Black World Trade Center responders.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11387178

• Prevention of Hepatocellular Cancer Related to Metabolic Disease

  A multi-project effort to reduce deaths from liver cancer by studying people with metabolic-related liver disease and finding ways to predict risk and prevent cancer.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11379126

• Gut health and HIV: how the gut barrier and microbiome affect metabolic health in HIV-positive men who have sex with men

  A research grant is exploring how the gut bacteria and gut barrier may influence metabolic problems in HIV-positive MSM, with the goal of finding ways to reduce obesity and heart-disease risk.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11377104

• GLP-1 receptor drugs to protect lymphatic health in obesity-related swelling

  Aims to see if GLP-1R agonists can improve lymphatic vessel function and reduce swelling risk in people affected by obesity and lymphedema.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11347315

• How metabolic syndrome makes brain-infecting viruses worse

  Seeing if the cell metabolism problems tied to metabolic syndrome make brain-infecting viruses like West Nile cause more severe illness.

  NIH research University of Kentucky · Lexington, United States · NIH-11330311

• Airborne PCBs and their effects on fat tissue and metabolism

  The team is seeing if breathing PCB-contaminated air—like levels found in some schools—can harm fat tissue and raise the risk of metabolic problems, especially when exposure happens early in life.

  NIH research University of Iowa · Iowa City, United States · NIH-11326740

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on a DTG-based regimen

  Researchers will study blood and metabolite markers in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems may occur during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11325705

• How the CELA2A enzyme affects insulin, weight, and heart disease risk

  This work looks at how changes in the CELA2A enzyme affect insulin function and the risk of type 2 diabetes and early heart disease in people.

  NIH research Yale University · New Haven, United States · NIH-11319809

• Genetic factors linked to heart, kidney, and diabetes risks in NHPI people

  A research project looks for genetic clues that connect heart, kidney, and diabetes risks in Native Hawaiians and Pacific Islanders to improve understanding and care.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11319639

• Time‑restricted eating to improve blood sugar and heart health in adults with metabolic syndrome

  This trial tests whether limiting daily eating to a 10-hour window (about a 14-hour overnight fast) helps adults with metabolic syndrome improve blood sugar control, weight, and heart‑health markers.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11314554

• Protecting tissue (bioprosthetic) heart valves in people with metabolic syndrome

  This project tries a special polymer coating to help tissue heart valves last longer in people with metabolic syndrome or type 2 diabetes.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11296840

• TRPV4's role in lymphatic vessels and metabolic syndrome

  Researchers are looking at whether changing activity of a protein called TRPV4 can help lymphatic vessels pump better and reduce complications in people with obesity and metabolic syndrome.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11293397

• GLO1 and how it affects obesity, type 2 diabetes, and fatty liver disease

  This project tests whether changing the enzyme GLO1 can protect adults who have or are at risk for obesity, type 2 diabetes, and fatty liver disease.

  NIH research University of Arizona · Tucson, United States · NIH-11290384

• How a brain receptor called MC4R may cause antipsychotic-related weight gain and diabetes

  Researchers are looking at whether changes to a brain receptor called MC4R explain why people taking antipsychotic medications often gain weight and develop diabetes.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11289426

• How metabolic syndrome affects the severity of brain infections caused by viruses.

  This study is looking at how metabolic syndrome might make viral infections that affect the brain, like West Nile Virus, worse, and it’s for anyone interested in understanding why people with this condition may have tougher battles with these infections.

  NIH research University of Kentucky · Lexington, United States · NIH-11289064

• How TGDS gene changes lead to Catel-Manzke and Pierre Robin facial differences

  Researchers will use gene-editing in mice to learn how mutations in the TGDS gene cause Catel-Manzke syndrome and Pierre Robin facial differences.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11270837

• How inhaled nanoparticles worsen inflammation in people with metabolic syndrome

  This project looks at how breathing tiny airborne particles affects inflammation and its natural resolution in people with metabolic syndrome.

  NIH research Purdue University · West Lafayette, United States · NIH-11254906

• How metabolism and chronic inflammation contribute to gout

  This project uses genetic and blood-based measurements from adults to understand why some people with high uric acid develop gout and how metabolic syndrome and long-term inflammation play a role.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11251315

• Investigating how traffic-related air pollution may worsen metabolic disorders.

  This study is looking at how air pollution from busy roads might affect our bodies and lead to problems like obesity and diabetes, using rats to see how it impacts their health over time.

  NIH research University of California at Davis · Davis, United States · NIH-11241194

• Investigating the links between metabolic syndrome, chronic inflammation, and gout

  This study is looking at how gout, a painful type of arthritis, is related to metabolic syndrome, which includes issues like insulin resistance, to help patients understand their condition better and find new ways to treat it.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11239944

• How insulin resistance and metabolic syndrome may damage the brain

  Researchers are using a primate model to study how insulin resistance and metabolic syndrome can cause brain inflammation and Alzheimer-like changes in adults with type 2 diabetes risk factors.

  NIH research University of California at Davis · Davis, United States · NIH-11237585

• Understanding metabolic syndrome in pregnant women with HIV on specific treatments

  This study is looking at how a specific HIV treatment called Dolutegravir affects weight gain and overall health in pregnant women with HIV, to help understand any health challenges they might face during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11161556

• Stopping Liver Cancer Linked to Metabolic Syndrome

  This work aims to find better ways to prevent liver cancer in people who have fatty liver disease caused by metabolic issues.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11146333

• Understanding how stress affects diet and health in people facing food insecurity

  This project explores how stress, specifically the hormone cortisol, might worsen the health effects of food insecurity, such as obesity and diabetes.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11131073

• How metabolic syndrome harms heart blood vessels

  The team is testing whether common diabetes drugs can help blood vessels grow and protect the heart in people with metabolic syndrome and diabetes by studying a pig model that mimics patients.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11097242

• Peptide medicines to help weight loss and control blood sugar in type 2 diabetes

  Developing new peptide drugs to help adults with type 2 diabetes and obesity lose weight and improve blood sugar control.

  NIH research Velum, INC. · Cambridge, United States · NIH-11094854

• Understanding gut health and metabolic syndrome in HIV-positive men

  This work explores how gut bacteria and intestinal health might contribute to metabolic syndrome in men living with HIV who have sex with men.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11092260

• Understanding the genetic causes of a craniofacial metabolic syndrome

  This study is looking into the genetic causes of Catel-Manzke syndrome, which affects how the face develops, by creating mouse models to better understand how these genetic changes happen and what they mean for growth and health.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11069936

• Investigating a new gene linked to metabolic syndrome and diabetes

  This study is looking at a gene called CELA2A to see how changes in it might affect insulin resistance and related health problems, with the hope of finding better treatments for people with type 2 diabetes and metabolic syndrome.

  NIH research Yale University · New Haven, United States · NIH-11059201

• Effects of timed eating on blood sugar and cell function in people with metabolic syndrome

  This study is looking at how eating within certain hours of the day can affect blood sugar levels and energy production in people with metabolic syndrome, and it aims to find out if this eating schedule can help improve their health.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11058313

• Improving heart valve durability for patients with metabolic syndrome

  This study is looking at how metabolic syndrome affects the lifespan of heart valves used in surgeries, and it aims to find ways to make these valves last longer for patients with this condition by testing a new material.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11051155

• Understanding how glyoxalase 1 affects obesity and diabetes

  This study is looking at how a protein called GLO1 affects weight gain, blood sugar levels, and liver health in mice, which could help us find new ways to treat obesity, Type 2 diabetes, and fatty liver disease.

  NIH research University of Arizona · Tucson, United States · NIH-11049142

• Understanding how glucose transport is regulated in metabolic syndrome

  This study looks at how insulin helps your body use sugar by focusing on a special protein that helps move sugar transporters to where they’re needed in your cells, and it aims to find out what goes wrong in people with insulin resistance, which could lead to better treatments for type 2 diabetes.

  NIH research Yale University · New Haven, United States · NIH-11039963

• Understanding metabolic syndrome in tuberculosis patients in Tanzania

  This study is looking at how tuberculosis (TB) affects people’s metabolism, especially those who are newly diagnosed with TB and have pre-diabetes, to see how their health changes during treatment and what that means for their overall well-being.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11033690

Related topics

Quick answers

How many Metabolic Syndrome clinical trials are recruiting right now?

113, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 37 countries. The most sites are in United States (33 trials), China (11 trials), Egypt (8 trials), Taiwan (7 trials), Spain (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 7, Phase 2: 4, Phase 1/2: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →