Clinical trial Recruiting at 1 site Interventional Ages 15 to 20

Rise & Thrive: a community-engagement program to help youth manage stress and depressive symptoms

Official title: Rise & Thrive: Community-Engagement Intervention to Address Chronic Stress and Prevent Depression in Adolescents and Young Adults

Run by Ann & Robert H Lurie Children's Hospital of Chicago · NCT07554326 · Data updated 2026-11-12

A group-based program tests whether community engagement activities can help Black and/or Hispanic/Latine youth aged 15-20 see reductions in depressive symptoms.

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Quick facts

Study typeInterventional
Ages15 Years to 20 Years
SexAll
Enrollment300 (estimated)
SponsorAnn & Robert H Lurie Children's Hospital of Chicago
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedJune 9, 2026
Main results expectedDecember 1, 2028
Study endsDecember 29, 2029
Registry record updatedOctober 22, 2026
Trial IDNCT07554326 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are 15-20 year olds who identify as Black and/or Hispanic/Latine, speak English, and can attend in-person sessions in Chicago.

Probably not a fit

Youth who do not experience depressive symptoms or who cannot participate in in-person sessions may see limited benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase II randomized trial compares a Rise Together community engagement intervention to Adulting 101 life skills training in 300 youths aged 15-20 in Chicago. Participants are block-stratified by race/ethnicity and gender and then randomized to five half-day sessions of either community engagement or life skills training. The study measures depressive symptoms and psychological distress at baseline and multiple follow-ups up to 24 months, along with other health-related outcomes linked to chronic stress. The goal is to determine if a non-medication, behavioral intervention can reduce depressive symptoms and related distress in stressed youth from minority backgrounds. Recruitment focuses on in-person participation within the hospital’s catchment area and affiliated centers.

Why it matters

Potential benefit: If successful, participants and similar youth could experience fewer depressive symptoms and better coping with stress.

How similar studies have gone: Prior non-pharmacologic, youth-focused behavioral interventions have shown promise in reducing distress, though the specific community-engagement approach is relatively novel in this demographic.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. 15-20 years old
2. Identify as Black and/ or Hispanic/Latine
3. Speak English

Exclusion Criteria:

1. Younger than 15 years old, or older than 20 years old
2. Unable to attend the in-person sessions
3. Non-fluent English speaker
4. Do not identify as Black or Hispanic/Latine

Where it's running

  • Ann & Robert H. Lurie Children's Hospital of Chicago
    Chicago, Illinois, United States
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.