Effects of Cetoleic Acid on Atherosclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of cetoleic acid-rich oil on atherosclerosis in individuals with metabolic syndrome. Participants will be randomly assigned to receive either the cetoleic acid oil or a control oil with lower cetoleic acid but similar levels of EPA and DHA. The study will measure changes in plasma levels of EPA and DHA, as well as various atherosclerotic markers, glucose, c-peptide, and triglycerides over a four-week period. The trial aims to determine if cetoleic acid can improve metabolic health and cardiovascular risk factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Triglycerides \> 1.7 mmol/L
* Waist measurement \> 80 cm (women) and \> 94 cm (men)

Exclusion Criteria:

* Chronic disease (liver/kidney/metabolism)
* Ongoing active cancer treatment
* Excessive alcohol consumption (\>40g/day)
* Pregnant/breastfeeding or planned pregnancy during the intervention
* High intake of fish (\>3 weekly meals)
* Level of free thyroxine (T4) and triiodothyronine (T3) outside reference ranges.
* Hypertension (≥ 160/ 100 mmHg)
* Total cholesterol \> 7.8 mmol/L
* Blood donation during the intervention period
* Difficulty following the protocol
* Smoking or sniffing
* Regular use (\> 1 day/week) of anti-inflammatory drugs
* Regular use of omega-3 supplements/cod liver oil
* Drug use other than stable use of statins, hypertension drugs (Ca antagonists, diuretics and beta blockers).
* Hormonal treatment excluding stable use of thyroxine and birth control pills/contraceptive rod

Where it's running

• Oslo University Hospital
  Oslo, Norway Recruiting

Study contacts

• Principal investigator: Kirsten B. Holven, PhD — Oslo University Hospital
• Study coordinator: Kirsten B. Holven, PhD
• Email: kirsten.holven@medisin.uio.no
• Phone: +4722851361

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.