Protecting tissue (bioprosthetic) heart valves in people with metabolic syndrome

Who could benefit from this research

What this research studies

I have a tissue (bioprosthetic) heart valve that can wear out faster if I have metabolic syndrome or diabetes. The team is testing a polymer called poly-2-methyl-2-oxazoline (POZ) applied to valve tissue to reduce protein sticking, sugar-related damage, oxidation, and calcium buildup. They will run lab tests using human serum, biochemical assays, and implants in Zucker diabetic fatty rats to see whether the coating lowers damage and calcification. If these experiments succeed, the approach could move toward use on surgical and transcatheter tissue valves for patients like me.

Why it matters

Where this research is happening

• Columbia University Health Sciences
  New York, United States Active

Researchers

• Principal investigator: Ferrari, Giovanni — Columbia University Health Sciences
• Study coordinator: Ferrari, Giovanni

Related research

Other NIH-funded projects on the same topics.

• Integrated biomarker study of metabolic syndrome in pregnant women with HIV on DTG-based ART

  Researchers will look for biological signs in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems happen and how these affect pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593952

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based ART

  This project looks at why some pregnant women living with HIV on a common DTG-based therapy gain weight or develop metabolic problems, by studying their proteins and metabolites across four sites in the US and Nigeria.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593951

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based therapy

  This project looks at markers in pregnant women living with HIV who are on a DTG-containing regimen to understand why some develop metabolic problems during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11572352

• Metabolic syndrome and brain support cells: how it may lead to Alzheimer’s disease

  A researcher is studying how midlife metabolic problems like diabetes and obesity may disrupt brain cells that support neurons, potentially leading to Alzheimer's disease and related dementia in later life.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11520494

• GLP-1 medicines to improve heart, kidney, and metabolic health for people with HIV and type 2 diabetes

  A real-world study will look at how GLP-1 receptor agonists affect heart and kidney health and lifetime costs for people living with HIV and type 2 diabetes.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11470780

• A new metabolic risk score to predict heart disease in Yup’ik Alaska Native adults

  A new, questions-free way to measure heart-disease risk in Yup’ik Alaska Native adults by combining everyday health clues with home-life factors.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11438029

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.