Genetic factors linked to heart, kidney, and diabetes risks in NHPI people

Who could benefit from this research

What this research studies

This project studies how genetic differences influence the intertwined risks of heart disease, kidney disease, and type 2 diabetes in Native Hawaiians and Pacific Islanders. Researchers are using long-read whole-genome sequencing to build a distinctive NHPI genetic reference and identify population-specific variants that affect CKM risk. The work involves analyzing phenotypic and multi-omics data from over 800 participants in the UPIS to connect genetics with disease pathways. The ultimate goal is to better predict risk and tailor prevention and treatment for NHPI communities, addressing a major health disparity.

Why it matters

Where this research is happening

• Utah State Higher Education System--University of Utah
  Salt Lake City, United States Active

Researchers

• Principal investigator: Pezzolesi, Marcus Guy — Utah State Higher Education System--University of Utah
• Study coordinator: Pezzolesi, Marcus Guy

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.