Cranberry for gut and metabolic health in adults with overweight or obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, placebo-controlled crossover trial will enroll overweight and obese adults with metabolic risk factors and have each participant consume a cranberry beverage and a matched placebo for two 12-week periods separated by a 4-week washout. Primary outcomes include measures of glucose metabolism and insulin sensitivity, blood lipid concentrations, and analyses of gut microbiota composition and function, along with markers of intestinal integrity. Participants will be randomized to the order of interventions and both participants and study staff will be blinded to beverage assignment. Key exclusions include use of antidiabetic or lipid‑lowering medications, recent major surgery or bariatric procedures, regular probiotic or polyphenol supplement use, excessive alcohol intake, and cranberry aversion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* body mass index between 25 and 40 kg/m2
* at least one of the following criteria: fasting plasma insulin \>60 pmol/L, fasting glycemia between 5.5 and 6.9 mmol/L, glycated hemoglobin (HbA1c) level of 5.7- 6.4% and/or fasting triglyceride \>1.35 mmol/L.

Exclusion Criteria:

* to have aversion to cranberry products
* regularly drinking alcohol (\>2 glasses/day)
* having a significant change in body weight in the past 3 months (±5% of their body weight) due to bariatric surgery or other conditions
* taking medication which may affect the study outcomes (i.e. antidiabetic and/or cholesterol or lipid-lowering medications and/or glucocorticosteroid in supraphysiological doses and/or anti-obesity medications)
* taking regular probiotics and prebiotics (including fruit/berry polyphenol supplements) in the past 3 months
* having eating disorders
* had undergone major surgery 3 months prior to the study or if they had one planned
* if they had intestinal malabsorption, cirrhosis or chronic kidney disease
* being pregnant, planning a pregnancy, or breastfeeding.

Where it's running

• INAF, Université Laval
  Québec, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Julie Marois, M.Sc.
• Email: julie.marois@fsaa.ulaval.ca
• Phone: 1-418-656-5258

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.