Condition

Cognitive Dysfunction clinical trials and research

• 70Clinical trials
• 50NIH research projects
• 1New in 30 days
• 22Countries

Newest Cognitive Dysfunction clinical trials

All recruiting trials (70)

• New flutemetamol F18 formulation to see if it works as well as current for brain amyloid imaging

  Researchers are testing a new flutemetamol F18 formulation (GE-287) to see if it identifies brain amyloid as accurately as the current formulation in people 50 and older who are undergoing amyloid PET scans for cognitive decline.

  Recruiting at 5 sites Phase 2 GE Healthcare · Aventura, Florida and 5 other locations · NCT07873463

• Longevity Metrics AI/ML Development Study

  Researchers are testing AI models that score health screening tests and predict outcomes like life expectancy for adults, using ongoing follow-up data.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07808619

• Immersive nature-based wellbeing program for older adults with cognitive impairment

  A nature-inspired immersive virtual reality program is being tested to see if it can improve well-being and daily function for older adults with mild to moderate cognitive impairment.

  Recruiting Consorci Sanitari de Terrassa · Terrassa, Barcelona · NCT07802392

• Hesperidin for better thinking in overweight older adults

  In adults aged 55–75 who are overweight, taking hesperidin or a placebo for 10 weeks will show whether the citrus flavonoid can improve thinking skills like memory, attention, and problem-solving.

  Recruiting University of Glasgow · Shanghai, Shanghai Municipality · NCT07750223

• Structured Receptive Music to Help with Care During Bathing for People with Dementia

  A structured daily music program used during hygiene care is being tested to see if it reduces refusals of care by residents with dementia in French nursing homes.

  Recruiting at 6 sites Lna Sante · Amiens and 11 other locations · NCT07730957

• Risk of delirium and cognitive problems after TUR-P in older adults

  This study tests whether certain perioperative factors can predict delirium and postoperative cognitive dysfunction in people aged 65 and older undergoing transurethral resection.

  Recruiting Muğla Sıtkı Koçman University · Muğla · NCT07719712

• Health Ahead: Comparing AI vs. Humans for Preventive Health Screening

  This study tests AI-assisted screening interpretation against human-only reads to see if automated screening can match or improve current practice for adults, especially in underserved areas.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07669168

• How environment and biology together predict health, aging, and death

  Researchers are following adults to see how living conditions and biology together relate to aging and life expectancy, by linking personal health data with environmental and social information over time.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07646782

• Vortioxetine for cognitive problems in ALK/ROS1-positive NSCLC treated with lorlatinib

  This observational study tests whether vortioxetine can help with cognitive and neurological side effects in adults with ALK/ROS1-positive NSCLC who are taking lorlatinib.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá · NCT07633626

• Donanemab in Early Cognitive Decline with Lewy Body Features (TRAILBLAZER-ALZ 7)

  This trial tests donanemab versus placebo to see if it can slow thinking and daily-function decline in people with early cognitive decline and Lewy body disease features.

  Recruiting at 47 sites Phase 2 Eli Lilly and Company · Chandler, Arizona and 71 other locations · NCT07589595

• 100-Year Human Aging and Longevity Tracking Program

  This project will follow adults over their lifetimes to see if repeated health tests can predict lifespan, causes of death, serious disease, and loss of function.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07563777

• Non-invasive brain stimulation plus computer-based memory training for mild cognitive impairment

  This trial will test whether a short course of non-invasive brain stimulation combined with one of two computer-based brain-training programs helps people aged 60–85 with mild cognitive impairment improve memory, thinking, mood, and daily function.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07526740

• Cognitive rehabilitation for ME/CFS brain fog

  Researchers are testing two cognitive rehabilitation approaches to see which helps adults with ME/CFS and brain fog better manage thinking and daily tasks.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07523113

• At-home ear vagus nerve stimulation plus computer brain training for thinking and mood

  This study will try at-home transcutaneous auricular vagus nerve stimulation combined with computerized cognitive training to see if it helps people aged 45-80 with self-reported cognitive changes improve thinking and mood.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07517237

• Developing and testing the Liver Cirrhosis Cognitive Decline Scale (LiCCoS)

  This project will test a short questionnaire called LiCCoS to see if it can spot thinking and everyday mental problems in adults with liver cirrhosis.

  Recruiting University of Malaya · Ambāla, Haryana · NCT07418008

• Median nerve stimulation to improve thinking after recent traumatic brain injury

  This trial will test whether noninvasive median nerve stimulation can help improve thinking, memory, and attention in adults who have cognitive problems soon after a traumatic brain injury.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07413562

• ALA-enriched nutrition to prevent cognitive decline in older adults with APOE4

  This study will test whether taking daily alpha-linolenic acid (ALA) supplements can slow cognitive decline and improve brain blood-vessel and barrier health in older adults with mild cognitive impairment who carry the APOE4 gene.

  Recruiting Phase 2 Rutgers, The State University of New Jersey · New Brunswick, New Jersey · NCT07392723

• Fatigue and thinking problems after allogeneic stem cell transplant (synapse damage or brain GVHD)

  This project uses PET scans and spinal fluid samples to try to find why people who had an allogeneic stem cell transplant have persistent fatigue and thinking problems.

  Recruiting Karolinska University Hospital · Stockholm · NCT07365696

• Eye movement parameters and cognitive function in older adults

  This study tests whether eye movements can help detect cognitive impairment in people aged 65 and older.

  Recruiting National Sun Yat-sen University · Kaohsiung City · NCT07358598

• Broccoli sprout extract to improve thinking and memory

  This will test whether taking broccoli sprout extract daily for 12 weeks improves thinking and memory in adults 55–85 with mild cognitive impairment.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT07334366

• Primary aldosteronism and thinking/memory problems

  This study will see if people aged 40 and older with primary aldosteronism develop memory and thinking problems over 1 to 5 years and which factors influence those changes.

  Recruiting at 2 sites Xinjiang Medical University · Chengdu, Sichuan and 1 other locations · NCT07304674

• Eye scan to detect Alzheimer’s related protein deposits in adults with memory issues

  A screening eye test is being tried in adults with memory problems to see if retinal changes can signal Alzheimer’s-related protein deposits.

  Recruiting at 2 sites Eli Lilly and Company · Abu Dhabi and 2 other locations · NCT07254234

• Gut-derived flavonoid compounds to support thinking and memory

  This trial will test whether a polyphenol supplement that boosts gut-produced flavonoid metabolites can help slow cognitive decline in people aged 50 and older who are at increased risk for Alzheimer's.

  Recruiting University of Ulster · Coleraine · NCT07226674

• Tracking frailty and thinking before and after pre-surgery chemotherapy for advanced ovarian and endometrial cancer

  This study will see if an automated frailty score and brief thinking tests change after 3–4 cycles of neoadjuvant (pre-surgery) chemotherapy in people over 55 with advanced ovarian or endometrial cancer.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT07220512

• Sexual problems in women with relapsing-remitting multiple sclerosis

  See if sexual dysfunction is common in women aged 25-50 with relapsing-remitting MS and whether it's linked to fatigue, mood, bladder symptoms, and cognitive problems.

  Recruiting Ege University · Izmir, Bornova · NCT07193823

• Video games versus ball-tossing to improve hand–eye coordination in older adults with mild cognitive impairment

  This project will test whether playing video games or doing ball-tossing exercises can improve hand–eye coordination in people aged 60 and older with mild cognitive impairment.

  Recruiting Foundation University Islamabad · Islamabad · NCT07182396

• Computerized brain-training for older adults with thinking or memory problems after viral infection

  This trial tests whether a six-week computerized brain-training program helps older adults who have lasting memory or thinking problems after COVID-19.

  Recruiting UConn Health · Farmington, Connecticut · NCT07171450

• AI-driven multimodal tool to identify early cognitive problems in people with type 2 diabetes

  This project will test whether an AI-based multimodal screening system can find early memory problems in people aged 40–75 with type 2 diabetes during a 3–5 year follow-up.

  Recruiting at 15 sites Tongji Hospital · Enshi, Hubei and 20 other locations · NCT07128186

• Immersive virtual reality cognitive rehabilitation for post-stroke cognitive impairment

  This pilot will try immersive virtual reality exercises with adults who have cognitive problems after a stroke to see if the approach is feasible, safe, and acceptable during outpatient rehabilitation.

  Recruiting University of Chile · Independencia, Santiago Metropolitan · NCT07125170

• 40 Hz Gamma Auditory Stimulation for Cognitive Decline in Older Adults

  This study tests whether a 40 Hz auditory stimulation device can help improve thinking skills in older adults with mild cognitive impairment or mild dementia.

  Recruiting Chang Gung Memorial Hospital · Taoyuan, Guishan · NCT07087951

• Daily Lab4P probiotic to improve thinking and metabolic health in overweight young adults with mild glucose regulation problems.

  This 12-week trial will test whether taking a daily Lab4P probiotic can improve memory, thinking speed, and blood sugar control in overweight 18–40-year-olds with mildly impaired glucose regulation.

  Recruiting Leeds Beckett University · Leeds, Greater Manchester · NCT07073781

• Cognitive training for insomnia with cognitive impairment

  This study tests if a new cognitive training program can help people with chronic insomnia and mild memory problems sleep better and improve their thinking skills.

  Recruiting Xuanwu Hospital, Beijing · Beijing · NCT06969066

• HOBSCOTCH-MS: Home-based telehealth cognitive coaching for people with multiple sclerosis

  This program will test whether a home-based telehealth cognitive coaching program (HOBSCOTCH-MS) can improve thinking, memory, and quality of life for people with MS and reduce caregiver burden.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06951919

• Investigating the link between pain sensitivity and cognitive issues in fibromyalgia patients

  This study is trying to see how pain sensitivity affects thinking problems in people with fibromyalgia.

  Recruiting Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · Istanbul, Uskudar · NCT06948903

• Cognitive Remediation Therapy for improving cognitive and emotional skills in schizophrenia

  This study tests if Cognitive Remediation Therapy can help people with schizophrenia improve their thinking and emotional skills over 12 weeks.

  Recruiting Beykoz University · Istanbul · NCT06936397

• Home-based self-management and cognitive training for brain tumor survivors

  This trial will try a home-based cognitive coaching program to see if it improves thinking and quality of life for adults who survived non-glioblastoma brain tumors, with optional caregiver participation.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06930846

• Nutrition-based interventions to prevent cognitive decline

  This study is testing if a 6-month nutrition program can help adults at higher risk for dementia keep their thinking skills sharp.

  Recruiting at 2 sites Instituto de Saude Publica da Universidade do Porto · Porto, Portugal and 1 other locations · NCT06853405

• Low-dose Esketamine for preventing delirium in elderly patients undergoing surgery

  This study is testing if low-dose Esketamine can help prevent confusion after surgery in older adults aged 65 to 90.

  Recruiting at 3 sites Nanfang Hospital, Southern Medical University · Fuzhou, Fujian and 5 other locations · NCT06817239

• Using a VR app to improve cognitive skills in patients with mild cognitive impairment

  This study is testing if a virtual reality app can help improve thinking and social skills in people with mild cognitive impairment compared to regular therapy.

  Recruiting IRCCS Centro Neurolesi Bonino Pulejo · Messina, Italy · NCT06793735

• Autologous fat-derived stem cell treatment for early Alzheimer's disease.

  This trial will test whether infusions of a person's own fat-derived stem cells can reduce brain inflammation and improve thinking in adults with early Alzheimer's disease or mild cognitive impairment.

  Recruiting Phase 1/2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06775964

• Using brain stimulation and digital training to improve cognitive function in older adults

  This study is testing whether a combination of brain stimulation and digital training can help improve thinking skills in older adults with Mild Cognitive Impairment and Alzheimer's Disease.

  Recruiting Universidade Federal do Rio de Janeiro · Rio de Janeiro, Rio de Janeiro · NCT06733714

• Group cognitive rehabilitation for Veterans with depression-related thinking problems

  This trial tests whether an 8-week group program that teaches compensatory thinking strategies with motivational and mindfulness supports can help Veterans treated for major depression who still have memory, attention, or other thinking problems.

  Recruiting Portland VA Medical Center · Portland, Oregon · NCT06728774

• Research on aging and cognitive impairment in China

  This study is trying to understand how health and thinking skills change as people get older in China, especially among the elderly, to help create better support and treatments for aging-related issues.

  Recruiting First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT06679296

• Early diagnosis and intervention for cognitive dysfunction in diabetes patients

  This study is trying to find early signs of thinking problems in people over 45 with Type 2 diabetes to help them get better care.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06650969

• Observing brain blood vessel health in a community

  This study looks at how blood vessel health in the brain is affected by conditions like high blood pressure and diabetes in adults aged 50-75 living in Beijing.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06579677

• Pilot test of the bWell‑D VR cognitive program for adults with major depression

  This pilot will test whether a VR cognitive assessment and an eight‑week VR cognitive training program (bWell‑D) are acceptable and doable for adults with major depressive disorder who report cognitive problems.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06546917

• Effects of polyphenols on cognitive decline in older adults

  This study is testing if a supplement made from polyphenols, which are found in Mediterranean foods, can help older adults at risk for Alzheimer's disease keep their brains healthy and slow down cognitive decline.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT06507254

• Digital cognitive intervention for high-risk dementia populations

  This study is testing a new digital program that combines education, exercise, art, and brain training to see if it can help people with early signs of memory problems and reduce their risk of developing dementia.

  Recruiting Fujian Provincial Hospital · Fuzhou, Fujian · NCT06442943

• Investigating fatigue and cognitive dysfunction in patients after stem cell transplantation

  This study is trying to see if there are specific signs in the blood and spinal fluid that can help identify fatigue and thinking problems in patients who have had stem cell transplants.

  Recruiting Karolinska Institutet · Stockholm · NCT06363396

• Computerized cognitive stimulation for older adults with varying cognitive reserve

  This study is testing a computer program that helps older adults improve their thinking skills, especially those who may be at risk of cognitive decline.

  Recruiting Universidad de Zaragoza · Zaragoza, Zaragoza · NCT06279325

• Exploring the impact of cognitive leisure activities on early Alzheimer's disease

  This study looks at how engaging in fun brain activities might help people with early signs of Alzheimer's disease think better and stay mentally active.

  Recruiting Fujian Provincial Hospital · Fuzhou, Fujian · NCT06215274

• Online cognitive exercises with supervision for breast cancer patients after chemotherapy

  This study is testing whether online brain exercises with help from a neuropsychologist can better reduce memory and thinking problems in breast cancer patients after chemotherapy compared to doing the exercises on their own.

  Recruiting at 16 sites Centre Francois Baclesse · Bordeaux and 24 other locations · NCT06027632

• High-intensity exercise program for older adults with HIV to improve vascular and cognitive health

  This study tests whether a 16-week high-intensity exercise program can help older adults with HIV improve their heart and brain health compared to a moderate exercise routine.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05965518

• Cognitively engaging walking exercise and brain stimulation for older adults

  This study is testing if combining brain stimulation with fun walking exercises can help older adults with mild to moderate cognitive decline improve their thinking and walking skills.

  Recruiting at 2 sites University of Florida · Gainesville, Florida and 1 other locations · NCT05830942

• Assessing cognitive and quality of life issues in advanced cancer survivors treated with immunotherapy

  This study is testing a new therapy to see if it can help advanced cancer survivors who have received immunotherapy improve their mental health and cognitive challenges.

  Recruiting at 2 sites Universitair Ziekenhuis Brussel · Brussels, Brussels Capital and 1 other locations · NCT05667857

• Exploring brain blood flow and function in stroke, depression, dementia, and delirium

  This study is trying to see how different imaging techniques can help us understand blood flow in the brain of people with stroke, depression, dementia, and delirium, as well as healthy individuals.

  Recruiting University of Leicester · Leicester, Leicestershire and 1 other locations · NCT05649800

• Identifying predictors for treatment response in major depression

  This study is trying to find out what factors can help predict how well different treatments will work for people with major depression.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05616559

• Internet-based therapy for insomnia and cognitive health

  This study is testing whether an online therapy for insomnia can help improve sleep and thinking skills in people with mild cognitive impairment.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT05565833

• Investigating cognitive function in psychosis patients and cannabis users

  This study is testing how taking a break from cannabis for 28 days affects thinking skills and brain activity in people with psychosis and those who use cannabis but don’t have mental health issues.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT05445180

• Observational study on Alzheimer's disease and cognitive health in older adults

  This study is looking for older adults with and without memory problems to help researchers learn more about Alzheimer's disease and improve ways to prevent and treat it.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05372172

• Assessing mobility and fall risks in older adults with mild cognitive impairment

  This study is trying to find out what factors can help predict falls in older adults with mild cognitive impairment so that better prevention strategies can be developed.

  Recruiting at 2 sites University Hospital, Lille · Lille and 1 other locations · NCT05273125

• Using a passive home sensor to find digital signs of brain energy changes from nicotinamide riboside

  This project will try a contact-free home sensor to see if it can detect activity, sleep, and breathing changes related to nicotinamide riboside in people with mild cognitive impairment or mild Alzheimer's.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT05245903

• Improving math skills in children with learning disabilities

  This study tests a new way to help children with learning disabilities improve their math skills by using different methods to see what works best for them.

  Recruiting Stanford University · Palo Alto, California · NCT05201534

• A program to reduce postoperative delirium in older surgical patients

  This study is testing a program to see if special education and care can help prevent confusion after surgery in older patients aged 60 and above.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05114876

• Examining brain changes in colorectal cancer patients undergoing chemotherapy

  This study is trying to see how chemotherapy affects thinking and memory in people with colorectal cancer.

  Recruiting Parkview Health · Fort Wayne, Indiana · NCT05014399

• Cognitive Function and Fatigue After Brain Abscess

  This study is testing how brain abscesses affect thinking skills and tiredness in people who have had this condition.

  Recruiting University of Oslo · Oslo · NCT04938362

• Cognitive training for improving mental health in forensic patients

  This study is testing if a special brain training program can help improve thinking skills and mental health for people in a secure facility.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT04610697

• Effects of Dexmedetomidine on cognitive recovery after cardiac surgery

  This study is testing if a medication called Dexmedetomidine can help people recover their thinking skills better after having heart surgery.

  Recruiting at 3 sites Phase 4 Sunnybrook Health Sciences Centre · Vancouver, British Columbia and 7 other locations · NCT04289142

• Improving cognitive skills for Veterans with brain injuries

  This study is testing two different training programs using online tools to see if they can help Veterans with brain injuries improve their thinking skills for work and school.

  Recruiting VA Office of Research and Development · Sacramento, California · NCT04109027

• Exploring cognitive impairment and eye health in elderly individuals

  This study looks at how brain and eye health are connected in older adults with small vessel disease to see if certain changes can predict memory problems in the future.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT03542734

NIH-funded research (newest 40 of 50)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• The WNK1/OSR1 protein pathway's role in brain insulin use and age-related memory loss

  This project will see if the WNK1/OSR1 protein pathway makes the aging brain use insulin and sugar less well and whether fixing that can help memory in Alzheimer’s-related conditions.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11479058

• HIV-related brain inflammation and the complement system explained

  A study using a human brain model to understand how HIV drives brain inflammation and may cause cognitive problems by changing the brain’s immune system.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11469932

• Subjective thinking challenges in adults with lupus as they age

  This grant aims to understand how lupus-related cognitive problems affect adults, especially older adults, and tests a real-time method to track daily fluctuations in those symptoms.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11442899

• Pain, Mood, and Thinking Problems in HIV- and AUD-risk Patients

  A long-running NIH grant explores how alcohol use, HIV, and negative feelings affect thinking and pain, with the goal of improving care for people living with HIV who struggle with alcohol-related problems.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11416382

• Thinking and brain changes in childhood lupus

  This project uses brain scans and cognitive tests to learn why children with lupus sometimes have trouble with thinking and school.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11415453

• Brain immune cells and cognitive trouble in lupus

  A study in lupus patients and mouse models looks at how brain macrophages may be linked to thinking problems.

  NIH research Northwestern University · Chicago, United States · NIH-11391085

• How anesthesia can affect memory and thinking after surgery

  This research looks at how common anesthetic drugs might lead to memory, attention, or thinking problems after surgery, especially in babies and older adults.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11374157

• Brain blood flow patterns linked to hypoglycemia and thinking problems in diabetes

  A study is testing a new brain-imaging technique to see how recurrent low blood sugar affects brain blood flow and thinking in adults with type 2 diabetes.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11364144

• Bioenergetic supplements for hard-to-treat depression and anxiety

  A grant test-beds the idea that nutrients like creatine and acetyl-L-carnitine could help people with treatment-resistant depression, anxiety, and cognitive problems.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11352678

• Postoperative cognitive function after major cancer surgery in older adults

  A study to understand how brain function changes after major cancer surgery in people 65 and older and what this means for recovery.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11337675

• Brain enkephalin peptides that affect alcohol-related thinking problems

  Looking at whether natural brain peptides called enkephalins influence thinking and relapse risk for people with alcohol use disorder.

  NIH research University of Texas at Austin · Austin, United States · NIH-11336892

• Leveraging brain resilience to reduce cognitive decline in aging

  A Johns Hopkins team is studying how aging changes key brain circuits and how boosting inhibitory signals could help protect memory in older adults at risk for Alzheimer’s disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11335809

• Postoperative cognitive problems and Alzheimer’s-related dementia: how surgery may affect the aging brain

  Aging patients undergoing surgery may experience brain changes after the operation that could relate to later memory problems and dementia, and this study seeks to understand the biology behind that link.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11307000

• Sleep rhythms and wakeful thinking: early schizophrenia and sound-based sleep help

  Researchers are testing whether improving sleep rhythms with gentle sounds can help cognition in people with early schizophrenia.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11300993

• How sepsis-related brain inflammation leads to lasting thinking and memory problems

  This research looks at how sepsis-caused brain inflammation can lead to long-lasting problems with memory, attention, and mood in older adults and people with Alzheimer-like brain changes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11297700

• How blood vessel changes cause memory problems after sepsis

  This project aims to understand why people who survive sepsis often have lasting memory and thinking problems and to find ways to stop that from happening.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11289469

• Activating cell-protection pathways in aging immune cells after pneumonia to reduce muscle weakness and thinking problems

  This grant looks at how aging immune cells in the brain and body respond after pneumonia, with the goal of preventing problems with thinking and muscle strength as people get older.

  NIH research Northwestern University · Chicago, United States · NIH-11265973

• How HIV plus opioid use may cause brain changes tied to memory problems

  This research tests whether abnormal Tau proteins (pTau) cause thinking and memory problems in people living with HIV who also use opioids.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11263737

• Using RNA changes to reduce sex-based thinking and memory problems

  This work looks at whether fixing a specific RNA edit can ease thinking, memory, and social problems that differ between males and females, with relevance to autism.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11251813

• Brain causes of thinking and mood problems in childhood lupus

  This project uses different brain scans and measures to find why children and teens with lupus have trouble with thinking, memory, or mood.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11173802

• Exploring supplements to treat depression and anxiety

  This study is looking at whether taking certain supplements, like creatine and acetyl-L carnitine, can help people with depression and anxiety who haven't found relief from regular medications, especially by improving their thinking and mood.

  NIH research University of Utah · Salt Lake City, United States · NIH-11171639

• How changes in brain circuits lead to memory and thinking problems in Alzheimer's

  Using advanced computer models, researchers map how changes in brain circuits lead to memory and thinking problems in people with Alzheimer's.

  NIH research Stanford University · Stanford, United States · NIH-11131097

• Understanding cognitive problems after traumatic brain injury

  This study is looking at how brain injuries can affect memory and thinking by using pigs to learn more about these changes, with the hope of finding new ways to help people recover their cognitive abilities after a traumatic brain injury.

  NIH research Philadelphia VA Medical Center · Philadelphia, United States · NIH-11088023

• Understanding Brain Changes from Low Blood Sugar in Type 2 Diabetes

  This research explores how repeated episodes of low blood sugar in people with Type 2 diabetes affect their brain and thinking abilities.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11083684

• Investigating how certain peptides affect cognitive issues caused by alcohol use

  This study is looking at how certain brain chemicals related to alcohol use might affect thinking and memory, with the goal of finding better ways to help people stick to their treatment and stay sober.

  NIH research University of Texas at Austin · Austin, United States · NIH-11080222

• Using memantine to protect children's cognitive function during brain radiation therapy

  This study is looking at whether giving memantine, a medication that helps protect the brain, can help kids aged 4-18 keep their thinking skills sharp while they receive radiation treatment for brain tumors.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11077359

• Investigating how tau protein affects brain function in people with HIV and opioid use disorder

  This study is looking at how a protein called tau might affect thinking and memory in people with HIV who also use opioids, to see if reducing tau could help improve their brain health and cognitive skills over time.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11067820

• Investigating sleep patterns and cognitive issues in early schizophrenia

  This study is looking at how sleep problems, like unusual sleep patterns, affect thinking skills in people with early-stage schizophrenia, and it will also test if using sound to improve sleep can help boost their cognitive abilities.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11057633

• How sepsis affects brain function and memory

  This study is looking at how surviving sepsis can affect your memory and learning over time, and it aims to find ways to help prevent or treat these issues for people who have gone through sepsis.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11042778

• Exploring how a specific protein affects thinking problems related to blood vessel issues.

  This study is looking at how a specific protein might affect thinking and memory problems in people with vascular dementia and possibly those who have had COVID-19, and it will also explore if combining exercise with a special treatment can help improve brain function for those dealing with these issues.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11040843

• Investigating how myeloid cells differ in Alzheimer's disease and HIV-related cognitive issues.

  This study is looking at how memory and thinking problems from Alzheimer's disease are different from those caused by HIV in older adults, and it hopes to find special markers in immune cells that can help doctors tell them apart better.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11034783

• How prenatal stress affects brain development and cognitive function differently in males and females

  This study looks at how stress during pregnancy affects brain development in babies, which might lead to different risks for learning and anxiety problems in boys and girls, using mouse models to explore these effects and find ways to help.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11030580

• Investigating how inflammation affects thinking in people with acute depression.

  This study is looking at how inflammation might affect thinking and memory in people who are feeling very depressed, and it will test whether blocking a specific inflammation signal can help improve their mental performance.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11021026

• Examining how myeloid cells differ in Alzheimer's disease and HIV-related cognitive issues

  This study is looking at how certain brain cells behave differently in people with Alzheimer's disease compared to those with cognitive issues related to HIV, and it's for anyone interested in understanding these conditions better and how they affect the brain.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11010072

• High-intensity exercise to improve brain and blood vessel health in older adults with HIV.

  This study is looking at how high-intensity exercise can help older adults with HIV who are having trouble with thinking and blood vessel health, and it aims to see if working out can make their minds and arteries feel better.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11001585

• Understanding cognitive issues in children with lupus

  This study is looking at how childhood-onset systemic lupus erythematosus (cSLE) affects kids' thinking and learning, using special brain imaging tools to understand what’s happening in their brains, so we can find better ways to help them.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10987200

• Investigating the link between blood vessel damage and cognitive decline in sickle cell disease

  This study is looking at how damage to blood vessels in the brain affects thinking and memory in adults with sickle cell disease, using mice to learn more about the problem and find better ways to help those who struggle with these issues.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10935975

• Exploring how brain immune cells affect thinking problems in lupus patients

  This study is looking at how certain immune cells in the brain might affect thinking and memory problems in people with lupus, and it aims to find out if understanding these cells can help improve cognitive function for patients.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10885942

• Investigating a hormone treatment for cognitive issues caused by sepsis in older adults

  This study is looking at how sepsis can affect thinking and memory in older adults and is testing a hormone called hCG to see if it can help protect the brain and improve cognitive health after a severe infection.

  NIH research University of Florida · Gainesville, United States · NIH-10869217

• Understanding cognitive dysfunction in fibromyalgia

  This study is looking into how fibromyalgia affects thinking and memory, using special brain scans to understand what's happening in the brain, so we can find better ways to help people with this condition feel better.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10861485

Related topics

Quick answers

How many Cognitive Dysfunction clinical trials are recruiting right now?

70, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (25 trials), China (12 trials), Canada (5 trials), Turkey (Türkiye) (4 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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