Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based therapy

Who could benefit from this research

What this research studies

Pregnant women living with HIV who are on dolutegravir-based ART will be followed in a multicenter cohort in the US and Nigeria to identify metabolic syndrome and its biomarkers using proteomic and metabolomic profiling. The study aims to link specific ART regimens to weight gain and metabolic changes, and to relate these findings to pregnancy outcomes. The approach combines blood-based biomarker analysis with clinical data to uncover mechanisms and potential targets for intervention. The research will leverage NIH infrastructure and involve collaboration across sites to ensure diverse participant representation.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Eke, Ahizechukwu C. — Johns Hopkins University
• Study coordinator: Eke, Ahizechukwu C.

Related research

Other NIH-funded projects on the same topics.

• Integrated biomarker study of metabolic syndrome in pregnant women with HIV on DTG-based ART

  Researchers will look for biological signs in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems happen and how these affect pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593952

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on DTG-based ART

  This project looks at why some pregnant women living with HIV on a common DTG-based therapy gain weight or develop metabolic problems, by studying their proteins and metabolites across four sites in the US and Nigeria.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11593951

• Biomarker profiling to understand metabolic syndrome in pregnant women with HIV on a DTG-based regimen

  Researchers will study blood and metabolite markers in pregnant women with HIV on a DTG-based regimen to understand why weight gain and metabolic problems may occur during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11325705

• Understanding metabolic syndrome in pregnant women with HIV on specific treatments

  This study is looking at how a specific HIV treatment called Dolutegravir affects weight gain and overall health in pregnant women with HIV, to help understand any health challenges they might face during pregnancy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11161556

• Choline for fetal brain protection in pregnant women who drink heavily

  Giving choline to pregnant women who drink heavily may help protect the baby’s brain and improve early development.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11616489

• Mentor Moms+: a community-led plan to cut alcohol use and HIV risk during pregnancy in South Africa

  A community-based program adapts a trusted peer-led model to help pregnant and lactating people reduce alcohol use and HIV risk in South Africa.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11612340

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.