Understanding metabolic syndrome in pregnant women with HIV on specific treatments

Who could benefit from this research

What this research studies

This research investigates how certain HIV treatments, specifically Dolutegravir-based regimens, affect weight gain and metabolic health in pregnant women living with HIV. By conducting a prospective cohort study across multiple sites in the US and Nigeria, the research aims to identify cases of metabolic syndrome and understand the underlying mechanisms that contribute to these health issues during pregnancy. The study will utilize established criteria to assess metabolic syndrome risk among participants, providing valuable insights into the health challenges faced by this population.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Eke, Ahizechukwu C. — Johns Hopkins University
• Study coordinator: Eke, Ahizechukwu C.

Related research

Other NIH-funded projects on the same topics.

• Integrated biomarker study of metabolic syndrome in pregnant women with HIV on DTG-based ART

  Researchers will look for biological signs in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems happen and how these affect pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593952

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based ART

  This project looks at why some pregnant women living with HIV on a common DTG-based therapy gain weight or develop metabolic problems, by studying their proteins and metabolites across four sites in the US and Nigeria.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593951

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based therapy

  This project looks at markers in pregnant women living with HIV who are on a DTG-containing regimen to understand why some develop metabolic problems during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11572352

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on a DTG-based regimen

  Researchers will study blood and metabolite markers in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems may occur during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11325705

• Choline for fetal brain protection in pregnant women who drink heavily

  Giving choline to pregnant women who drink heavily may help protect the baby’s brain and improve early development.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11616489

• Mentor Moms+: a community-led plan to cut alcohol use and HIV risk during pregnancy in South Africa

  A community-based program adapts a trusted peer-led model to help pregnant and lactating people reduce alcohol use and HIV risk in South Africa.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11612340

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.