Understanding gut health and metabolic syndrome in HIV-positive men
Gut microbiome effects on intestinal barrier function and metabolic syndrome in HIV positive men who have sex with men
This work explores how gut bacteria and intestinal health might contribute to metabolic syndrome in men living with HIV who have sex with men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11092260 on NIH RePORTER |
What this research studies
Many people living with HIV, especially men who have sex with men, experience metabolic syndrome, which increases their risk for heart problems. We know that gut bacteria and a healthy intestinal barrier are connected to metabolic syndrome in other groups, but this connection hasn't been fully understood in HIV-positive men. This project aims to uncover how changes in gut bacteria and a weakened intestinal barrier might lead to inflammation and metabolic syndrome in this specific population. By understanding these links, we hope to find new ways to improve health for these individuals.
Who could benefit from this research
Good fit: This research is relevant for HIV-positive men who have sex with men and are at risk for or experiencing metabolic syndrome.
Not a fit: Patients who do not have HIV or metabolic syndrome, or who are not men who have sex with men, may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing or managing metabolic syndrome in HIV-positive men by targeting gut health.
How similar studies have performed: While gut microbiome links to metabolic syndrome have been observed in other populations, this specific connection in HIV-positive men who have sex with men is not yet deeply understood.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Lozupone, Catherine — University of Colorado Denver
- Study coordinator: Lozupone, Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.