Exploring genetic factors of obesity in young Chinese individuals
Study of Clinical Characteristics and Genetic Susceptibility in Chinese Obese Youngs
This study is trying to see how genetics might play a role in obesity among young people in China by comparing those who are obese with those who are not.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 8000 (estimated) |
| Ages | 14 Years to 30 Years |
| Sex | All |
| Sponsor | Shanghai Jiao Tong University School of Medicine Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT01084967 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic susceptibility and pathogenesis of obesity among young individuals in China. By enrolling obese patients and healthy lean controls, the study will utilize advanced techniques such as enzyme-linked immunosorbent assay and real-time fluorescence quantitative PCR to analyze genetic markers and copy number variations associated with obesity. The findings are expected to enhance understanding of the genetic contributions to obesity and metabolic syndrome, potentially guiding future treatment strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with a body mass index (BMI) of 30 kg/m2 or higher, predominantly from East China.
Not a fit: Patients with obesity caused by specific medical conditions such as Cushing syndrome or those with a history of major psychiatric illness may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for obesity and metabolic syndrome in affected populations.
How similar studies have performed: Previous studies have identified genetic factors associated with obesity, but this study's focus on copy number variation in a specific population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * body mass index (BMI)≥ 30kg/m2 * predominantly east China to minimize population stratification * willing and able to provide informed consent Exclusion Criteria: * pregnancy/lactation * Cushing syndrome * Hypothyroidism * obesity caused by pituitary and hypothalamic lesions * drug related obesity * history of major psychiatric illness
Where this trial is running
Shanghai, Shanghai Municipality
- Shanghai Jiao Tong University School of Medicine — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Principal investigator: Jie Hong, MD — Shanghai Jiao Tong University School of Medicine
- Study coordinator: Guang Ning, MD.PhD
- Email: guangning@medmail.com.cn
- Phone: 86-21-64370045
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.