Electrical stimulation plus isometric exercise to improve blood flow in resistant high blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Fifty participants aged 50–60 with resistant hypertension will be randomly assigned to medication plus a combined TENS and isometric exercise program or to medication plus a conventional physical therapy program. The TENS protocol targets cervicothoracic sympathetic outflow (C7–T4) with electrodes over the upper thoracic paraspinal muscles while isometric and other exercise components follow a prescribed physical therapy regimen. Primary outcomes are peripheral hemodynamic measures including systolic and diastolic blood pressure, mean arterial pressure, pulse pressure, and heart rate variability, measured before and after the intervention. The trial excludes secondary hypertension, recent major cardiovascular events, and severe musculoskeletal or neurologic disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 50 and 60 years. Both sexes were included Patients had been diagnosed with hypertension for at least 5 years.

Patients had resistant hypertension according to (Whelton et al 2018), defined as:

* Systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg despite the use of three or more antihypertensive medications of different classes, including a diuretic,
* or controlled blood pressure (\<140/90 mmHg) while on four or more antihypertensive medications.

Body Mass Index (BMI) 25: 34.9 kg/m²

Increased waist circumference, defined as:

* Greater than 102 cm for males.
* Greater than 88 cm for females.

Exclusion Criteria:

* Secondary hypertension due to identifiable causes (e.g., renal artery stenosis, primary aldosteronism, pheochromocytoma).
* History of major cardiovascular events in the last 6 months (e.g., myocardial infarction, stroke, or heart failure exacerbation).
* Severe musculoskeletal or neurological disorders that impair the ability to perform isometric exercise safely (e.g., recent joint replacement, severe osteoarthritis, stroke with residual motor deficit).
* Contraindications to the use of Transcutaneous Electrical Nerve Stimulation (TENS):

Implanted electronic devices: pacemakers, cardioverter defibrillators. Uncontrolled arrhythmias. Sever skin condition: open wounds, rashes, burns, eczema. Peripheral neuropathy or sensory loss.

-Known cognitive impairment or psychiatric conditions that would limit the ability to follow instructions or provide informed consent.

Where it's running

• Out Clinics of Port Said Hospitals
  Port Said, Port Said Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Mohamed Mohamed Morgan, Bachelor of Physical Therapy
• Email: m.morgan@cu.edu.eg
• Phone: 201026099152

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.