Condition

Prediabetes clinical trials and research

• 88Clinical trials
• 43NIH research projects
• 1New in 30 days
• 21Countries

Newest Prediabetes clinical trials

All recruiting trials (88)

• Lifestyle Metabotype Study B: Understanding Personalized Glucose Responses

  This study tests how lifestyle, metabolism, and brain energy use relate to each person’s blood sugar response after meals, across people with and without prediabetes or type 2 diabetes.

  Recruiting at 2 sites German Institute of Human Nutrition · Berlin and 1 other locations · NCT07888257

• Lifestyle Metabotype Study: How Daily Habits Shape Blood Sugar

  This observational study tests whether personal lifestyle and biological factors can predict how a person’s blood sugar responds after meals.

  Recruiting German Institute of Human Nutrition · Potsdam, Potsdam-Rehbrücke · NCT07868601

• Hourly stair-climbing snacks to improve blood sugar and heart health in adults with prediabetes

  This study tests whether short stair-climbing bursts every hour can improve blood sugar and vascular health in adults with prediabetes.

  Recruiting St. Louis University · St Louis, Missouri · NCT07847684

• Smart probiotic and nutraceutical approach for cardiometabolic health in older adults

  This trial tests whether a probiotic-containing nutraceutical strategy can improve metabolic health and blood pressure in adults over 65 with prediabetes or cardiovascular disease.

  Recruiting Azienda Ospedaliero Universitaria Maggiore della Carita · Novara · NCT07817290

• Family-based diabetes prevention for parents and kids

  A family-focused program tests whether a 12-week lifestyle plan can help parents at risk for diabetes lose weight and improve healthy habits for themselves and their children aged 12–17.

  Recruiting Morehouse School of Medicine · Atlanta, Georgia · NCT07808723

• Cardiorespiratory and muscular fitness in children with obesity and autism

  This study tests whether cardiorespiratory fitness and handgrip strength differ between children with obesity who have autism and those who do not, and how these fitness measures relate to body size, composition, and cardiometabolic health.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07804680

• Health for Hungary: Long-term blood and health data collection to study aging and disease onset

  This study tests whether routine blood tests plus advanced molecular analyses can help detect the early stages of non-communicable diseases in adults over 40.

  Recruiting at 21 sites Center for Molecular Fingerprinting Research Nonprofit LLC · Balatonfüred and 32 other locations · NCT07743021

• High-Intensity Interval Training vs. Continuous Endurance Training in Prediabetes

  This study tests whether short bursts of intense exercise or steady, longer workouts can improve blood sugar control and fitness in people with prediabetes.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07713030

• Community Dining, Walking, and Glucose in Older Adults

  This study tests whether eating lunch and dinner at a subsidized community dining site affects post-meal walking and glucose patterns in older adults with prediabetes.

  Recruiting Hunan Normal University · Changsha, Hunan · NCT07695675

• Personality Traits and Biochemical Risk Markers in Routine Health Assessments

  This study tests whether personality traits relate to the number of abnormal lab results found during a standard health checkup in adults.

  Recruiting Medical Center TOPMED · Târgu Mureş, Mureș County · NCT07653048

• Avocado Diet Study for Prediabetes and Insulin Resistance

  This study tests whether eating an avocado-rich meal plan for four weeks can improve triglyceride and glucose metabolism in adults with prediabetes and insulin resistance.

  Recruiting Clinical Nutrition Research Center, Illinois Institute of Technology · Chicago, Illinois · NCT07624500

• Risk-informed shared-decision making to help people with prediabetes prevent diabetes

  This study tests whether a risk-informed shared decision-making visit or a plain patient portal message can help adults with prediabetes take steps to prevent diabetes.

  Recruiting Johns Hopkins University · Frederick, Maryland · NCT07553325

• Effects of exogenous ketones on brain energy and thinking in older adults with prediabetes

  In older adults with prediabetes, researchers will test if a single dose of a ketone supplement can boost brain energy use and processing speed compared with people with normal blood sugar.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT07546409

• Using Native Hawaiian cultural values to strengthen youth resilience, health, and well-being

  This project will try a community referral program that connects Native Hawaiian and Pacific Islander youth ages 12–25 to culture-based Kaiona programs to see if it improves mental health and chronic conditions like asthma and obesity.

  Recruiting Waianae Coast Comprehensive Health Center · Waianae, Hawaii · NCT07536256

• Pharmacist-led continuous glucose monitoring for people with prediabetes

  Pharmacists will try continuous glucose monitoring to see if it improves blood sugar and health habits in adults with prediabetes.

  Recruiting at 2 sites University of South Florida · Tampa, Florida and 1 other locations · NCT07529366

• Basic carbohydrate counting for adults with prediabetes

  This program will test whether basic carbohydrate counting education helps adults with prediabetes lower their HbA1c.

  Recruiting Marmara University · Istanbul, Pendik · NCT07525622

• MOTS-c to improve insulin sensitivity in adults with prediabetes and overweight or obesity

  This 12-week test will see if the investigational peptide MOTS-c can improve insulin sensitivity in adults with prediabetes who are overweight or have obesity.

  Recruiting Phase 2 Hudson Biotech · Shenzhen, Guangdong · NCT07505745

• High-fiber mHealth program for young adults with prediabetes

  This three-month phone-based program tests whether weekly home-delivered high-fiber foods, brief education, and continuous glucose monitor feedback can improve blood sugar control in young adults (18–39) with prediabetes.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT07491653

• A Latina-focused program to address nutrition, cravings, and eating patterns to prevent type 2 diabetes

  This program will try a culturally adapted 'Regulation of Cues' behavioral approach to help Latinas with prediabetes and obesity lose weight and lower their risk of developing type 2 diabetes.

  Recruiting University of California, San Diego · La Jolla, California · NCT07478263

• Continuous glucose monitoring plus AI video coaching for adults with prediabetes

  This project will try combining a wearable continuous glucose monitor with daily AI-generated education videos to see if it helps adults with prediabetes improve their blood sugar over 20 days.

  Recruiting University of Southern California · Los Angeles, California · NCT07477249

• Integrating a Produce Prescription into a Diabetes Prevention Program

  This study tests whether adding a prescription produce program to a diabetes prevention program helps adults with prediabetes reduce risk factors better than a standard program.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT07472712

• Vitamin D to Help Blood Sugar in People at Risk for Type 2 Diabetes

  This study tests whether weekly vitamin D, adjusted to reach a target blood level, can help control blood sugar in adults with prediabetes.

  Recruiting Phase 3 Tufts Medical Center · Boston, Massachusetts · NCT07448974

• Liquid nutritional product with carob extract to improve carbohydrate metabolism in people with prediabetes.

  This 90-day test will see if a liquid nutritional product containing carob extract can help improve blood sugar control in adults with prediabetes.

  Recruiting Universidad Católica San Antonio de Murcia · Murcia · NCT07420998

• Exercise timing for people with prediabetes and overweight/obesity

  This study tests whether doing a single exercise session in the morning or in the evening helps control blood sugar better in adults with prediabetes who are overweight or obese.

  Recruiting German Diabetes Center · Düsseldorf · NCT07389005

• Smartwatch-based program to improve heart health in adults with overweight and cardiometabolic risk

  This project will test whether a smartwatch-led exercise, diet, and coaching program can help adults who are overweight or obese with prehypertension, prediabetes, or borderline high cholesterol improve their cardiovascular health.

  Recruiting at 3 sites Beijing Anzhen Hospital · Beijing, Beijing Municipality and 2 other locations · NCT07372729

• Mediterranean Diet With Optional Cycling and Rowing to Improve Blood Sugar in Women with Prediabetes

  This study tests whether a Mediterranean diet, with or without supervised cycling and rowing, helps women with prediabetes keep their blood sugar in a healthier range.

  Recruiting Marmara University · Beykoz, Istanbul · NCT07326891

• DAG Oil for Metabolic Risk in Prediabetes

  This study tests whether replacing usual cooking oil with diacylglycerol (DAG) oil for four weeks improves blood sugar control and lipid levels in adults with prediabetes.

  Recruiting The First Affiliated Hospital of Guangdong Pharmaceutical University · Guangzhou, Guangdong · NCT07289880

• Saffron (Crocus sativus) tepal water extract for lowering meal-time blood sugar in obesity and prediabetes

  This study tests whether drinking a cold water extract made from saffron tepals before a meal can lower blood sugar after eating in adults with obesity or prediabetes.

  Recruiting Early Phase 1 University of Primorska · Izola · NCT07261475

• Comparing diabetes medicines to slow or reverse artery plaque in people with coronary artery disease and prediabetes

  The study will test whether semaglutide or dapagliflozin works better than metformin at slowing or reversing coronary artery plaque in people with coronary artery disease and prediabetes over 24 months.

  Recruiting Phase 4 National Institute of Cardiology, Warsaw, Poland · Warsaw · NCT07254572

• Pecan Snacking and Blood Sugar in Prediabetes

  In people with prediabetes, this 16-week study tests whether replacing high-fat, high-sugar snacks with pecans improves blood sugar, heart health, and overall diet quality.

  Recruiting Penn State University · University Park, Pennsylvania · NCT07235358

• Mediterranean Diet With or Without Potatoes in Adults with Prediabetes

  This study tests whether a Mediterranean-style diet with one medium potato per day is as good as a potato-free Mediterranean diet for people with prediabetes over 12 weeks.

  Recruiting Penn State University · University Park, Pennsylvania · NCT07229781

• New T-UP: Engaging vulnerable students in diabetes prevention

  This project will try an online, student-tailored diabetes prevention program to help UCLA undergraduates with prediabetes or high diabetes risk lose weight.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07225218

• Dihydroberberine (DHB) to raise GLP-1 and help blood sugar, appetite, and mood in adults with prediabetes

  This will try daily Dihydroberberine (DHB) pills for six weeks in adults with prediabetes to see if DHB raises GLP-1 and improves blood sugar control, appetite, energy, and mood compared with a placebo.

  Recruiting Nanjing Nutrabuilding Bio-tech Co., Ltd. · Addison, Illinois · NCT07210684

• Eight-hour early versus late eating windows to improve blood sugar and cardiometabolic health in overweight adults

  We will try early versus late 8-hour time-restricted eating with moderate calorie reduction to see if it improves blood sugar and heart-related health in adults who are overweight with normal glucose, prediabetes, or non-insulin-treated type 2 diabetes.

  Recruiting German Institute of Human Nutrition · Nuthetal · NCT07171281

• Nextida GC-B for improving post-meal blood sugar in adults with normal blood sugar or prediabetes

  This trial will test whether taking Nextida GC-B for 90 days improves post-meal blood sugar in adults with normal blood sugar or prediabetes compared with a placebo.

  Recruiting Rousselot BVBA · London, Ontario · NCT07149064

• Continuous glucose monitoring with Diabetes Prevention Program coaching to prevent type 2 diabetes

  This project will try adding continuous glucose monitors to DPP coaching to help adults with prediabetes stick to healthy habits and lower their risk of developing type 2 diabetes.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT07140848

• Beetroot juice to boost blood vessels, insulin sensitivity, and exercise in prediabetes on vs. off metformin

  In people with prediabetes, this study tests whether short-term inorganic nitrate from beetroot juice can improve blood vessel health, insulin sensitivity, and exercise capacity, and compares those already taking metformin with those who are not.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07131384

• PortionSize Ed mobile program to support healthier eating after a recent stroke for people with prediabetes or type 2 diabetes

  See if a mobile app called PortionSize Ed helps adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean-style diet.

  Recruiting University of Hawaii · Honolulu, Hawaii · NCT07120334

• Pre-screening to identify adults who may be eligible for future metabolic and mental health opportunities.

  This prescreening will see if adults with metabolic conditions or mental health disorders qualify for upcoming clinical opportunities by collecting health history, basic tests, and a doctor interview.

  Recruiting Clindove Research LLC · Brooklyn, New York · NCT07106879

• Personalized lab results for older adults with prediabetes using machine‑learned risk labels

  This trial tests whether adding a machine‑learned “very low risk” label to EHR lab messages helps adults 65 and older understand their prediabetes risk and feel better about their health.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT06995378

• How different foods change blood sugar after a meal.

  This project will test whether adding things like fiber, vinegar, amino acids, protein, or exercise to a standard meal changes post-meal blood sugar in people with prediabetes, type 2 diabetes, and healthy adults.

  Recruiting Stanford University · Stanford, California · NCT06989164

• Exploring the benefits of Bottarga supplementation for prediabetes

  This study is testing if adding Greek Bottarga to the diet can help overweight people with prediabetes improve their metabolic health compared to a similar dairy product.

  Recruiting Cambridge Health Alliance · Sommerville, Massachusetts · NCT06988462

• Improving oral and systemic health in people with prediabetes using personalized hygiene advice

  This study is testing whether personalized oral hygiene advice from dental professionals or AI can help people with prediabetes improve their oral and overall health.

  Recruiting The University of Hong Kong · Hong Kong, Sai Ying Pun · NCT06980701

• How pancreatic (islet) GLP-1 affects blood sugar in prediabetes

  We will test whether blocking the GLP-1 receptor changes insulin and glucagon release and fasting glucose in people with prediabetes.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT06967558

• Hands-on nutrition demonstrations added to the Diabetes Prevention Program for people with prediabetes

  This project will test whether adding a 7-week series of healthy cooking and nutrition demos to the Diabetes Prevention Program helps adults at risk for prediabetes stay engaged and put healthy eating into daily life.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT06897982

• Combining exercise with intermittent fasting to improve eye dryness in pre-diabetic psoriasis patients

  This study is testing if combining exercise with intermittent fasting can help reduce eye dryness in people with psoriasis and prediabetes.

  Recruiting Cairo University · Giza, Dokki · NCT06893913

• Daily peanut consumption for improving health in prediabetes

  This study is testing whether eating peanut butter every day can help people with prediabetes improve their health, including blood sugar levels and brain function.

  Recruiting Georgia State University · Atlanta, Georgia · NCT06867198

• Effects of a Mediterranean Diet with Potatoes on Heart and Metabolic Health in Adults with Pre-Diabetes

  This study is testing if adding baked potatoes to a Mediterranean diet can help adults with pre-diabetes improve their heart and metabolic health.

  Recruiting University of Nevada, Las Vegas · Las Vegas, Nevada and 1 other locations · NCT06817252

• Increasing exercise and stopping evening snacks to improve metabolic health in youth with prediabetes

  This study is testing if getting more exercise and stopping evening snacks can help teenagers with prediabetes improve their health.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06782906

• Digital health coaching using wearable technology for chronic disease prevention

  This study is testing whether digital health coaching with wearable technology can help people at risk of chronic diseases like high blood pressure and diabetes make healthier lifestyle choices to prevent these conditions.

  Recruiting Alexandra Hospital · Singapore · NCT06752772

• Heart rate variability training to improve glucose metabolism in prediabetes

  This study is testing if breathing exercises that help regulate heart rate can improve blood sugar levels in people with prediabetes.

  Recruiting Johannes Gutenberg University Mainz · Mainz, Mainz and 1 other locations · NCT06739993

• Exercise effects on metabolism and blood-cell networks in people with prediabetes

  This 8-week exercise program will try to improve weight, lab measures, and blood-cell and metabolic biomarkers in overweight or obese adults with prediabetes.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT06633575

• Assessing how meal timing affects glucose tolerance in young people

  This study is testing if eating meals at the right times for their body clocks can help young people aged 17-23 manage their blood sugar better.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06507722

• Whole Food for Families: a family whole-foods diet program to prevent type 2 diabetes

  This pilot randomized program will test whether a 12-week, family-centered, non-calorie-restricted whole-foods diet for parents with prediabetes and their children lowers adult HbA1c and improves family diet quality.

  Recruiting Vanderbilt University · Nashville, Tennessee · NCT06482944

• Using SMS reminders to help people with prediabetes lose weight

  This study tests if sending text message reminders about exercise and healthy eating can help people with prediabetes lose weight and avoid getting type 2 diabetes.

  Recruiting Centre Hospitalier Universitaire de la Réunion · Saint-Louis, Réunion and 1 other locations · NCT06477900

• Multidisciplinary care program for lifestyle changes in prediabetes

  This study is testing a team-based program to help people with prediabetes make lifestyle changes, like eating better and exercising more, to see if it can prevent them from developing type 2 diabetes.

  Recruiting Clinica Especializada en el Manejo de la Diabetes en la Ciudad de Mexico · Mexico City, Iztapalapa · NCT06468553

• A program to prevent Type 2 Diabetes through diet and exercise

  This study is testing a program that helps people lower their chances of getting Type 2 Diabetes by teaching them about healthy eating and exercise.

  Recruiting University of British Columbia · Edmonton, Alberta and 11 other locations · NCT06440395

• Effects of glucagon on insulin secretion and glucose metabolism in people without diabetes

  This study is testing how glucagon affects insulin and blood sugar levels in people who have normal or slightly high fasting glucose to better understand how to manage blood sugar.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06424106

• Understanding insulin and glucagon interactions during fasting in prediabetes

  This study is testing how insulin and glucagon work together to control blood sugar levels during fasting in people with prediabetes.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06424015

• Survey to determine eligibility for cardiovascular and obesity clinical trials

  This study is trying to see if people with heart issues or obesity can join new clinical trials by having them fill out a survey and undergo some health checks.

  Recruiting Brooklyn Clinical Research · Brooklyn, New York · NCT06412536

• Walking in nature versus urban areas for adults with prediabetes

  This study tests whether walking in nature instead of city areas can help adults with prediabetes improve their health and reduce stress.

  Recruiting at 3 sites University of Minnesota · Lake Forest, Illinois and 2 other locations · NCT06365723

• Acupuncture to reduce weight and belly fat in people with prediabetes

  This trial will try acupuncture versus a sham procedure in adults with prediabetes and combined obesity to see if it helps them lose weight, shrink their waist, and improve blood sugar and cholesterol.

  Recruiting Guang'anmen Hospital of China Academy of Chinese Medical Sciences · Beijing · NCT06359418

• Program for preventing diabetes in rural communities

  This study is testing whether group video sessions or a self-directed approach to a diabetes prevention program can help people in rural areas lose weight and stay healthy.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06252038

• Kuwait Adult Diabetes Epidemiological Multidisciplinary Program

  This study looks at people in Kuwait to see how obesity and genetics affect the risk of developing prediabetes and diabetes, hoping to find better ways to prevent these conditions.

  Recruiting Dasman Diabetes Institute · Kuwait City · NCT06115876

• Comparing ketogenic and low-fat diets for diabetes management

  This study tests whether a ketogenic diet or a low-fat diet works better for managing blood sugar and overall health in people with type 2 diabetes or prediabetes.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT06115265

• Comparing two care strategies for preventing cardiovascular events in at-risk patients

  This study tests if a new care strategy based on a detailed look at coronary artery disease can better prevent heart problems in people at risk but without symptoms, compared to the usual approach.

  Recruiting at 122 sites Cleerly, Inc. · Chandler, Arizona and 124 other locations · NCT06112418

• Exploring biomarkers for prediabetes and diabetes using MALDI-TOF MS technology

  This study is trying to find new markers in blood and urine samples that can help doctors better diagnose prediabetes and diabetes in different groups of people, including pregnant women.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06097065

• SMART goals program for youth with prediabetes

  This study is testing if a special goal-setting program can help overweight kids with prediabetes lose weight and improve their health compared to regular care.

  Recruiting at 2 sites Northwell Health · New York, New York and 1 other locations · NCT06067451

• Using Metformin to Improve Live Birth Rates in Women with Prediabetes Undergoing IVF

  This study is testing if taking metformin before IVF can help women with prediabetes have a healthier chance of getting pregnant and having a baby.

  Recruiting Shandong University · Jinan, Shandong · NCT06064669

• Using SGLT2 inhibitors with lifestyle changes to prevent complications in prediabetes patients

  This study is testing if a diabetes medication combined with lifestyle changes can help people with prediabetes and early kidney problems avoid serious health issues.

  Recruiting at 9 sites Phase 4 University Hospital Tuebingen · Berlin and 8 other locations · NCT06054035

• Comparing lean pork and plant-based protein diets for prediabetic adults

  This study tests whether eating lean pork or plant-based protein helps adults with prediabetes manage their blood sugar and build muscle better.

  Recruiting University of Arkansas · Little Rock, Arkansas · NCT06025292

• Understanding how metabolism and inflammation affect diabetes in teens

  This study is trying to see how body weight, lifestyle, and diet affect inflammation and metabolism in teens to better understand diabetes risk.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06007404

• Education on sexual dysfunction for patients with schizophrenia and diabetes

  This study tests whether providing education about sexual dysfunction can help adults with schizophrenia and diabetes feel better about their sexual health while they are on antipsychotic medication.

  Recruiting Zealand University Hospital · Slagelse · NCT05951660

• Effects of Time-Restricted Eating on Cardiometabolic Health

  This study is testing if eating only during a 9-hour window each day can help people with obesity and prediabetes improve their heart and metabolic health over 12 weeks.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT05866406

• Nutrition therapy program for obesity and diabetes in low-income individuals

  This study tests a special meal replacement program to see if it helps low-income people with obesity and diabetes lose weight and manage their blood sugar better.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05799222

• Impact of Dinner Timing on Obesity and Prediabetes

  This study tests whether eating dinner earlier or later can help people with obesity and prediabetes improve their metabolism and health.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT05745441

• Improving diabetes management in hospitals with a decision support tool

  This study is testing a new electronic tool that helps doctors manage blood sugar levels in hospitalized patients with diabetes to see if it improves their care and reduces costs.

  Recruiting at 2 sites Milton S. Hershey Medical Center · Hershey, Pennsylvania and 1 other locations · NCT05447806

• Investigating how genetics affect response to oral semaglutide in prediabetes and obesity

  This study is testing how genetics affect how well people with prediabetes and obesity respond to a three-month treatment with oral semaglutide.

  Recruiting Medical University of Bialystok · Bialystok, Podlaskie Voivodeship · NCT05340868

• Diabetes prevention program tailored for African Americans

  This study is testing a diabetes prevention program designed specifically for African Americans to see if a culturally tailored approach helps them lose weight and attend the program better.

  Recruiting Phase 2 University of Missouri, Kansas City · Kansas City, Missouri and 1 other locations · NCT05301413

• Understanding how obesity affects insulin resistance through diet and molecular profiling

  This study is trying to see how different diets can affect insulin resistance in people with obesity by looking at changes in their body and blood over 12 weeks.

  Recruiting Stanford University · Stanford, California · NCT05165706

• Understanding how genetics affect GLP-1 response in Mexican-Americans with prediabetes

  This study is trying to see how genetics affect how well GLP-1 therapy works for Mexican-Americans with prediabetes, to help create better, personalized treatments.

  Recruiting Phase 4 The University of Texas Health Science Center, Houston · Brownsville, Texas · NCT05119179

• Addressing food insecurities in people living with HIV

  This study is testing a new program to see if it can help people living with HIV who struggle with food insecurity improve their health and manage diabetes better.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04943861

• Effects of Mirabegron on Beige Fat Activation in Prediabetic Patients

  This study is testing if the drug mirabegron can help people with prediabetes by activating a type of fat that may improve their blood sugar levels and overall metabolism.

  Recruiting Phase 2 University of Kentucky · Lexington, Kentucky · NCT04666636

• Registry of patients with diabetes and those at risk of developing it

  This study is creating a registry of people with diabetes, those at risk for it, and healthy individuals to see how their health data can help improve care recommendations.

  Recruiting Medical University of Bialystok · Bialystok, Podlaskie Voivodeship · NCT04657367

• Observational study on bariatric surgery outcomes

  This study looks at how bariatric surgery affects weight loss and related health issues like diabetes in patients over two years after their surgery.

  Recruiting Medical University of Bialystok · Bialystok, Podlaskie Voivodeship · NCT04634591

• Using intermittent fasting to enhance insulin secretion in diabetes

  This study is testing if intermittent fasting can help people with prediabetes and type 2 diabetes improve their insulin levels and overall health compared to a regular diet.

  Recruiting at 8 sites University Hospital Tuebingen · Berlin and 7 other locations · NCT04607096

• Observational study on mood and cognition in people with Type 2 Diabetes and prediabetes

  This study looks at how mood and thinking skills are affected in people with Type 2 diabetes or prediabetes to see what factors might play a role over 18 months.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT04455867

• Identifying blood markers for early pancreatic cancer

  This study is trying to find specific blood markers that can help detect early pancreatic cancer in people who are at higher risk.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT03568630

NIH-funded research (newest 40 of 43)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes

  This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11585476

• Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes

  This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11537840

• Support for Monitoring and Remote Tracking for Prediabetes

  Aimed at helping adults with prediabetes use continuous glucose monitors (CGMs) through training and support from community health workers to improve self-management and prevent progression to diabetes.

  NIH research University of Houston · Houston, United States · NIH-11451569

• Effects of different exercise intensities on blood vessels and metabolism in prediabetes and diabetes

  This project tests how moderate and high-intensity interval exercise affects blood vessel and fat tissue function in male and female rats with prediabetes or diabetes.

  NIH research University of the Pacific-Stockton · Stockton, United States · NIH-11420736

• ONWARD: Helping teens and young adults with prediabetes and type 2 diabetes get the resources they need

  A study tests easy, in-clinic and post-visit resource help for teens and young adults with type 2 diabetes to address social needs that affect their health.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11416347

• Walking in greenspace and built environments for adults with prediabetes

  This study tests whether walking in parks or green spaces, compared to built environments, improves blood sugar and stress measures in adults with prediabetes.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11386681

• Understanding how fasting glucose is controlled in people with and without prediabetes

  This NIH grant studies how insulin and glucagon work together to control fasting glucose in people with and without prediabetes.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11384413

• Zinc and blood sugar in people at risk for diabetes

  A study will look at how zinc levels and genes that control zinc in the body relate to blood sugar and prediabetes in adults.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11374956

• Alzheimer's and related dementia risk in people with prediabetes and type 2 diabetes

  This project looks at brain changes, memory, medications, and health measures in older adults with prediabetes or type 2 diabetes to find what leads to dementia.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11367296

• Comprehensive periodontal care to help prediabetes and gum health

  A new Mayo Clinic study will test whether comprehensive gum treatment can slow the worsening of blood sugar and gum disease in adults with prediabetes.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11366654

• Promoting diabetes screening to improve health outcomes

  A study tests different messaging and outreach methods to encourage adults aged 35-70 with overweight or obesity to get screened for type 2 diabetes and prediabetes.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11364689

• Midlife obesity and prediabetes as triggers for later cognitive decline linked to immune dysregulation

  This grant explores how midlife obesity and prediabetes may lead to memory and thinking problems later in life by influencing brain inflammation and immune pathways.

  NIH research Michigan State University · East Lansing, United States · NIH-11345668

• Smartphone and smartwatch screening for prediabetes and type 2 diabetes

  This project uses data from smartphones and smartwatches to spot early signs of prediabetes and type 2 diabetes in adults who have no symptoms.

  NIH research Duke University · Durham, United States · NIH-11332756

• How prediabetes and type 2 diabetes affect the eyes

  Using advanced eye scans and routine health tests to find early eye changes in adults with prediabetes or type 2 diabetes.

  NIH research University of Houston · Houston, United States · NIH-11322992

• Precision medicine for prediabetes: uncovering cardiometabolic subtypes to sharpen risk prediction

  A Johns Hopkins study will use patient data to find prediabetes subtypes based on cardiometabolic clues and see how these groups differ in progression to diabetes and heart/kidney risks.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11293532

• How midlife obesity and prediabetes affect brain health in older adults

  This study is looking at how being overweight and having prediabetes in middle age might affect thinking and memory as we get older, especially by exploring how inflammation in the brain could play a role, and it aims to find ways to help prevent or slow down cognitive decline for older adults.

  NIH research Michigan State University · East Lansing, United States · NIH-11176336

• Investigating cognitive impairment in older adults with prediabetes and type 2 diabetes

  This study is looking at how prediabetes and type 2 diabetes might impact thinking and memory in older adults, and it aims to find ways to help prevent these issues by understanding different health factors and habits.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11162996

• Walking in parks versus urban streets for adults with prediabetes

  This project compares short walks in parks versus walks in urban streets to help adults with prediabetes improve blood sugar control and reduce stress.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11145173

• Understanding nerve cell communication in obesity, prediabetes, and diabetes

  This project explores how nerve cells communicate and how this process is affected by conditions like obesity and diabetes, hoping to find new ways to treat nerve damage.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11118802

• Understanding Zinc and Genes in Prediabetes

  This research explores how zinc and your genes might work together to affect prediabetes.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11112485

• Fasting blood sugar control in people with and without prediabetes

  This project looks at how the hormones insulin and glucagon affect fasting blood sugar in adults with and without prediabetes.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11100011

• Using mobile technology to identify prediabetes and type 2 diabetes in adults

  This study is looking for adults to help test new smartphone and smartwatch tools that can track glucose levels and predict the risk of prediabetes and type 2 diabetes, making it easier for more people to get checked for these conditions.

  NIH research Duke University · Durham, United States · NIH-11093345

• Genes and GLP-1 treatment response in Mexican‑American adults with prediabetes

  This project checks if genetic differences change how Mexican‑American adults with prediabetes respond to GLP‑1 therapies.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11086079

• Investigating the risk of diabetes in women with HIV after pregnancy

  This study is looking at how having HIV might increase the chances of low-income Indian women developing prediabetes or type 2 diabetes after they've had gestational diabetes, and it aims to help find ways to prevent diabetes in these women by tracking their health and lifestyle over time.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11082212

• Understanding how diabetes affects eye health and vision loss

  This study is looking at how prediabetes and type 2 diabetes can affect your eye health, especially in causing vision problems, and it aims to find early signs of eye damage so that we can help prevent vision loss for people at risk.

  NIH research University of Houston · Houston, United States · NIH-11066500

• Investigating how prediabetes affects blood clotting in veterans

  This study is looking at how prediabetes might raise the chances of blood clots, which can lead to heart attacks and strokes, especially in veterans, and aims to find ways to help reduce these risks.

  NIH research Iowa City VA Medical Center · Iowa City, United States · NIH-11051607

• Improving physical function and quality of life in older adults with prediabetes through virtual resistance training

  This study is testing a fun online exercise program called Vivo for adults 55 and older, where you'll join small groups for personalized strength training sessions with certified trainers to help you stay strong, manage your blood sugar, and reduce the risk of falls, all while connecting with others for support and mot

  NIH research Impactiv, INC. · Atlanta, United States · NIH-10930148

• Investigating cognitive impairment in older adults with prediabetes and type 2 diabetes

  This study is looking at how prediabetes and type 2 diabetes might impact thinking and memory in older adults, especially those at risk for Alzheimer's and similar conditions, to find ways to help prevent or treat cognitive decline.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10924046

• Using glucose levels to identify early Alzheimer's risk in people with prediabetes.

  This study is looking at how changes in blood sugar levels might help spot early signs of Alzheimer's Disease in older adults who are at risk for Type 2 diabetes, using a special device that tracks glucose levels continuously to see how it relates to thinking and memory.

  NIH research University of Maryland Baltimore County · Baltimore, United States · NIH-10910153

• Using technology to treat sleep apnea in people with prediabetes

  This study is looking at how using technology to treat sleep apnea can help people with prediabetes feel better and stay healthier, by testing methods like CPAP therapy and lifestyle changes such as diet and exercise.

  NIH research University of Chicago · Chicago, United States · NIH-10886362

• Exploring how walking in green spaces affects adults with prediabetes

  This study is looking at how walking in parks and natural areas compared to city streets affects the health of adults with prediabetes, focusing on things like blood sugar levels, stress, and overall well-being, to help find better ways to prevent prediabetes from getting worse.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10870116

• Understanding how Schwann cells and nerves interact in obesity and diabetes

  This study is looking at how being overweight or having diabetes affects the nerves in your body, and it hopes to find out if changes in diet and exercise can help improve nerve health for people dealing with these conditions.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10854948

• Helping people with prediabetes lose weight in primary care

  This study is looking at a new way to help people with prediabetes lose weight by creating personalized plans that fit their needs and the abilities of their doctors, so they can better prevent type 2 diabetes in everyday healthcare settings.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10852997

• Creating a digital tool to help patients with prediabetes take charge of their health

  This study is creating a helpful online tool for people with prediabetes to boost their confidence and involvement in managing their health, making it easier for them to set personal goals and stay engaged in diabetes prevention programs.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10834219

• Improving muscle metabolism in prediabetes using SGLT2 inhibitors

  This study is looking at how a type of medication called SGLT2 inhibitors, which helps control blood sugar in people with type 2 diabetes, might also help improve muscle health and metabolism in those with prediabetes, so if you're at risk for diabetes, this research could be for you!

  NIH research Oregon State University · Corvallis, United States · NIH-10834043

• Understanding how diabetes affects color vision

  This study is looking at how diabetes and prediabetes affect color vision, especially in different parts of the eye, to help doctors understand and manage eye health better for people with these conditions.

  NIH research University of Houston · Houston, United States · NIH-10827984

• Effects of saccharin and acesulfame potassium on blood sugar levels in older adults with prediabetes

  This study is looking at how two artificial sweeteners, saccharin and acesulfame potassium, might affect blood sugar levels in older adults with prediabetes, to help understand if they could influence diabetes risk and guide better eating choices.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-10747446

• Using mirabegron and tadalafil to improve prediabetes treatment

  This study is looking at how well two medications, mirabegron and tadalafil, can help people with prediabetes improve their blood sugar levels and metabolism without needing to lose a lot of weight.

  NIH research University of Kentucky · Lexington, United States · NIH-10746813

• Using technology to treat sleep apnea in people with prediabetes

  This study is looking at how using technology to treat sleep apnea might help people with prediabetes improve their health, especially by seeing if CPAP therapy and lifestyle changes can lower their risk of developing diabetes and heart problems.

  NIH research University of Chicago · Chicago, United States · NIH-10677837

• Increasing physical activity in adults with prediabetes and diabetes through primary care interventions

  This study is looking to help adults with prediabetes and diabetes become more active by offering friendly support and advice during their doctor visits, and if you join, you'll get two years of phone coaching to help you move more and feel better!

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-10669156

Related topics

Quick answers

How many Prediabetes clinical trials are recruiting right now?

88, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (50 trials), China (8 trials), Germany (7 trials), Poland (4 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 4: 3, Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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