Improving heart valve durability for patients with metabolic syndrome
Official title: Mitigation Strategies for Metabolic Syndrome-induced Bioprosthetic Heart Valve Degeneration
Funded at Columbia University Health Sciences · NIH-11051155 · Data updated 2026-11-12
This study is looking at how metabolic syndrome affects the lifespan of heart valves used in surgeries, and it aims to find ways to make these valves last longer for patients with this condition by testing a new material.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 10, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $687,963 |
| NIH project number | 5R01HL170573-02 |
| Project ID | NIH-11051155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with metabolic syndrome who require bioprosthetic heart valves for heart surgery.
✕Less likely to help
Patients without metabolic syndrome or those who do not require heart valve interventions may not benefit from this research.
What this research studies
This research investigates how metabolic syndrome affects the durability of bioprosthetic heart valves, which are commonly used in heart surgeries. It focuses on understanding the mechanisms that lead to structural valve degeneration in patients with metabolic syndrome and aims to develop a new approach using poly-2-methyl-2-oxazoline (POZ) to enhance the performance of these heart valves. By conducting experiments on both human samples and animal models, the research seeks to identify ways to reduce the negative effects of metabolic syndrome on heart valve implants, potentially leading to longer-lasting solutions for patients. The ultimate goal is to improve outcomes for patients undergoing surgical or transcatheter heart valve interventions.
Why it matters
Potential benefit: If successful, this research could lead to more durable heart valves for patients with metabolic syndrome, improving their quality of life and surgical outcomes.
How similar studies have gone: Previous research has shown promising results in enhancing the durability of bioprosthetic materials through innovative functionalization techniques, indicating potential success for this approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Ferrari, Giovanni — Columbia University Health Sciences
- Study coordinator: Ferrari, Giovanni
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.