Using sit-stand desks to improve health in sedentary workers
Stand Up for Your Health: A Randomized Study
This study is testing if using sit-stand desks can help people with prediabetes, obesity, and metabolic syndrome who have desk jobs improve their health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 198 (estimated) |
| Ages | 18 Years to 79 Years |
| Sex | All |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT05585190 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effects of sit-stand desks on health outcomes in individuals with prediabetes, obesity, and metabolic syndrome who have sedentary jobs. Participants will be provided with sit-stand desks at their workplace and monitored for changes in insulin resistance, vascular function, and triglyceride levels over a specified period. The study builds on previous findings that suggest significant health improvements can occur with reduced sitting time. By focusing on a population at high risk for diabetes, the study seeks to provide actionable interventions to mitigate health risks associated with sedentary behavior.
Who should consider this trial
Good fit: Ideal candidates are overweight or obese individuals with sedentary jobs who are at risk for diabetes.
Not a fit: Patients with established cardiovascular disease or other serious health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce the risk of developing type 2 diabetes and improve overall metabolic health in at-risk individuals.
How similar studies have performed: Previous studies have shown promising results with similar interventions, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
1. Overweight or obese (body mass index of 25 kg/m2 or higher)
2. Employees with "sedentary" jobs, defined as spending at least 75% of their (8 hours or more) workday sitting at a desk (at home or in an office)
3. Defined as "at-risk" for diabetes, defined as either:
1. Prediabetes (HbA1c of 5.7% to 6.4%) or a fasting glucose of 100 to 125 mg/dL
2. Having one or more additional risk factors: (beyond BMI\>25)
* Age 45 years or older
* Family history of diabetes mellitus in a first-degree relative
* Physical inactivity (no structured exercise activity)
* History of gestational diabetes, hypertension, or dyslipidemia
* African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, or Pacific Islander ethnicity
Exclusion Criteria:
1. Established cardiovascular disease (myocardial infarction, coronary stent, coronary artery bypass grafting, cardiac transplant, or angina)
2. Established congestive heart failure or cardiomyopathy
3. Established peripheral vascular disease
4. Established diabetes (HbA1c ≥ 6.5% or on diabetes medications or insulin)
5. Chronic musculoskeletal disorders involving the lower extremities, such as arthritis of the knees or hips, or regular use of ambulatory assist devices such as a walker or cane
6. Neuropathy of any etiology
7. Positional syncope or history of orthostasis
8. Less than 4 days/week at any single office (or work-from-home) location.
9. Current use of a standing desk for work
10. Tobacco use within the previous 12 months
11. Current illicit drug use or excessive alcohol use (defined as more than 14 drinks/week for women, more than 28 drinks/week for men)
12. Steroid use ≥21 days/year
13. Fasting triglyceride level ≥ 500 mg/dL
14. Thyroid disease
15. Uncontrolled or untreated hypertension(\>150/90 mm Hg)
16. Pregnant or lactating (or plans to become pregnant in the next 6 months)
17. LDL cholesterol ≥ 190mg/dL
18. Currently enrolled or plans to diet or join a weight loss program over the next 6 months.
19. Non-English speaker
Where this trial is running
Milwaukee, Wisconsin
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Study coordinator: Jacquelyn Kulinski, MD
- Email: jakulinski@mcw.edu
- Phone: 414-955-6896
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.