Time-restricted eating for postmenopausal women with metabolic issues
Official title: Circadian Rhythms in Postmenopausal Women
Run by University of Kentucky · NCT04893226 · Data updated 2026-11-12
This study is testing if eating all meals within a 10-hour window can improve metabolic health in postmenopausal women who have metabolic issues.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 65 Years |
| Sex | Women only |
| Enrollment | 164 (estimated) |
| Sponsor | University of Kentucky Academic / other |
| Locations | 1 site (Lexington, Kentucky) |
| Status | Recruiting |
| Started | October 19, 2021 |
| Main results expected | January 31, 2027 |
| Study ends | January 31, 2027 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT04893226 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are postmenopausal women aged 45-65 who are prediabetic or exhibit at least two features of metabolic syndrome.
✕Probably not a fit
Patients with diabetes, significant heart disease, or those on hormone therapy are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of time-restricted feeding (TRF) on metabolic health in postmenopausal women who are metabolically unhealthy. Participants will be randomly assigned to either a TRF group, where they will consume all their daily calories within a 10-hour window, or a control group with no dietary restrictions. The study will last for 18 weeks, during which various metabolic parameters, including insulin sensitivity and body composition, will be measured. Data collection will include baseline assessments followed by monitoring of eating patterns and metabolic changes throughout the intervention period.
Why it matters
Potential benefit: If successful, this intervention could improve metabolic health and reduce the risk of conditions like diabetes and heart disease in postmenopausal women.
How similar studies have gone: Previous studies on time-restricted feeding have shown promising results in improving metabolic health, suggesting that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * postmenopausal women * age 45-65 years * prediabetic or have at least 2 features of metabolic syndrome Exclusion Criteria: * on hormone therapy * diabetes * heart disease * alcohol consumption of \>2 drinks per day * significant circadian disruption * having care-taking responsibilities that significantly affect sleep * shift work or irregular lifestyle * uncontrolled sleep apnea or other uncontrolled sleep disorder * extreme early or late chronotypes * significant psychiatric disorders * taking ADHD medications * diagnosed dysregulated eating behaviors * smoking \>5 cigarettes/day or 30 pack-year history * participating in formal weight loss program * not weight stable
Where it's running
-
University of Kentucky
Lexington, Kentucky, United States Recruiting
Study contacts
- Principal investigator: Julie S Pendergast, PhD — University of Kentucky
- Study coordinator: Matt Thomas, PhD
- Email: jmthomg@uky.edu
- Phone: (859) 218-6770
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.