Reducing blood pressure through air pollution intervention in Qatar

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of in-home portable air cleaners in reducing PM2.5 exposure and improving systolic blood pressure in patients with metabolic syndrome living in Qatar. Over a four-week period, participants will use air cleaners with and without HEPA filters to assess their impact on cardiovascular health. The study addresses the significant role of air pollution in chronic cardio-metabolic diseases, particularly hypertension. By measuring changes in blood pressure and biochemical parameters, the research seeks to provide insights into the durability of these interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 and less than 65 years old
* Living in a single residence (home, apartment) located anywhere in Qatar
* Mild systolic hypertension: screening visit systolic BP 130 to 159 mm Hg (off treatment or taking ≤ 2 BP medications that have been stable without changes during prior one week)
* Either:

Type 2 diabetes patients (HbA1c \> 6.5%) OR Non-type 2 diabetes patients with two or more additional criteria for the metabolic syndrome,

* Waist circumference ≥102 cm if male and ≥88 cm if female
* Fasting triglycerides ≥150 mg/dL (or taking a triglyceride-lowering medication)
* HDL-C ≤ 40 mg/dL if male and ≤ 50 mg/dL if female (or taking an HDL-raising medication),
* Fasting glucose ≥100 mg/dL (or taking an antidiabetic medication)

Exclusion Criteria:

* Pregnancy (self-reported)
* ≥stage 4 kidney disease (estimated glomerular filtration rate \<30 ml/min).
* A medical condition placing the participant at risk from participation (per investigators)
* Expected overnight travel outside their residence during the study
* HEPA filter within the ACs of the residence (self-reported) or individual use of HEPA filter filter
* Unable to comprehend/sign an informed consent
* Lung disease requiring oxygen
* Cancer receiving treatment.
* Type 1 diabetes or MODY diabetes
* Screening visit: BP ≥160/100 mm Hg
* Medication changes in the past week. If participants are on medications for high BP or hyperlipidemia, they will need to have had stable therapy for at least one week with no planned changes during the study
* Left upper arm circumference \>17 inches as this will make BP levels inaccurate with the home monitor used
* Acute illness or infectious symptoms within the prior 4 weeks.

Where it's running

• Hamad Medical Corporation
  Doha, Qatar Recruiting

Study contacts

• Principal investigator: Charbel Abi Khalil, MD — Weill Cornell Medical College in Qatar
• Study coordinator: Charbel Abi Khalil, MD
• Email: cha2022@qatar-med.cornell.edu
• Phone: +974 4492 8484

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Fulvic acid supplements for metabolic syndrome

  This study tests whether 50 mg or 100 mg of fulvic acid daily for 12 weeks can help people with metabolic syndrome or prediabetes.

  Recruiting Arizona State University · Phoenix, Arizona · NCT07927283

• Asprosin and miRNA Profiles in Young Women with Metabolic Syndrome

  This study tests whether certain blood biomarkers, including asprosin and six microRNAs, differ between young women with metabolic syndrome and healthy peers.

  Recruiting University of Applied Sciences in Nowy Targ · Nowy Targ, Lesser Poland Voivodeship · NCT07917364

• Using Multimodal Ultrasound to Check Muscle Mass in Metabolic Disease Patients

  This study tests whether a multimodal ultrasound approach can accurately measure muscle mass in people with metabolic syndrome, obesity, sarcopenia, or type 2 diabetes.

  Recruiting Zhangzhou Municipal Hospital · Zhangzhou, Fujian · NCT07836088

• Low-Calorie Diet in adolescents with Familial Mediterranean Fever and metabolic syndrome

  A group of adolescents with both FMF and metabolic syndrome will try a low-calorie diet for 3 months to see if it helps manage metabolic symptoms.

  Recruiting Cairo University · Giza, Dokki · NCT07833007

• Exercise for Metabolic Syndrome and Fatty Liver in Adolescent Girls with Celiac Disease

  This study tests whether a 3-month walking program helps improve metabolic syndrome and fatty liver in adolescent females with celiac disease.

  Recruiting Cairo University · Giza, Dokki · NCT07832994

• Longevity Metrics AI/ML Development Study

  Researchers are testing AI models that score health screening tests and predict outcomes like life expectancy for adults, using ongoing follow-up data.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07808619

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.