Condition

Type 2 Diabetes Mellitus (T2DM) clinical trials and research

• 68Clinical trials
• 1New in 30 days
• 24Countries

Newest Type 2 Diabetes Mellitus (T2DM) clinical trials

All recruiting trials (68)

• Lifestyle change program to help type 2 diabetes go into remission in Pakistan

  This study tests whether a structured, plant-predominant lifestyle program can put adults with type 2 diabetes in Lahore, Pakistan into remission for the first six months.

  Recruiting at 2 sites Green International University · Lahore, Punjab Province and 1 other locations · NCT07912944

• Colchicine for preventing cardiovascular disease in adults with type 2 diabetes

  A 24-week study will test whether low-dose colchicine can help protect blood vessels in adults with type 2 diabetes who have not yet developed artery disease, compared with a placebo.

  Recruiting Phase 2 Tan Tock Seng Hospital · Singapore, Singapore · NCT07837934

• MWN105 injection in overweight or obese adults you may join

  This early-phase trial tests whether MWN105 is safe and tolerable in overweight or obese adults in China, using a placebo comparison.

  Recruiting Phase 1 Shanghai Minwei Biotechnology Co., Ltd · Kunming, Yunnan · NCT07803809

• MWN109 tablets in adults with type 2 diabetes mellitus

  A phase 2 trial tests MWN109 tablets versus placebo (and against active control semaglutide) to see if the medicine helps adults with type 2 diabetes lower their blood sugar.

  Recruiting Phase 2 Shanghai Minwei Biotechnology Co., Ltd · Beijing, Beijing Municipality · NCT07801820

• Brain-heart axis in adults with type 2 diabetes

  This study tests how brain activity and heart regulation relate to metabolic status in adults with type 2 diabetes to understand cognitive and functional health.

  Recruiting Hacettepe University · Tunceli · NCT07757308

• Digital dietary help for people on GLP-1 therapy to reach better blood sugar and weight

  This trial tests whether adding a digital dietary program (NutriSteppe) to usual care helps adults on GLP-1 medications see better blood sugar control and weight results.

  Recruiting Kazakh Academy of Nutrition · Almaty · NCT07728669

• Cilostazol and Aspirin to Prevent Heart and Brain Events in Type 2 Diabetes

  In people with type 2 diabetes and higher cardiovascular risk, researchers are testing whether taking cilostazol plus aspirin can help reduce major heart and brain events.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07719894

• Salivary biomarkers in people with periodontitis and type 2 diabetes

  This study tests whether saliva levels of apelin, chemerin, ghrelin, and lipocalin-2 differ across people with periodontitis, type 2 diabetes, both, or neither.

  Recruiting Necmettin Erbakan University · Konya, Konya · NCT07703345

• hUC-MSC-Exosomes for Type 2 Diabetes: Safety and Early Effect

  This study tests whether intravenous exosomes derived from human umbilical cord mesenchymal stem cells are safe and show early signs of benefit in adults with Type 2 diabetes.

  Recruiting Phase 1/2 Peking University First Hospital · Beijing · NCT07693036

• Pulse electric field ablation system for adults with type 2 diabetes and suboptimal drug control

  This study tests a pulse electric field ablation approach in adults with type 2 diabetes whose blood sugar remains above target despite medications.

  Recruiting Shanghai East Hospital · Shanghai · NCT07678866

• Enicepatide in people who are overweight or obese, with or without Type 2 diabetes

  This study tests whether enicepatide helps people who are overweight or have obesity, with or without Type 2 diabetes, lose weight when added to a reduced-calorie diet and more activity.

  Recruiting at 21 sites Phase 3 Hoffmann-La Roche · Zhengzhou, Henan and 20 other locations · NCT07670416

• VR-based cognitive training for adults with type 2 diabetes and mild cognitive impairment

  A 40-person randomized study in adults with type 2 diabetes and mild cognitive impairment tests whether a VR-based cognitive training program with diabetes self-management beats traditional paper-and-pencil cognitive training.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07650318

• Mixed-reality tests to measure functional mobility in adults with type 2 diabetes

  Researchers are testing whether mixed-reality assessments can reliably measure how well adults with type 2 diabetes move and walk.

  Recruiting Selcuk University · Konya, Selcuklu · NCT07649967

• Liver Inflammation Index test for MASH in adults with T2DM and MAFLD

  This study tests a Liver Inflammation Index to see if it can identify MASH in adults who have both type 2 diabetes and MAFLD.

  Recruiting at 22 sites The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Bengbu, Anhui and 21 other locations · NCT07632677

• Single-dose subcutaneous UBT38006 in healthy adult males

  This early study tests if a single dose of UBT38006 is safe and tolerated in healthy adult men and compares its blood levels and effects to insulin products.

  Recruiting Phase 1 The United Bio-Technology (Hengqin) Co., Ltd. · Hefei, Anhui · NCT07630233

• Dapagliflozin to slow coronary plaque progression in type 2 diabetes

  This trial tests whether adding dapagliflozin to standard care can slow or reverse coronary plaque buildup in adults with type 2 diabetes and stable coronary disease.

  Recruiting at 2 sites Phase 4 Chinese PLA General Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07614230

• Investigating microcirculation with non-invasive devices in adults with or at risk for CKD

  This study tests two non-invasive devices (HEMI and SPG-NINOX) to see how small blood vessels behave in adults with or at risk for chronic kidney disease, hypertension, or type 2 diabetes.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT07604922

• Short versus long intermittent hypoxic-hyperoxic training for people with type 2 diabetes, including older adults

  This study will see if short (3-day) or longer (10-day) sessions of intermittent low-oxygen/high-oxygen breathing improve blood sugar control in people aged 50–74 with type 2 diabetes.

  Recruiting National Medical Research Center for Therapy and Preventive Medicine · Moscow · NCT07574333

• How beta cells work in early-onset type 2 diabetes

  This project will test whether beta cell function and HbA1C change differently over one year in Vietnamese adults with early-onset versus typical-onset type 2 diabetes.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City, Cho Lon Ward · NCT07574138

• Detecting pancreatic dysfunction in adults with type 2 diabetes

  This project tests whether blood tests, a stool sample, and an ultrasound can identify pancreatogenic diabetes in adults with type 2 diabetes.

  Recruiting West Kazakhstan Marat Ospanov Medical University · Aktobe, Aktobe · NCT07512934

• Transit bipartition using a metallic anastomotic clip and circular fundocorporeal gastroplication

  This trial tries a new metallic anastomotic clip to create a second stomach-to-ileum pathway to help adults with type 2 diabetes and BMI 25–34.9 improve blood sugar control.

  Recruiting The Society of Bariatric and Metabolic Surgeons of Kazakhstan · Astana · NCT07495020

• ALN-4324 for insulin sensitivity in adults with type 2 diabetes

  This study will test whether a single dose of ALN-4324 improves whole-body insulin sensitivity in adults with type 2 diabetes who are on stable metformin therapy.

  Recruiting Phase 2 Alnylam Pharmaceuticals · Chula Vista, California · NCT07465224

• Three-stage CGM integration program for older adults with insulin-dependent diabetes

  A program with three CGM-focused training sessions is being tested to see if it helps older adults using insulin wear CGMs more and manage their glucose better compared with standard CGM training.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07463209

• ACI-19764: safety, how the body handles it, and immune effects in healthy adults

  This trial will test ACI-19764 in healthy adults to see if it is safe, how the body absorbs and clears it, and whether it changes specific blood immune markers.

  Recruiting Phase 1 AC Immune SA · Groningen · NCT07463196

• Comparing blood sugar swings with different diabetes pill combinations in type 2 diabetes

  This study will test whether different combinations of empagliflozin, metformin, linagliptin, or anagliptin reduce blood sugar swings in adults with type 2 diabetes who remain uncontrolled on metformin plus an SGLT2 inhibitor.

  Recruiting Phase 4 JW Pharmaceutical · Seoul · NCT07442006

• Goal-Directed Heart, Kidney, and Metabolic Care to Help Adults with Diabetic Kidney Disease

  This trial tests a structured, early CKM care plan alongside usual care to see if it is feasible and safe for adults with type 2 diabetes and diabetic kidney disease who are at high cardiovascular risk.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07434791

• Local steroid injection in carpal tunnel syndrome with diabetes vs without diabetes

  This study tests whether a corticosteroid and lidocaine injection helps people with carpal tunnel syndrome who also have type 2 diabetes as well as those without diabetes.

  Recruiting Haydarpasa Numune Training and Research Hospital · Istanbul, Istanbul · NCT07433257

• Real-Time Glucose Monitoring After Hospital Discharge in Insulin-Treated Type 2 Diabetes

  This study tests whether real-time continuous glucose monitoring helps people with insulin-treated type 2 diabetes manage blood sugar better after leaving the hospital compared with standard finger-prick glucose checks.

  Recruiting at 4 sites Shanghai 6th People's Hospital · Shanghai and 3 other locations · NCT07414277

• Multimodal exercise program for middle-aged and older adults with diabetic sarcopenia

  This program will try a 12-week multimodal exercise plan with supervised, home-based, and digital support to improve muscle function and metabolic health in people aged 45–85 who have type 2 diabetes and sarcopenia.

  Recruiting Chung Shan Medical University · Taichung, Taiwan · NCT07398495

• Quinoa to improve blood sugar control and lipids in early type 2 diabetes

  This trial will try a quinoa-based diet to see if it improves blood sugar levels, reduces glucose swings, and helps lipid and insulin measures in adults with early-stage type 2 diabetes.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT07329231

• Semaglutide versus calorie restriction for adults with type 2 diabetes

  This study will test whether 12 weeks of semaglutide injections or a reduced-calorie diet better improves blood sugar, weight, liver fat, and inflammation in adults newly diagnosed with type 2 diabetes.

  Recruiting Phase 4 Second Affiliated Hospital of Nanchang University · Jiangxi, Nanchang · NCT07272343

• Nutritional care for adults with type 2 or drug-induced diabetes who are malnourished or at risk

  This observational study will follow adults with type 2 or drug-induced diabetes who are malnourished or at risk to see if taking a diabetes-specific high-calorie, high-protein oral supplement with soluble fiber helps their nutrition, blood sugar, and quality of life.

  Recruiting at 12 sites Outcomes'10 · Santander, Cantabria and 11 other locations · NCT07252765

• Cognitive screening and multidomain care to slow memory and thinking decline in older adults with type 2 diabetes

  This study will test whether regular cognitive screening plus a two-year program of medication optimization, adjusted HbA1c targets, vascular risk management, lifestyle changes, and social support can slow cognitive decline in people aged 65 and older with type 2 diabetes.

  Recruiting at 3 sites Steno Diabetes Center Copenhagen · Copenhagen and 2 other locations · NCT07250789

• Psychological well-being, depression, and quality of life in adults with type 2 diabetes

  This project will see if psychological well-being and depressive symptoms are linked to health-related quality of life in adults with type 2 diabetes attending an outpatient clinic.

  Recruiting National Taiwan University Hospital · Taipei · NCT07241325

• Thai PainPREDICT for detecting neuropathic pain in people with diabetes

  This project will test a Thai-language PainPREDICT questionnaire and a companion mobile app to help identify neuropathic pain in adults with type 1 or type 2 diabetes.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07195045

• Continuous glucose monitoring versus finger‑stick checks in pregnancy with type 2 diabetes

  This trial tests whether wearing a continuous glucose monitor helps pregnant people with type 2 diabetes keep up with blood sugar checks more than traditional finger‑stick testing.

  Recruiting at 2 sites Thomas Jefferson University · Sewell, New Jersey and 1 other locations · NCT07184775

• Complete pulpotomy versus root canal for irreversible pulpitis in adults with Type 2 diabetes

  This will test whether complete pulpotomy or root canal treatment better preserves symptom-free, functional mature back teeth with irreversible pulpitis in adults who have Type 2 diabetes.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07163975

• Pre-screening to identify adults who may be eligible for future metabolic and mental health opportunities.

  This prescreening will see if adults with metabolic conditions or mental health disorders qualify for upcoming clinical opportunities by collecting health history, basic tests, and a doctor interview.

  Recruiting Clindove Research LLC · Brooklyn, New York · NCT07106879

• MKP10241 for food effects, safety, blood sugar control, and weight management in adults with and without type 2 diabetes.

  This study will test whether the experimental pill MKP10241 is safe, how food affects its levels in the body, and whether it helps control blood sugar and weight in obese adults with and without type 2 diabetes.

  Recruiting Phase 2 Mankind Pharma Limited · Bayswater, Victoria · NCT07098663

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• Tai Chi versus Modified-Otago exercises for pain, balance, and walking in diabetic peripheral neuropathy

  This trial will test whether Tai Chi or Modified-Otago exercises better reduce pain and improve balance and movement in people with diabetic peripheral neuropathy.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07078565

• Using a continuous glucose monitor to help young adults manage type 2 diabetes.

  This 30-day program gives young adults with type 2 diabetes a wearable continuous glucose monitor to try and see if real-time glucose data helps them notice patterns and manage their blood sugar and daily habits.

  Recruiting San Diego State University · San Diego, California · NCT07065721

• Tailored four-week online self-compassion program for adults with diabetes

  This four-week online self-compassion program is being tested to see if it reduces diabetes-related distress and improves wellbeing for adults with Type 1 or Type 2 diabetes.

  Recruiting Canterbury Christ Church University · Bangor, Wales and 1 other locations · NCT07051005

• Finerenone plus SGLT2 inhibitor for kidney and heart protection in type 2 diabetes

  This will test whether adding finerenone to SGLT2 inhibitor therapy reduces albuminuria and left ventricular damage in adults with type 2 diabetes and chronic kidney disease.

  Recruiting Phase 4 University of Aarhus · Aarhus N · NCT07026539

• Link between biological aging and type 2 diabetes risk in people with liver disease

  This study looks at how biological aging might affect the risk of developing type 2 diabetes in people with liver disease and those without it.

  Recruiting Ningbo No. 1 Hospital · Ningbo, Zhejiang · NCT06984510

• Impact of a vegetarian diet and exercise on type 2 diabetes management

  This study is testing whether a strict vegetarian diet and regular exercise can help people with type 2 diabetes manage their condition better.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06959043

• Henagliflozin safety and effects in Chinese adults with type 2 diabetes

  This project will see if henagliflozin is safe and helps lower blood sugar and improve weight, blood pressure, and muscle health in Chinese adults with type 2 diabetes treated in routine clinical care.

  Recruiting Second Affiliated Hospital of Guangxi Medical University · Beihai, Guangxi and 6 other locations · NCT06959030

• Precision nutrition to prevent diabetes and other metabolic diseases

  This trial will try personalized diets based on each person's metabolic 'metabotype' to see if they improve blood sugar control and prevent type 2 diabetes in adults with overweight or obesity.

  Recruiting at 2 sites Maastricht University Medical Center · Maastricht and 1 other locations · NCT06923644

• Flaxseed and quality of life in type 2 diabetes

  This study tests whether adding 30 g of ground flaxseed daily for 12 weeks to the diet improves blood chemistry and quality of life in adults with type 2 diabetes who aren’t on insulin.

  Recruiting Ondokuz Mayıs University · Samsun · NCT06911060

• IRIS-CKD Program 2: Improving screening and management for chronic kidney disease in people with type 2 diabetes

  This program will test whether a guided management program (plus education) helps doctors prescribe recommended CKD medicines for adults with type 2 diabetes and lab evidence of kidney disease.

  Recruiting at 7 sites Duke University · Birmingham, Alabama and 6 other locations · NCT06906640

• Improving kidney disease screening for adults with type 2 diabetes

  This program will test whether mailing home urine/blood test kits or giving a standard lab order helps adults with type 2 diabetes complete recommended kidney screening.

  Recruiting at 7 sites Duke University · Birmingham, Alabama and 6 other locations · NCT06906627

• Routine screening and support for emotional health in adults with type 2 diabetes

  This project will test whether routine screening for diabetes-related emotional distress plus brief clinic training helps adults with type 2 diabetes and A1C over 8% feel less distressed and manage their diabetes better.

  Recruiting University of Chicago · Chicago, Illinois · NCT06887049

• Time-restricted eating for people with type 2 diabetes and microalbuminuria

  This study tests whether following an 8–10 hour daily eating window can improve kidney health in adults with type 2 diabetes and microalbuminuria.

  Recruiting Phase 1 University of California, San Diego · La Jolla, California · NCT06884059

• Using continuous glucose monitors for diabetes management after hospital discharge

  This study is testing if using continuous glucose monitors can help adults with diabetes manage their blood sugar better after leaving the hospital.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06852950

• Culturally tailored ADA meals for Asian Indian and Filipino adults with type 2 diabetes

  This project will test whether culturally tailored, American Diabetes Association–compliant meals improve blood sugar control in Asian Indian and Filipino adults with type 2 diabetes by using a continuous glucose monitor.

  Recruiting Stanford University · Stanford, California · NCT06836479

• Improving diagnosis and treatment of diabetic retinopathy in type 2 diabetes

  This study is testing a new way to spot and treat diabetic eye disease in people with type 2 diabetes by using a mix of health data and advanced technology to improve care.

  Recruiting at 3 sites Shanghai General Hospital, China · Lanzhou and 2 other locations · NCT06821399

• Tropocells autologous platelet-rich fibrin for healing mild-to-moderate neuroischemic diabetic foot ulcers

  This will test whether Tropocells autologous platelet-rich fibrin (PRF) helps close mild-to-moderate neuroischemic diabetic foot ulcers in adults with type 1 or type 2 diabetes.

  Recruiting at 2 sites Phase 2 Estar Medical dba Medical Technologies, LTD · Corpus Christi, Texas and 1 other locations · NCT06810726

• Polyphenol metabolism patterns in people with type 2 diabetes

  This project will test whether people with type 2 diabetes process dietary polyphenols differently than age-matched people without diabetes by giving an oral polyphenol challenge and measuring blood, urine, gut transit, and microbial breakdown.

  Recruiting University Hospital, Ghent · Ghent, East Flanders and 1 other locations · NCT06810635

• Digital health coaching using wearable technology for chronic disease prevention

  This study is testing whether digital health coaching with wearable technology can help people at risk of chronic diseases like high blood pressure and diabetes make healthier lifestyle choices to prevent these conditions.

  Recruiting Alexandra Hospital · Singapore · NCT06752772

• Testing QX1206 in patients with Type 2 Diabetes and fatty liver disease

  This study is testing a new treatment called QX1206 to see if it can help adults with Type 2 diabetes and fatty liver disease manage their blood sugar and improve their health.

  Recruiting Phase 1 1Globe Health Institute · Toronto · NCT06694935

• Investigating body fat distribution and its impact on metabolic diseases in Japanese adults

  This study looks at how the way body fat is distributed affects the risk of metabolic and heart diseases in Japanese adults.

  Recruiting Osaka Metropolitan University · Sakai, Osaka · NCT06694012

• Evaluating HD-6277 for Type 2 Diabetes Control

  This study is testing a new medication called HD-6277 to see if it can help adults with Type 2 Diabetes better control their blood sugar when diet and exercise alone aren't enough.

  Recruiting Phase 2 Hyundai Pharm · Seoul · NCT06647550

• Using continuous glucose monitoring to manage type 2 diabetes during pregnancy

  This study is testing whether using continuous glucose monitoring can help pregnant people with type 2 diabetes manage their blood sugar better than traditional self-monitoring methods.

  Recruiting at 7 sites University of Alabama at Birmingham · Birmingham, Alabama and 6 other locations · NCT06628453

• Comparing two types of insulin for managing diabetes in pregnancy

  This study tests whether Glargine insulin works just as well as NPH insulin for managing diabetes in pregnant women who need insulin therapy.

  Recruiting Phase 3 Loyola University · Maywood, Illinois · NCT06619301

• Combining two diabetes medications for better blood sugar control

  This study is testing if using two diabetes medications together can help adults with type 2 diabetes better control their blood sugar and improve their overall health.

  Recruiting Phase 4 University Medical Centre Ljubljana · Ljubljana · NCT06613854

• Examining motor imagery and cognitive functions in people with Type 2 Diabetes

  This study tests how well people with Type 2 Diabetes can imagine movements and how that relates to their thinking skills and body awareness.

  Recruiting Kutahya Health Sciences University · Kütahya, Central · NCT06588894

• Addressing food insecurities in people living with HIV

  This study is testing a new program to see if it can help people living with HIV who struggle with food insecurity improve their health and manage diabetes better.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04943861

• Low-dose pioglitazone for treating liver disease in diabetes patients

  This study is testing if a low dose of pioglitazone can improve liver health in people with type 2 diabetes and a specific liver condition called NASH.

  Recruiting Phase 2 University of Florida · Gainesville, Florida · NCT04501406

Related topics

Quick answers

How many Type 2 Diabetes Mellitus (T2DM) clinical trials are recruiting right now?

68, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (16 trials), China (15 trials), Turkey (Türkiye) (6 trials), Kazakhstan (3 trials), South Korea (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 4: 6, Phase 1: 5, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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