Examining how fat tissue expands during overeating

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the ability of subcutaneous adipose tissue to expand and remodel in response to short-term weight gain through controlled overfeeding. It aims to understand the mechanisms behind adipose tissue expandability and its implications for metabolic health, particularly in relation to conditions like obesity and metabolic syndrome. Participants will be randomized into control or overfeeding groups and monitored for changes in adipose tissue and cardio-metabolic health outcomes. The study will utilize deuterium-labeled water to track metabolic changes over an 8-week period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and pre-menopausal women
* 18-42 years of age
* BMI 23-35 kg/m2 (± 0.5 will be accepted)
* Are willing to drink deuterium-labeled water (2H2O) for 8 weeks
* Are willing to be randomized to either a CTL or 30% OF group
* For women, if not using pharmaceutical (hormonal) contraception (i.e. birth control pills, vaginal ring, injections, or implant), must agree to use either a double barrier method as a form of birth control to prevent pregnancy (i.e. male condom with spermicide, with or without cervical cap or diaphragm); use implants or intrauterine contraceptive devices; have a tubal ligation (surgically sterile); practice abstinence; or be in an established relationship with a vasectomized or same sex partner during the entire duration of the study
* Must be willing to adhere to all study procedures, including attendance at all study visits
* If enrolled, agree to maintain the same level of physical activity throughout the duration of the study
* Must be willing to have blood stored for future research

Exclusion Criteria:

* Unstable weight in the last 3 months (± \~5% weight change)
* Diagnosis of Type 1 or 2 diabetes or a fasting blood glucose \> 110 mg/dL
* Average screening blood pressure \> 140/90 mmHg
* Diagnosis of major organ disease (e.g. heart, kidney, lung, thyroid, liver disease) or abnormal liver enzymes that are, in the opinion of the MI, clinically significant and represent a problem for study inclusion.
* Self-reported positive test for human immunodeficiency virus, hepatitis B or hepatitis C
* Any current or previous eating disorders
* Chronic use of systemic glucocorticoids (steroids), systemic adrenergic-stimulating agents, beta-blockers, antipsychotic medications, thiazolidinediones and other medications that may cause clinically significant weight gain or loss)
* Chronic use of prescription weight loss medications or over the counter weight loss medications which, in the opinion of the MI, will impact the study
* Chronic use of anti-depressant medications for less than 3 months
* Chronic smokers or users of tobacco products who cannot abstain for the duration of the inpatient visits
* Previous bariatric or other surgeries for obesity
* Had cancer in the last 5 years (some skin cancers acceptable)
* Pregnancy, breastfeeding, or planned pregnancy for the upcoming 6 months
* Partial or full hysterectomy
* PCOS
* Diagnosed psychotic conditions.

Where it's running

• Pennington Biomedical Research Center
  Baton Rouge, Louisiana, United States Recruiting

Study contacts

• Principal investigator: Ursula White, Ph.D. — Pennington Biomedical Research Center
• Study coordinator: Ursula White, Ph.D.
• Email: ursula.white@pbrc.edu
• Phone: 225-763-2656

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Metabolic Health Trajectories in Overweight Chinese Adults

  This observational study follows overweight and obese Chinese adults to see how metabolic health changes over five years and whether people stay healthy, develop diabetes, or have complications.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT07584330

• Blood-count inflammation scores (SII and SIRI) to predict metabolic complications in adults with overweight or obesity

  This project will test whether two blood-count-based scores (SII and SIRI) can help predict metabolic complications and treatment response in adults with overweight or obesity.

  Recruiting University of Rijeka · Varaždin · NCT07431593

• App plus smart body fat scale program to help overweight people with schizophrenia or bipolar disorder lose weight

  See if using the Huawei Health app together with a smart body fat scale helps overweight people with schizophrenia or bipolar disorder lose weight and stay involved in their care.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT05866107

• Fulvic acid supplements for metabolic syndrome

  This study tests whether 50 mg or 100 mg of fulvic acid daily for 12 weeks can help people with metabolic syndrome or prediabetes.

  Recruiting Arizona State University · Phoenix, Arizona · NCT07927283

• Asprosin and miRNA Profiles in Young Women with Metabolic Syndrome

  This study tests whether certain blood biomarkers, including asprosin and six microRNAs, differ between young women with metabolic syndrome and healthy peers.

  Recruiting University of Applied Sciences in Nowy Targ · Nowy Targ, Lesser Poland Voivodeship · NCT07917364

• Nutrition support to improve dietary diversity in adults who are underweight or overweight/obese

  A community-based nutrition program will be tested in adults in Cambodia to see if it improves dietary diversity and if the program is acceptable and feasible to run.

  Recruiting National University of Singapore · Phnom Penh, Phnom Penh · NCT07836322

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.