Effects of Lactate on Nutrient Absorption in Pre-Diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how oral lactate administration influences nutrient absorption and fat utilization in individuals with pre-diabetes. The researchers hypothesize that lactate can improve post-meal fat metabolism by slowing gastric emptying and enhancing feelings of fullness. To measure these effects, a novel tracer method using a fluorine-labeled fatty acid analog combined with PET-CT imaging will be employed. The study aims to validate these effects in a Danish population, focusing on how lactate impacts fat partitioning during meals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 50+ years
* Written and oral consent
* HbA1c 39-47 mmol/L

Exclusion Criteria:

* Medicine with an impact on blood glucose and glucose metabolism.
* Newly started medicine (\<3 months prior to the inclusion time)
* Medicine changes (\<3 months prior to the inclusion time and planned changes during the trial)
* Affected screening blood sample as evaluated by PI
* Hba1c \> 47
* Allergy to paracetamol
* Doesn't speak or understand Danish
* Special diets

The eight healthy individuals will be included by the same criteria except for not having pre-diabetes

Where it's running

• Aarhus University Hospital
  Aarhus, Denmark Recruiting

Study contacts

• Principal investigator: Esben Søndergaard — Aarhus University, Steno Diabetes Center Aarhus
• Study coordinator: Natasa B Zubanovic, Medical Doctor
• Email: natasa.bz@clin.au.dk
• Phone: 004561698000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.