Immersive virtual reality training to improve thinking and memory in adults with metabolic syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind trial will enroll 84 adults aged 45–70 with metabolic syndrome and subjective cognitive complaints and assign them to either the Virtual-METS program or treatment-as-usual. The Virtual-METS program delivers group immersive virtual reality sessions combining cognitive training and physical exercise twice weekly for 12 weeks (24 sessions total). Primary outcomes are cognitive performance measured by a neuropsychological battery and eye-tracking tasks, with secondary outcomes of treatment adherence, daily functioning, and quality of life assessed at baseline, post-treatment, and six months. Ophthalmologic exams, carotid Doppler ultrasound, and panels of blood-based and gut-derived biomarkers will also be collected to explore physiological mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Demonstrated criteria for the MetS: central obesity (waist circumference ≥ 94 cm for men or ≥ 80 cm for women) and at least 2 of the criteria described as follow: Triglycerides ≥ 150 mg/dl or specific treatment of this lipid disorder; HDL-C \< 40 mg/dl (men) or \< 50 mg/dl (women) or specific treatment of this lipid disorder; Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg or previously diagnosed hypertension treatment; Basal glycemia ≥ 100 mg/dl or type 2 diabetes previously diagnosed).
* Age: between 45 and 70 years old.
* Subjective cognitive complaints: Subjective Cognitive Decline Questionnaire (≥ 7).
* Ability to fully understand and speak Spanish or Catalan.

Exclusion Criteria:

* Confirmed or suspicion of dementia (MMSE\<24).
* Diagnosis of severe psychiatric, neurological, developmental disorders, systemic pathologies, hematological, hormonal, nutritional pathology, and/or neoplasm that are known to cause cognitive deficits.
* Other severe comorbidities considered a probable bias for the study: a cardiac history of unstable angina, recent myocardial infarction within the last 3 months, congestive heart failure, significant heart valve dysfunction, or unstable hypertension; taking medications that could negatively affect cognitive function.
* Physical, motor, or sensory alterations that impede the neuropsychological examination or the rehabilitation program.

Where it's running

• Consorci Sanitari de Terrassa
  Terrassa, Spain Recruiting

Study contacts

• Study coordinator: Maite Garolera
• Email: mgarolera@cst.cat
• Phone: +34937310007

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.