Short versus long intermittent hypoxic-hyperoxic training for people with type 2 diabetes, including older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center randomized trial in Moscow will randomize adults aged 50–74 with type 2 diabetes to a 3-day IHHT course, a 10-day IHHT course, or a control gas-breathing group. Participants undergo supervised intermittent hypoxic-hyperoxic breathing sessions while the control group breathes a normoxic gas mixture. The primary outcomes are fasting glucose and HbA1c measured before and after the intervention. Secondary outcomes include cardiovascular measures, quality of life, cognitive tests, and biological age markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 50-74 years inclusive
* Type 2 diabetes mellitus confirmed by medical documentation
* Stable therapy for diabetes and other chronic diseases for at least 4 weeks prior to enrollment
* Ability to comply with study protocol requirements
* Signed informed consent

Exclusion Criteria:

* Type 1 diabetes mellitus
* Acute diabetes complications within 6 months (diabetic ketoacidosis, hyperosmolar hyperglycemic state, lactic acidosis, hypoglycemic coma)
* Acute or active chronic infections
* Angina pectoris functional class III-IV
* Uncontrolled grade 3 arterial hypertension (SBP ≥180 and/or DBP ≥110 mmHg)
* Acute cerebrovascular accident, myocardial infarction, surgical interventions, clinically significant injuries within 6 months
* Internal carotid artery stenosis \>60% and/or symptomatic stenosis 50-99%
* Chronic obstructive pulmonary disease and bronchial asthma
* Exacerbation and decompensation of chronic diseases within 1 month ALT and/or AST levels \>2-3 times upper limit of normal
* Congenital heart and major vessel abnormalities
* Implanted cardiac pacemaker
* Cancer with remission \<5 years
* Mental illness, drug addiction, alcohol dependence
* Pregnancy
* Inability to participate throughout the study period

Where it's running

• National Medical Research Center for Therapy and Preventive Medicine
  Moscow, Russia Recruiting

Study contacts

• Principal investigator: Oksana M Drapkina, MD, Prof. — National Medical Research Center for Therapy and Preventive Medicine
• Study coordinator: Mikhail G Chashchin, PhD
• Email: dr.chaschin@gmail.com
• Phone: +79774331118

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.