Neonatal BNP and metabolic syndrome risk in adolescents
Official title: Exploring B-Type Natriuretic Peptide (BNP) Evolution, From the Neonatal to Adolescent Period, as a Tool to Early Identify the Risk for Metabolic Syndrome (MetS) in a Former Preterm and Full Term Adolescent Population
Run by Fondazione IRCCS Policlinico San Matteo di Pavia · NCT07181733 · Data updated 2026-11-12
This project will see if newborn BNP levels and early heart ultrasound measurements are linked to metabolic syndrome in adolescents who had those tests as infants.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 13 Years to 18 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, pavia) |
| Status | Recruiting |
| Started | May 8, 2024 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | September 18, 2025 |
| Trial ID | NCT07181733 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adolescents born in 2009-2011 who have documented BNP levels and echocardiography performed during the first month of life and available records at the Pavia pediatric cardiology unit.
✕Probably not a fit
Patients without documented neonatal BNP or echocardiographic data, or those outside the adolescent age cohort, are unlikely to benefit from this specific analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective observational analysis of adolescents born in 2009-2011 who had BNP concentrations and echocardiographic parameters measured during their first month of life. Researchers will identify which participants meet pediatric metabolic syndrome criteria (using commonly cited definitions such as Cook, Zimmet, and de Ferranti) and compare early-life BNP and echo findings between those with and without metabolic syndrome. The study uses clinical record review and statistical analysis (including factor or risk-score approaches) to look for associations between neonatal cardiac biomarkers/measurements and later metabolic risk. There are no interventions; the goal is to identify potential early-life markers of cardiometabolic risk.
Why it matters
Potential benefit: If successful, neonatal BNP or early echo findings could help identify children at higher risk for metabolic syndrome so earlier prevention or monitoring can be offered.
How similar studies have gone: While adult studies have linked natriuretic peptides to metabolic traits, longitudinal pediatric evidence is limited and this application in adolescents is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adolescents whose BNP concentration and echocardiographic parameters analysed during their first month of life (2009-11)
Where it's running
-
U.O.S. Cardiologia Pediatrica
Pavia, pavia, Italy Recruiting
Study contacts
- Study coordinator: Alessia C.A. Codazzi, MD
- Email: a.codazzi@smatteo.pv.it
- Phone: +390382502915
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.