Effects of Lactate on Nutrient Absorption in Pre-Diabetes
Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?
NA · University of Aarhus · NCT06668714
This study is testing if taking lactate can help people with pre-diabetes absorb nutrients better and manage fat after meals.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | University of Aarhus (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Aarhus) |
| Trial ID | NCT06668714 on ClinicalTrials.gov |
What this trial studies
This study investigates how oral lactate administration influences nutrient absorption and fat utilization in individuals with pre-diabetes. The researchers hypothesize that lactate can improve post-meal fat metabolism by slowing gastric emptying and enhancing feelings of fullness. To measure these effects, a novel tracer method using a fluorine-labeled fatty acid analog combined with PET-CT imaging will be employed. The study aims to validate these effects in a Danish population, focusing on how lactate impacts fat partitioning during meals.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 50 and older with pre-diabetes, as indicated by specific HbA1c levels.
Not a fit: Patients with conditions affecting blood glucose metabolism or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved metabolic health and weight management for patients with pre-diabetes.
How similar studies have performed: While previous studies have shown promising results with lactate in other populations, this specific approach in pre-diabetes is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 50+ years * Written and oral consent * HbA1c 39-47 mmol/L Exclusion Criteria: * Medicine with an impact on blood glucose and glucose metabolism. * Newly started medicine (\<3 months prior to the inclusion time) * Medicine changes (\<3 months prior to the inclusion time and planned changes during the trial) * Affected screening blood sample as evaluated by PI * Hba1c \> 47 * Allergy to paracetamol * Doesn't speak or understand Danish * Special diets The eight healthy individuals will be included by the same criteria except for not having pre-diabetes
Where this trial is running
Aarhus
- Aarhus University Hospital — Aarhus, Denmark (RECRUITING)
Study contacts
- Principal investigator: Esben Søndergaard — Aarhus University, Steno Diabetes Center Aarhus
- Study coordinator: Natasa B Zubanovic, Medical Doctor
- Email: natasa.bz@clin.au.dk
- Phone: 004561698000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pre Diabetes, Metabolic Syndrome