How moderate wine drinking affects healthy aging through post-meal extracellular vesicles

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy adult participants will consume a single serving of red wine, white wine, or water while blood samples are taken before and after consumption to capture postprandial changes. Researchers will profile the EVs' lipidome and proteome and analyze their cargo and concentration. Functional assays will test how these EVs interact with vascular, immune, and brain-related cells, including potential effects on blood-brain barrier and microglia-relevant pathways. The goal is to link acute wine-induced EV changes to mechanisms relevant for cardiovascular and brain health.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Healthy adult men and women aged 35 to 65 years.
* Body Mass Index (BMI) between 18.5 and 29.9 kg/m².
* Non-smokers or ex-smokers for at least 12 months.
* Moderate alcohol consumers, defined as ≤2 units/day for men and ≤1 unit/day for women.
* Normal fasting glucose and lipid profile at screening.
* Willing and able to refrain from alcohol, polyphenol-rich foods, and intense exercise for 48 hours before each study visit.
* Able to understand the study procedures and provide written informed consent.

Exclusion Criteria

* History or clinical evidence of cardiovascular, hepatic, renal, thyroid, gastrointestinal, or metabolic diseases (including diabetes, dyslipidemia, or hypertension).
* Use of medications or supplements known to affect glucose, lipid, or inflammatory metabolism (e.g., statins, corticosteroids, anti-inflammatory drugs).
* Pregnancy or breastfeeding.
* Recent blood donation (within the last 3 months) or planned blood donation during the study period.
* Major weight change (\>5% of body weight) within the last 3 months.
* Participation in another clinical or biomedical study within the previous 3 months.
* Known allergy or intolerance to wine, alcohol, or its components (e.g., sulfites).
* History of alcohol abuse or inability to abstain from alcohol outside the study context.
* Reluctance to receive information about incidental health findings arising from the study.
* Any condition judged by the investigators to limit compliance or increase study risk (e.g., psychiatric disorders, inability to adhere to fasting requirements).

Where it's running

• Av. de Sánchez Pizjuán, s/n, 41009 Sevilla Facultad de Medicina . Universidad de Sevilla
  Seville, Sevilla, Spain Recruiting

Study contacts

• Study coordinator: Sergio Montserrat-de la Paz, Full Professor
• Email: delapaz@us.es
• Phone: +34 605383541

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.