Kodo Millet Porridge and Gut Health in Overweight and Obese Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, open-label interventional study enrolls 50 adults with BMI ≥ 25 kg/m² to consume 200 ml of Kodo millet porridge daily for 12 weeks. Researchers will compare gut microbiota composition using 16S sequencing and measure circulating short-chain fatty acids, glucose and lipid levels, insulin resistance, antioxidant capacity, and inflammatory and oxidative stress markers before and after the intervention. The goal is to see if the millet porridge modulates the gut ecosystem and metabolic parameters associated with obesity and metabolic syndrome. Participants will maintain their usual diet and physical activity levels during the study. The study excludes individuals with certain chronic diseases, recent antibiotic use, and other factors that could confound results.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Adults aged 20-60 years.
* Willingness to provide informed consent.
* Willingness to consume Kodo millet porridge daily for 12 weeks.
* No planned changes in diet or physical activity during the study.
* Overweight or obese (BMI ≥ 25 kg/m²), placing them at risk for metabolic disorders.

Exclusion Criteria

* Known allergies to millet or any porridge ingredients.
* Individuals who are taking on-counter dietary fiber and probiotics supplements
* History of any chronic gastrointestinal diseases (e.g., IBD, gastritis, irritable bowel syndrome).
* Pregnant or lactating women.
* Antibiotic use in last 3 months.
* Alcohol abuse, more than 2 drink per day
* Presence and usage of medications for any serious chronic illnesses, including uncontrolled diabetes (HbA1c \> 9), cardiovascular disease (aldosterone antagonists, alpha blockers, alpha-beta blockers, anticoagulants, antiplatelets, angiotensin-converting enzyme inhibitors, angiotensin 2 receptor blockers, beta blockers, calcium channel blockers, diuretics, digoxin) , renal disease, neurological or mental disorders, coagulation disorders, and cancer.

Where it's running

• JSS Medical College, JSS Academy of Higher Education & Research(JSSAHER).
  Mysore, Karnataka, India Recruiting

Study contacts

• Principal investigator: Prerana Shridhar Bhat, MSc — Jss Mc,jss Aher
• Study coordinator: Prerana Shridhar Bhat, MSc
• Email: preranabhat@jssuni.edu.in
• Phone: +918762399079

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.