Understanding how glucose transport is regulated in metabolic syndrome
Vesicle Translocation and the Metabolic Syndrome
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11039963
This study looks at how insulin helps your body use sugar by focusing on a special protein that helps move sugar transporters to where they’re needed in your cells, and it aims to find out what goes wrong in people with insulin resistance, which could lead to better treatments for type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11039963 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which insulin regulates glucose uptake in muscle and fat cells, focusing on the role of a protein called TUG in the trafficking of GLUT4 glucose transporters. By examining how insulin triggers the movement of these transporters to the cell surface, the study aims to uncover the disruptions that lead to insulin resistance and metabolic syndrome. Patients may benefit from insights into how their bodies manage glucose, which could inform new treatment strategies for conditions like type 2 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with insulin resistance, metabolic syndrome, or type 2 diabetes.
Not a fit: Patients without metabolic disorders or those who do not have issues with glucose regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for managing blood sugar levels in patients with metabolic syndrome and type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding glucose transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOGAN, JONATHAN — YALE UNIVERSITY
- Study coordinator: BOGAN, JONATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus