Exercise effects on carotid artery function in young adults with metabolic syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study enrolls 48 young adults with and without metabolic syndrome who will complete four visits totaling about 5.5 hours. Investigators will measure internal carotid artery endothelial function using an inhaled CO2 gas stressor to acutely raise shear rate and record vascular responsiveness before and after a 30-minute bout of moderate-intensity cycling. The aims are to determine whether carotid endothelial dysfunction is present in young adults with metabolic syndrome, whether there are sex-specific differences, and whether a single exercise session acutely restores function. The protocol is observational and focuses on short-term vascular responses rather than long-term clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria (MetSyn cohort):

* Waist circumference greater than 102 cm (males) or 82 cm (females)
* Triglycerides over 150 mg/dL
* HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females)
* Blood pressure ≥130/85 mmHg
* Fasting plasma glucose over 110 mg/dL

Inclusion Criteria (Healthy cohort):

\- meet age criteria

Exclusion Criteria:

* Current smoker, defined as more than 5 cigarettes over past 30 days
* Current diagnosis or history of:

  * peripheral vascular disease
  * hepatic disease
  * renal disease
  * lung disease
  * gastrointestinal disorders/bleeding
  * hematologic disease
  * stroke
  * myocardial infarction
  * coronary heart disease
  * congestive heart failure
  * heart surgery
  * sleep apnea
  * autoimmune diseases
  * traumatic brain injury, concussion, stroke, or seizures
  * Asthma
  * Polycystic ovarian syndrome
* Type II diabetes
* Currently pregnant or breastfeeding
* Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives
* Hormonal contraceptive use, such as intrauterine device or hormonal implant use
* Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography

Exclusion Criteria (healthy controls only):

* BMI greater than 25 kg/m2
* Blood pressure over 125/80 mmHg
* Meeting any MetSyn criteria listed for MetSyn cohort

Where it's running

• University of Wisconsin
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: William Schrage, PhD — University of Wisconsin, Madison
• Study coordinator: Shawn Bolin, MS
• Email: sbolin@wisc.edu
• Phone: 608-263-6308

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.