Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on a DTG-based regimen
Official title: Integrated proteomic and metabolomic biomarker profiling for understanding metabolic syndrome in pregnant women living with HIV on Tenofovir Disoproxil Fumarate/Lamivudine/Dolutegravir (TLD)
Funded at Johns Hopkins University · NIH-11325705 · Data updated 2026-11-12
Researchers will study blood and metabolite markers in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems may occur during pregnancy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 5, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $426,502 |
| NIH project number | 5DP1HD115433-03 |
| Project ID | NIH-11325705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals living with HIV who are on or starting a DTG-based ART regimen and receiving care at the participating sites.
✕Less likely to help
People not on a DTG-based regimen or not pregnant may not directly benefit from this study.
What this research studies
This project follows pregnant people living with HIV who are treated with a DTG-based regimen to see how their metabolic health changes. It will collect blood samples and profile proteins and metabolites across four sites in the US and Nigeria to identify patterns linked to weight gain and metabolic syndrome. The study uses a prospective cohort design to link treatment type with biomarker changes and pregnancy outcomes. Results could inform safer, more effective antiretroviral options for pregnant individuals living with HIV.
Why it matters
Potential benefit: If successful, the work could lead to better monitoring and management of metabolic health for pregnant people with HIV on DTG-based ART, potentially reducing pregnancy complications.
How similar studies have gone: Previous studies have linked DTG-based ART with weight gain and metabolic changes, but this project aims to clarify mechanisms through integrated biomarker profiling, which is a novel approach in this population.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Eke, Ahizechukwu C. — Johns Hopkins University
- Study coordinator: Eke, Ahizechukwu C.
Related research
Other NIH-funded projects on the same topics.
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Integrated biomarker study of metabolic syndrome in pregnant women with HIV on DTG-based ART
Researchers will look for biological signs in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems happen and how these affect pregnancy.
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Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based ART
This project looks at why some pregnant women living with HIV on a common DTG-based therapy gain weight or develop metabolic problems, by studying their proteins and metabolites across four sites in the US and Nigeria.
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Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based therapy
This project looks at markers in pregnant women living with HIV who are on a DTG-containing regimen to understand why some develop metabolic problems during pregnancy.
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Understanding metabolic syndrome in pregnant women with HIV on specific treatments
This study is looking at how a specific HIV treatment called Dolutegravir affects weight gain and overall health in pregnant women with HIV, to help understand any health challenges they might face during pregnancy.
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Choline for fetal brain protection in pregnant women who drink heavily
Giving choline to pregnant women who drink heavily may help protect the baby’s brain and improve early development.
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Mentor Moms+: a community-led plan to cut alcohol use and HIV risk during pregnancy in South Africa
A community-based program adapts a trusted peer-led model to help pregnant and lactating people reduce alcohol use and HIV risk in South Africa.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.