How metabolic syndrome affects the severity of brain infections caused by viruses.
Changes in Cellular Metabolism Associated with Metabolic Syndrome Increase the Severity of Neurotropic Viral Infections
['FUNDING_OTHER'] · UNIVERSITY OF KENTUCKY · NIH-11289064
This study is looking at how metabolic syndrome might make viral infections that affect the brain, like West Nile Virus, worse, and it’s for anyone interested in understanding why people with this condition may have tougher battles with these infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-11289064 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between metabolic syndrome (MetS) and the severity of viral infections that impact the brain, such as West Nile Virus. It focuses on understanding how metabolic imbalances in individuals with MetS can lead to worse outcomes during viral infections. By comparing brain metabolism in healthy mice and those with MetS, the study aims to identify specific metabolic changes that may increase viral activity and disease severity. This research could provide insights into why individuals with MetS experience more severe infections and longer hospital stays.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with metabolic syndrome, particularly those living in areas with higher incidences of viral infections.
Not a fit: Patients without metabolic syndrome or those not affected by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with metabolic syndrome who are at risk of severe viral infections.
How similar studies have performed: While the link between metabolic syndrome and viral infections is an emerging area, similar studies have shown that metabolic imbalances can influence disease outcomes, suggesting potential for success in this research.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PINTO, AMELIA KAHLER — UNIVERSITY OF KENTUCKY
- Study coordinator: PINTO, AMELIA KAHLER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease Outcome, disease severity