How moderate wine drinking affects healthy aging through post-meal extracellular vesicles
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles
NA · University of Seville · NCT07361887
This test will see if a single serving of red or white wine changes circulating extracellular vesicles in healthy adults aged 35–65.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 8 (estimated) |
| Ages | 35 Years to 36 Years |
| Sex | All |
| Sponsor | University of Seville (other) |
| Locations | 1 site (Seville, Sevilla) |
| Trial ID | NCT07361887 on ClinicalTrials.gov |
What this trial studies
Healthy adult participants will consume a single serving of red wine, white wine, or water while blood samples are taken before and after consumption to capture postprandial changes. Researchers will profile the EVs' lipidome and proteome and analyze their cargo and concentration. Functional assays will test how these EVs interact with vascular, immune, and brain-related cells, including potential effects on blood-brain barrier and microglia-relevant pathways. The goal is to link acute wine-induced EV changes to mechanisms relevant for cardiovascular and brain health.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 35–65 with BMI 18.5–29.9, non-smokers or ex-smokers for ≥12 months, moderate alcohol consumers, normal fasting glucose and lipids, and willing to follow pre-visit restrictions.
Not a fit: People with existing cardiovascular, metabolic, hepatic, renal, thyroid, or inflammatory diseases, those taking medications that alter metabolism, pregnant or breastfeeding individuals, smokers, or those outside the age/BMI ranges are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could clarify a biological mechanism by which moderate wine intake influences cardiovascular and brain health and guide dietary recommendations or EV-based therapies.
How similar studies have performed: While epidemiologic and mechanistic work supports moderate wine or polyphenol benefits for cardiovascular risk, using postprandial extracellular vesicle profiling to explain those effects is novel and largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Healthy adult men and women aged 35 to 65 years. * Body Mass Index (BMI) between 18.5 and 29.9 kg/m². * Non-smokers or ex-smokers for at least 12 months. * Moderate alcohol consumers, defined as ≤2 units/day for men and ≤1 unit/day for women. * Normal fasting glucose and lipid profile at screening. * Willing and able to refrain from alcohol, polyphenol-rich foods, and intense exercise for 48 hours before each study visit. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria * History or clinical evidence of cardiovascular, hepatic, renal, thyroid, gastrointestinal, or metabolic diseases (including diabetes, dyslipidemia, or hypertension). * Use of medications or supplements known to affect glucose, lipid, or inflammatory metabolism (e.g., statins, corticosteroids, anti-inflammatory drugs). * Pregnancy or breastfeeding. * Recent blood donation (within the last 3 months) or planned blood donation during the study period. * Major weight change (\>5% of body weight) within the last 3 months. * Participation in another clinical or biomedical study within the previous 3 months. * Known allergy or intolerance to wine, alcohol, or its components (e.g., sulfites). * History of alcohol abuse or inability to abstain from alcohol outside the study context. * Reluctance to receive information about incidental health findings arising from the study. * Any condition judged by the investigators to limit compliance or increase study risk (e.g., psychiatric disorders, inability to adhere to fasting requirements).
Where this trial is running
Seville, Sevilla
- Av. de Sánchez Pizjuán, s/n, 41009 Sevilla Facultad de Medicina . Universidad de Sevilla — Seville, Sevilla, Spain (RECRUITING)
Study contacts
- Study coordinator: Sergio Montserrat-de la Paz, Full Professor
- Email: delapaz@us.es
- Phone: +34 605383541
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Atherosclerosis Cardiovascular Disease, Obesity, Metabolic Syndrome, Metabolic Disorders, Inflammation, Neurodegeneration, Neurodegenerative Disease, Alzheimer s Disease